Cancer Discovery
SCOPUS (2011-2025)SCIE-ISI
2159-8274
2159-8290
Mỹ
Cơ quản chủ quản: American Association for Cancer Research Inc. , AMER ASSOC CANCER RESEARCH
Lĩnh vực:
Oncology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Cổng thông tin cBio Genomics về ung thư: Nền tảng mở cho khám phá dữ liệu genomics ung thư đa chiều Dịch bởi AI
Tập 2 Số 5 - Trang 401-404 - 2012
Tóm tắt Cổng thông tin cBio Genomics về ung thư (http://cbioportal.org) là một
nguồn tài nguyên truy cập mở để khám phá tương tác các bộ dữ liệu genomics ung
thư đa chiều, hiện đang cung cấp truy cập tới dữ liệu từ hơn 5.000 mẫu khối u
thuộc 20 nghiên cứu về ung thư. Cổng thông tin cBio Genomics về ung thư giảm
đáng kể rào cản giữa dữ liệu genomics phức tạp và các nhà nghiên cứu ung thư,
những ngư...
#Genomics ung thư #cổng thông tin cBio #dữ liệu đa chiều #nghiên cứu ung thư #bộ dữ liệu genomics #phân tử và thuộc tính lâm sàng
Hallmarks of Cancer: New Dimensions
Tập 12 Số 1 - Trang 31-46 - 2022
Abstract The hallmarks of cancer conceptualization is a heuristic tool for
distilling the vast complexity of cancer phenotypes and genotypes into a
provisional set of underlying principles. As knowledge of cancer mechanisms has
progressed, other facets of the disease have emerged as potential refinements.
Herein, the prospect is raised that phenotypic plasticity and disrupted
differentiation is a ...
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
Tập 8 Số 9 - Trang 1069-1086 - 2018
AbstractImmune checkpoint blockade is able to induce durable responses across
multiple types of cancer, which has enabled the oncology community to begin to
envision potentially curative therapeutic approaches. However, the remarkable
responses to immunotherapies are currently limited to a minority of patients and
indications, highlighting the need for more effective and novel approaches.
Indeed, ...
Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy
Tập 1 Số 1 - Trang 54-67 - 2011
Abstract Immune-regulated pathways influence multiple aspects of cancer
development. In this article we demonstrate that both macrophage abundance and
T-cell abundance in breast cancer represent prognostic indicators for
recurrence-free and overall survival. We provide evidence that response to
chemotherapy is in part regulated by these leukocytes; cytotoxic therapies
induce mammary epithelial cel...
Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research
Tập 4 Số 9 - Trang 998-1013 - 2014
Abstract Recently, there has been an increasing interest in the development and
characterization of patient-derived tumor xenograft (PDX) models for cancer
research. PDX models mostly retain the principal histologic and genetic
characteristics of their donor tumor and remain stable across passages. These
models have been shown to be predictive of clinical outcomes and are being used
for preclinica...
AACR Project GENIE: Powering Precision Medicine through an International Consortium
Tập 7 Số 8 - Trang 818-831 - 2017
Abstract The AACR Project GENIE is an international data-sharing consortium
focused on generating an evidence base for precision cancer medicine by
integrating clinical-grade cancer genomic data with clinical outcome data for
tens of thousands of cancer patients treated at multiple institutions worldwide.
In conjunction with the first public data release from approximately 19,000
samples, we descr...
Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy
Tập 6 Số 2 - Trang 202-216 - 2016
Abstract T cell–mediated immunotherapies are promising cancer treatments.
However, most patients still fail to respond to these therapies. The molecular
determinants of immune resistance are poorly understood. We show that loss of
PTEN in tumor cells in preclinical models of melanoma inhibits T cell–mediated
tumor killing and decreases T-cell trafficking into tumors. In patients, PTEN
loss correla...
STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma
Tập 8 Số 7 - Trang 822-835 - 2018
Abstract KRAS is the most common oncogenic driver in lung adenocarcinoma (LUAC).
We previously reported that STK11/LKB1 (KL) or TP53 (KP) comutations define
distinct subgroups of KRAS-mutant LUAC. Here, we examine the efficacy of PD-1
inhibitors in these subgroups. Objective response rates to PD-1 blockade
differed significantly among KL (7.4%), KP (35.7%), and K-only (28.6%) subgroups
(P < 0.0...
Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy
Tập 6 Số 5 - Trang 479-491 - 2016
Abstract “Liquid biopsy” focusing on the analysis of circulating tumor cells
(CTC) and circulating cell-free tumor DNA (ctDNA) in the blood of patients with
cancer has received enormous attention because of its obvious clinical
implications for personalized medicine. Analyses of CTCs and ctDNA have paved
new diagnostic avenues and are, to date, the cornerstones of liquid biopsy
diagnostics. The pr...
MYC, Metabolism, and Cancer
Tập 5 Số 10 - Trang 1024-1039 - 2015
Abstract The MYC oncogene encodes a transcription factor, MYC, whose broad
effects make its precise oncogenic role enigmatically elusive. The evidence to
date suggests that MYC triggers selective gene expression amplification to
promote cell growth and proliferation. Through its targets, MYC coordinates
nutrient acquisition to produce ATP and key cellular building blocks that
increase cell mass an...