Cardiovascular Risk Factors in Adult Survivors of Pediatric Cancer—A Report from the Childhood Cancer Survivor Study

Cancer Epidemiology Biomarkers and Prevention - Tập 19 Số 1 - Trang 170-181 - 2010
Lillian R. Meacham1, Eric J. Chow1, Kirsten K. Ness1, Kala Y. Kamdar1, Yan Chen1, Yutaka Yasui1, Kevin C. Oeffinger1, Charles A. Sklar1, Leslie L. Robison1, Ann C. Mertens1
1Authors' Affiliations: 1Aflac Cancer Center, Emory University, Atlanta, Georgia; 2Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington; 3St. Jude Children's Research Hospital, Memphis, Tennessee; 4Baylor College of Medicine, Houston, Texas; 5Department of Public Health Sciences, School of Public Health, University of Alberta, Alberta, Canada; and 6Memorial Sloan-Kettering Cancer Center, New York, New York

Tóm tắt

Abstract Background: Childhood cancer survivors are at higher risk of morbidity and mortality from cardiovascular disease compared with the general population. Methods: Eight thousand five hundred ninety-nine survivors (52% male) and 2,936 siblings (46% male) from the Childhood Cancer Survivor Study, a retrospectively ascertained, prospectively followed study of persons who survived 5 years after childhood cancer diagnosed from 1970 to 1986, were evaluated for body mass index of ≥30 kg/m2 based on self-reported heights and weights and self-reported use of medications for hypertension, dyslipidemia, and impaired glucose metabolism. The presence of three or more of the above constituted Cardiovascular Risk Factor Cluster (CVRFC), a surrogate for Metabolic Syndrome. Results: Survivors were more likely than siblings to take medications for hypertension [odds ratio (OR), 1.9; 95% confidence interval (95% CI), 1.6-2.2], dyslipidemia (OR, 1.6; 95% CI, 1.3-2.0) or diabetes (OR, 1.7; 95% CI, 1.2-2.3). Among these young adults (mean age of 32 years for survivors and 33 years for siblings), survivors were not more likely than siblings to be obese or have CVRFC. In a multivariable logistic regression analysis, factors associated with having CVRFC included older age at interview [≥40 versus <30 years of age (OR, 8.2; 95% CI, 3.5-19.9)], exposure to total body irradiation (OR, 5.5; 95% CI, 1.5-15.8) or radiation to the chest and abdomen (OR, 2.3; 95% CI, 1.2-2.4), and physical inactivity (OR, 1.7; 95% CI, 1.1-2.6). Conclusions: Among adult survivors of pediatric cancer, older attained age, exposure to total body irradiation or abdominal plus chest radiation, and a sedentary life-style are associated with CVRFC. Cancer Epidemiol Biomarkers Prev; 19(1); 170–81

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Cancer Epidemiology Biomarkers and Prevention

Tập 19 Số 1

170-181

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