Cancer Epidemiology Biomarkers and Prevention

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Lysophospholipids Are Potential Biomarkers of Ovarian Cancer
Cancer Epidemiology Biomarkers and Prevention - Tập 13 Số 7 - Trang 1185-1191 - 2004
Rebecca Sutphen, Yan Xu, George D. Wilbanks, James V. Fiorica, Edward C. Grendys, James P. LaPolla, Hector Arango, Mitchell Hoffman, Martin A Martino, Katie Wakeley, David Ray Griffin, Rafael W. Blanco, Alan Cantor, Yijin Xiao, Jeffrey P. Krischer
Abstract Objective: To determine whether lysophosphatidic acid (LPA) and other lysophospholipids (LPL) are useful markers for diagnosis and/or prognosis of ovarian cancer in a controlled setting. Method: Plasma samples were collected from ovarian cancer patients and healthy control women in Hillsborough and Pinellas counties, Florida, and processed a...... hiện toàn bộ
Lead Exposure, Polymorphisms in Genes Related to Oxidative Stress, and Risk of Adult Brain Tumors
Cancer Epidemiology Biomarkers and Prevention - Tập 18 Số 6 - Trang 1841-1848 - 2009
Parveen Bhatti, Patricia A. Stewart, Amy Hutchinson, Nathaniel Rothman, Martha S. Linet, Peter D. Inskip, Preetha Rajaraman
Abstract There is some evidence that oxidative stress plays a role in lead-induced toxicity. Mechanisms for dealing with oxidative stress may be of particular relevance in the brain given the high rate of oxygen metabolism. Using a hospital-based case-control study, we investigated the role of oxidative stress in the potential carcinogenicity of lead...... hiện toàn bộ
Coffee, Tea, Caffeine Intake, and Risk of Adult Glioma in Three Prospective Cohort Studies
Cancer Epidemiology Biomarkers and Prevention - Tập 19 Số 1 - Trang 39-47 - 2010
Crystal N. Holick, Scott Smith, Edward L. Giovannucci, Dominique S. Michaud
Abstract Current data suggest that caffeinated beverages may be associated with lower risk of glioma. Caffeine has different effects on the brain, some of which could play a role in brain carcinogenesis, and coffee has been consistently associated with reduced risk of liver cancer, thus suggesting a potential anticarcinogenic effect. A total of 335 i...... hiện toàn bộ
Body Size, Mammographic Density, and Breast Cancer Risk
Cancer Epidemiology Biomarkers and Prevention - Tập 15 Số 11 - Trang 2086-2092 - 2006
Norman F. Boyd, Lisa Martin, Limei Sun, Helen Guo, Anna M. Chiarelli, Greg Hislop, Martin J. Yaffe, Salomon Minkin
AbstractBackground: Greater weight and body mass index (BMI) are negatively correlated with mammographic density, a strong risk factor for breast cancer, and are associated with an increased risk of breast cancer in postmenopausal women, but with a reduced risk in premenopausal women. We have examined the associations of body size and mammographic density on breast...... hiện toàn bộ
Cardiovascular Risk Factors in Adult Survivors of Pediatric Cancer—A Report from the Childhood Cancer Survivor Study
Cancer Epidemiology Biomarkers and Prevention - Tập 19 Số 1 - Trang 170-181 - 2010
Lillian R. Meacham, Eric J. Chow, Kirsten K. Ness, Kala Y. Kamdar, Yan Chen, Yutaka Yasui, Kevin C. Oeffinger, Charles A. Sklar, Leslie L. Robison, Ann C. Mertens
Abstract Background: Childhood cancer survivors are at higher risk of morbidity and mortality from cardiovascular disease compared with the general population. Methods: Eight thousand five hundred ninety-nine survivors (52% male) and 2,936 siblings (46% male) from the Childhood Cancer Survivor Study, a retrospectively ...... hiện toàn bộ
Enterolignan-Producing Phenotypes Are Associated with Increased Gut Microbial Diversity and Altered Composition in Premenopausal Women in the United States
Cancer Epidemiology Biomarkers and Prevention - Tập 24 Số 3 - Trang 546-554 - 2015
Meredith A. J. Hullar, Samuel M. Lancaster, Fei Li, Elizabeth Tseng, Karlyn D. Beer, Charlotte Atkinson, Kristiina Wähälä, Wade K. Copeland, Timothy W. Randolph, Katherine M. Newton, Johanna W. Lampe
Abstract Background: Lignans in plant foods are metabolized by gut bacteria to the enterolignans, enterodiol (END) and enterolactone (ENL). Enterolignans have biologic activities important to the prevention of cancer and chronic diseases. We examined the composition of the gut microbial community (GMC) as a contributor to human enterolignan exposure....... hiện toàn bộ
Glutathione Transferases and Glutathionylated Hemoglobin in Workers Exposed to Low Doses of 1,3-Butadiene
Cancer Epidemiology Biomarkers and Prevention - Tập 17 Số 11 - Trang 3004-3012 - 2008
Alessandra Primavera, Silvia Fustinoni, Antonino Biroccio, Sabrina Ballerini, Andrea Urbani, Sergio Bernardini, Giorgio Federici, Enrico Capucci, Maurizio Manno, Mario Lo Bello
Abstract We evaluated glutathione transferase (GST) activities and the levels of glutathionylated hemoglobin in the RBC of 42 workers exposed to 1,3-butadiene in a petrochemical plant, using 43 workers not exposed to 1,3-butadiene and 82 foresters as internal and external controls, respectively. Median 1,3-butadiene exposure levels were 1.5, 0.4, and...... hiện toàn bộ
Matrix Metalloproteinase-2Polymorphisms and Breast Cancer Susceptibility
Cancer Epidemiology Biomarkers and Prevention - Tập 18 Số 6 - Trang 1770-1776 - 2009
Alicia Beeghly‐Fadiel, Wei Lu, Jirong Long, Xiao‐Ou Shu, Ying Zheng, Qiuyin Cai, Yu‐Tang Gao, Wei Zheng
AbstractMatrix metalloproteinase-2 (MMP-2) is a well-known mediator of cancer metastasis but is also thought to be involved in several aspects of cancer development, including cell growth and inflammation. We comprehensively characterized genetic variation across the MMP-2 gene and evaluated associations with breast cancer risk using a two-phase (phase 1 and phase ...... hiện toàn bộ
Common Genetic Variation and Breast Cancer Risk—Past, Present, and Future
Cancer Epidemiology Biomarkers and Prevention - Tập 27 Số 4 - Trang 380-394 - 2018
Jenna Lilyquist, Kathryn J. Ruddy, Celine M. Vachon, Fergus J. Couch
Abstract Breast cancer is the most common cancer among women in the United States, with up to 30% of those diagnosed displaying a family history of breast cancer. To date, 18% of the familial risk of breast cancer can be explained by SNPs. This review summarizes the discovery of risk-associated SNPs using candidate gene and genome-wide association st...... hiện toàn bộ
Radon and Lung Cancer in the American Cancer Society Cohort
Cancer Epidemiology Biomarkers and Prevention - Tập 20 Số 3 - Trang 438-448 - 2011
Michelle C. Turner, Daniel Krewski, Yue Chen, C. Arden Pope, Susan M. Gapstur, Michael J. Thun
Abstract Background: Case–control studies conducted in North America, Europe, and Asia provided evidence of increased lung cancer risk due to radon in homes. Here, the association between residential radon and lung cancer mortality was examined in a large-scale cohort study. Methods: Nearly 1.2 million Cancer Preventio...... hiện toàn bộ
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