Cancer Discovery
SCOPUS (2011-2023)SCIE-ISI
2159-8274
2159-8290
Mỹ
Cơ quản chủ quản: American Association for Cancer Research Inc. , AMER ASSOC CANCER RESEARCH
Lĩnh vực:
Oncology
Các bài báo tiêu biểu
Cổng thông tin cBio Genomics về ung thư: Nền tảng mở cho khám phá dữ liệu genomics ung thư đa chiều Dịch bởi AI Tóm tắt
Cổng thông tin cBio Genomics về ung thư (http://cbioportal.org... ... hiện toàn bộ
Tập 2 Số 5 - Trang 401-404 - 2012
#Genomics ung thư #cổng thông tin cBio #dữ liệu đa chiều #nghiên cứu ung thư #bộ dữ liệu genomics #phân tử và thuộc tính lâm sàng
Hallmarks of Cancer: New DimensionsAbstract
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have emerged as potent... ... hiện toàn bộ
Tập 12 Số 1 - Trang 31-46 - 2022
Fundamental Mechanisms of Immune Checkpoint Blockade TherapyAbstract Immune checkpoint blockade is able to induce durable responses across multiple types of cancer, which has enabled the oncology community to begin to envision potentially curative therapeutic approaches. However, the remarkable responses to immunotherapies are currently limited to a minority of patients and indications, highlighting the need for more effecti... ... hiện toàn bộ
Tập 8 Số 9 - Trang 1069-1086 - 2018
Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to ChemotherapyAbstract
Immune-regulated pathways influence multiple aspects of cancer development. In this article we demonstrate that both macrophage abundance and T-cell abundance in breast cancer represent prognostic indicators for recurrence-free and overall survival. We provide evidence that response to chemotherapy is in part regulated by these leukocytes; c... ... hiện toàn bộ
Tập 1 Số 1 - Trang 54-67 - 2011
Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer ResearchAbstract
Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passages. These models have been shown to be predictive of cli... ... hiện toàn bộ
Tập 4 Số 9 - Trang 998-1013 - 2014
AACR Project GENIE: Powering Precision Medicine through an International ConsortiumAbstract
The AACR Project GENIE is an international data-sharing consortium focused on generating an evidence base for precision cancer medicine by integrating clinical-grade cancer genomic data with clinical outcome data for tens of thousands of cancer patients treated at multiple institutions worldwide. In conjunction with the first public data rel... ... hiện toàn bộ
Tập 7 Số 8 - Trang 818-831 - 2017
Loss of PTEN Promotes Resistance to T Cell–Mediated ImmunotherapyAbstract
T cell–mediated immunotherapies are promising cancer treatments. However, most patients still fail to respond to these therapies. The molecular determinants of immune resistance are poorly understood. We show that loss of PTEN in tumor cells in preclinical models of melanoma inhibits T cell–mediated tumor killing and decreases T-cell traffic... ... hiện toàn bộ
Tập 6 Số 2 - Trang 202-216 - 2016
STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung AdenocarcinomaAbstract
KRAS is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously reported that STK11/LKB1 (KL) or TP53 (KP) comutations define distinct subgroups of KRAS-mutant LUAC. Here, we examine the efficacy of PD-1 inhibitors in these subgroups. Objective response rates to PD-1 blockade differed significantly among KL (7.4%), KP (... ... hiện toàn bộ
Tập 8 Số 7 - Trang 822-835 - 2018
Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid BiopsyAbstract
“Liquid biopsy” focusing on the analysis of circulating tumor cells (CTC) and circulating cell-free tumor DNA (ctDNA) in the blood of patients with cancer has received enormous attention because of its obvious clinical implications for personalized medicine. Analyses of CTCs and ctDNA have paved new diagnostic avenues and are, to date, the c... ... hiện toàn bộ
Tập 6 Số 5 - Trang 479-491 - 2016
MYC, Metabolism, and CancerAbstract
The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC triggers selective gene expression amplification to promote cell growth and proliferation. Through its targets, MYC coordinates nutrient acquisition to produce ATP and key cel... ... hiện toàn bộ
Tập 5 Số 10 - Trang 1024-1039 - 2015