Impact of meningioma surgery on use of antiepileptic, antidepressant, and sedative drugs: A Swedish nationwide matched cohort study

Cancer Medicine - Tập 10 Số 9 - Trang 2967-2977 - 2021
Erik Thurin1, Isabelle Rydén1, Thomas Skoglund2,1, Anja Smits1, Sasha Gulati3,4, Göran Hesselager5, Jiří Bártek6,7,8, Roger Henriksson9, Øyvind Salvesen10, Asgeir Store Jakola2,3,1
1Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden
2Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden
3Department of Neurosurgery, St.Olavs University Hospital HF, Trondheim, Norway
4Institute of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
5Department of Neurosurgery, Uppsala University Hospital, Uppsala, Sweden
6Department of Clinical Neuroscience and Department of Medicine, Karolinska Institutet, Stockholm, Sweden
7Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden
8Department of Neurosurgery, Rigshospitalet, Copenhagen, Denmark
9Department of Radiation Sciences & Oncology University of Umeå Umea Sweden
10Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway

Tóm tắt

AbstractBackgroundMeningioma is the most common primary intracranial tumor and surgery is the main treatment modality. As death from lack of tumor control is rare, other outcome measures like anxiety, depression and post‐operative epilepsy are becoming increasingly relevant. In this nationwide registry‐based study we aimed to describe the use of antiepileptic drugs (AED), antidepressants and sedatives before and after surgical treatment of an intracranial meningioma compared to a control population, and to provide predictors for continued use of each drug‐group two years after surgery.MethodsAll adult patients with histopathologically verified intracranial meningiomas were identified in the Swedish Brain Tumor Registry and their data were linked to relevant national registries after assigning five matched controls to each patient. We analyzed the prescription patterns of antiepileptic drugs (AED), antidepressants and sedative drugs in the two years before and the two years following surgery.ResultsFor the 2070 patients and 10312 controls identified the use of AED, antidepressants and sedatives was comparable two years before surgery. AED use at time of surgery was higher for patients than for controls (22.2% vs. 1.9%, p < 0.01), as was antidepressant use (12.9% vs. 9.4%, p < 0.01). Both AED and antidepressant use remained elevated after surgery, with patients having a higher AED use (19.7% vs. 2.3%, p < 0.01) and antidepressant use (14.8% vs. 10.6%, p < 0.01) at 2 years post‐surgery. Use of sedatives peaked for patients at the time of surgery (14.4% vs. 6.1%, p < 0.01) and remained elevated at two years after surgery with 9.9% versus 6.6% (p < 0.01). For all the studied drugs, previous drug use was the strongest predictor for use 2 years after surgery.ConclusionThis nationwide study shows that increased use of AED, antidepressants and sedatives in patients with meningioma started perioperatively, and remained elevated two years following surgery.

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Tài liệu tham khảo

10.1093/neuonc/noy131

10.1016/j.wneu.2015.01.022

10.1016/S1470-2045(16)30321-7

10.3171/2011.3.JNS101748

10.1007/s11060-012-0947-8

10.3171/2016.1.JNS151842

10.1093/neuonc/nos013

10.1007/s00701-019-03799-3

10.1093/neuonc/nov303

10.1007/s00701-017-3434-3

10.1007/s11060-018-2941-2

10.1097/00000658-193501000-00016

10.1007/s00701-012-1511-1

10.1016/S0920-1211(99)00066-2

Musluman AM, 2012, Unilateral frontal interhemispheric transfalcial approaches for the removal of olfactory groove meninjiomas, Turk Neurosurg, 22, 174

10.3171/jns.1984.60.1.0052

10.3171/2015.4.JNS142742

10.1093/neuros/nyx001

10.18632/oncotarget.15743

10.1007/s00520-012-1675-5

10.2340/16501977-1795

10.1093/neuonc/noy129.008

10.1016/j.genhosppsych.2008.09.006

10.1093/nop/npz066

10.1007/s00401-007-0243-4

10.1097/00005650-199801000-00004

10.1097/01.mlr.0000182534.19832.83

10.1371/journal.pone.0202575

10.36740/WLek202003126

10.1093/neuonc/nox237.001

10.1016/j.jocn.2017.05.020

10.1111/ane.12711

10.1007/s11096-016-0371-9

10.1159/000338081

Uzun S, 2010, Side effects of treatment with benzodiazepines, Psychiatria Danubina, 22, 90

10.2165/00023210-200317110-00004

10.1016/j.sleep.2004.03.007

10.1097/j.pain.0000000000000414

10.1093/fampra/cmh608

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Cancer Medicine

Tập 10 Số 9

2967-2977

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