Zhen Zhai1,2, Fang Zhang3, Yi Zheng1,2, Linghui Zhou1,2, Tian Tian1,2, Shuai Lin2, Yujiao Deng2, Peng Xu1,2, Qian Hao2, Na Li2, Pengtao Yang2, Hongtao Li4, Zhijun Dai1,2
1Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
2Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
3The Second Department of Oncology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefacture, Enshi, China
4Department of Breast Head and Neck Surgery, The 3rd Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Tumor Hospital), Urumqi, China
Tóm tắt
AbstractIntroductionIt remains unclear whether marital status could affect the breast cancer‐caused special survival (BCSS) of patients with breast cancer. Therefore, we sought to explore the influence of demographic and pathological factors on prognosis of patients with breast cancer.Materials and methodsWe selected patients meeting the eligibility criteria from the Surveillance, Epidemiology, and End Results (SEER) cancer registry program. We assessed the effect of marital status on overall survival (OS) and BCSS using Kaplan‐Meier curve and multivariate Cox proportional hazards regression.ResultsCompared with divorced/separated/widowed (DSW) patients, the married (AHR 0.7483, 95% CI: 0.729‐0.7682, P < 0.001) and single patients had better BCSS (AHR 0.9096, 95% CI: 0.8796‐0.9406, P < 0.001). Married patients kept better prognosis among all age subgroups, while the better BCSS of single patients occurred only in groups older than 35 years. As for race and hormone receptor status (HRs), the better BCSS of single patients was only observed in white race (AHR 0.881, 95% CI: 0.8457‐0.9177, P < 0.001) and patients with ER+/PR + status (AHR 0.8844, 95% CI: 0.8393‐0.932, P < 0.001).ConclusionOur findings demonstrated that married and single patients with breast cancer had better prognosis than their DSW counterparts. Age, race, and HRs could affect the correlation between marital status and BCSS.
