Hallmarks of Cancer: New Dimensions
Tóm tắt
The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underlying principles. As knowledge of cancer mechanisms has progressed, other facets of the disease have emerged as potential refinements. Herein, the prospect is raised that phenotypic plasticity and disrupted differentiation is a discrete hallmark capability, and that nonmutational epigenetic reprogramming and polymorphic microbiomes both constitute distinctive enabling characteristics that facilitate the acquisition of hallmark capabilities. Additionally, senescent cells, of varying origins, may be added to the roster of functionally important cell types in the tumor microenvironment.
Cancer is daunting in the breadth and scope of its diversity, spanning genetics, cell and tissue biology, pathology, and response to therapy. Ever more powerful experimental and computational tools and technologies are providing an avalanche of “big data” about the myriad manifestations of the diseases that cancer encompasses. The integrative concept embodied in the hallmarks of cancer is helping to distill this complexity into an increasingly logical science, and the provisional new dimensions presented in this perspective may add value to that endeavor, to more fully understand mechanisms of cancer development and malignant progression, and apply that knowledge to cancer medicine.
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Tài liệu tham khảo
Barker, 2009, Crypt stem cells as the cells-of-origin of intestinal cancer, Nature, 457, 608, 10.1038/nature07602
Perekatt, 2018, SMAD4 suppresses WNT-driven dedifferentiation and oncogenesis in the differentiated gut epithelium, Cancer Res, 78, 4878, 10.1158/0008-5472.CAN-18-0043
Shih, 2001, Top-down morphogenesis of colorectal tumors, Proc Natl Acad Sci U S A, 98, 2640, 10.1073/pnas.051629398
Ordóñez-Morán, 2015, HOXA5 counteracts stem cell traits by inhibiting Wnt signaling in colorectal cancer, Cancer Cell, 28, 815, 10.1016/j.ccell.2015.11.001
Tan, 2015, Stemming colorectal cancer growth and metastasis: HOXA5 forces cancer stem cells to differentiate, Cancer Cell, 28, 683, 10.1016/j.ccell.2015.11.004
Köhler, 2017, Mouse cutaneous melanoma induced by mutant BRaf arises from expansion and dedifferentiation of mature pigmented melanocytes, Cell Stem Cell, 21, 679, 10.1016/j.stem.2017.08.003
Shah, 2010, A role for ATF2 in regulating MITF and melanoma development, PLoS Genet, 6, e1001258, 10.1371/journal.pgen.1001258
Claps, 2016, A transcriptionally inactive ATF2 variant drives melanomagenesis, Cell Rep, 15, 1884, 10.1016/j.celrep.2016.04.072
Saghafinia, 2021, Cancer cells retrace a stepwise differentiation program during malignant progression, Cancer Discov, 11, 2638, 10.1158/2159-8290.CD-20-1637
Yu, 2019, Defining multistep cell fate decision pathways during pancreatic development at single-cell resolution, EMBO J, 38, e100164, 10.15252/embj.2018100164
He, 1999, In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications, Oncogene, 18, 5278, 10.1038/sj.onc.1203088
Bots, 2014, Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors, Blood, 123, 1341, 10.1182/blood-2013-03-488114
Ferrara, 2001, Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia, Cancer Res, 61, 2
Kaufman, 2016, A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation, Science, 351, aad2197, 10.1126/science.aad2197
Morris, 2019, α-Ketoglutarate links p53 to cell fate during tumour suppression, Nature, 573, 595, 10.1038/s41586-019-1577-5
Saha, 2014, Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer, Nature, 513, 110, 10.1038/nature13441
Dang, 2017, Isocitrate dehydrogenase mutation and (R)-2-hydroxyglutarate: from basic discovery to therapeutics development, Annu Rev Biochem, 86, 305, 10.1146/annurev-biochem-061516-044732
Waitkus, 2018, Biological role and therapeutic potential of IDH mutations in cancer, Cancer Cell, 34, 186, 10.1016/j.ccell.2018.04.011
Jiang, 2016, MIST1 and PTF1 collaborate in feed-forward regulatory loops that maintain the pancreatic acinar phenotype in adult mice, Mol Cell Biol, 36, 2945, 10.1128/MCB.00370-16
Krah, 2019, Prevention and reversion of pancreatic tumorigenesis through a differentiation-based mechanism, Dev Cell, 50, 744, 10.1016/j.devcel.2019.07.012
Krah, 2015, The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma, eLife, 4, e07125, 10.7554/eLife.07125
Shi, 2013, Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia, Oncogene, 32, 1950, 10.1038/onc.2012.210
Kopp, 2012, Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma, Cancer Cell, 22, 737, 10.1016/j.ccr.2012.10.025
Julian, 2017, Direct reprogramming with SOX factors: masters of cell fate, Curr Opin Genet Dev, 46, 24, 10.1016/j.gde.2017.06.005
Grimm, 2020, The role of SOX family members in solid tumours and metastasis, Semin Cancer Biol, 67, 122, 10.1016/j.semcancer.2019.03.004
Mu, 2017, SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer, Science, 355, 84, 10.1126/science.aah4307
Von Hoff, 2009, Inhibition of the hedgehog pathway in advanced basal-cell carcinoma, N Engl J Med, 361, 1164, 10.1056/NEJMoa0905360
Biehs, 2018, A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition, Nature, 562, 429, 10.1038/s41586-018-0596-y
Boumahdi, 2020, The great escape: tumour cell plasticity in resistance to targeted therapy, Nat Rev Drug Discov, 19, 39, 10.1038/s41573-019-0044-1
Groves, 2021, Cancer Hallmarks Define a Continuum of Plastic Cell States between Small Cell Lung Cancer Archetypes [Internet]
LaFave, 2020, Epigenomic state transitions characterize tumor progression in mouse lung adenocarcinoma, Cancer Cell, 38, 212, 10.1016/j.ccell.2020.06.006
Marjanovic, 2020, Emergence of a high-plasticity cell state during lung cancer evolution, Cancer Cell, 38, 229, 10.1016/j.ccell.2020.06.012
Drapkin, 2020, Studying lineage plasticity one cell at a time, Cancer Cell, 38, 150, 10.1016/j.ccell.2020.07.001
Inoue, 2020, Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer [Internet]
Dravis, 2018, Epigenetic and transcriptomic profiling of mammary gland development and tumor models disclose regulators of cell state plasticity, Cancer Cell, 34, 466, 10.1016/j.ccell.2018.08.001
Malta, 2018, Machine learning identifies stemness features associated with oncogenic dedifferentiation, Cell, 173, 338, 10.1016/j.cell.2018.03.034
Miao, 2020, A dedicated evolutionarily conserved molecular network licenses differentiated cells to return to the cell cycle, Dev Cell, 55, 178, 10.1016/j.devcel.2020.07.005
De Blander, 2021, Cellular plasticity: a route to senescence exit and tumorigenesis, Cancers, 13, 4561, 10.3390/cancers13184561
Merrell, 2016, Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style, Nat Rev Mol Cell Biol, 17, 413, 10.1038/nrm.2016.24
Baylin, 2016, Epigenetic determinants of cancer, Cold Spring Harb Perspect Biol, 8, a019505, 10.1101/cshperspect.a019505
Flavahan, 2017, Epigenetic plasticity and the hallmarks of cancer, Science, 357, eaal2380, 10.1126/science.aal2380
Jones, 2016, Targeting the cancer epigenome for therapy, Nat Rev Genet, 17, 630, 10.1038/nrg.2016.93
Huang, 2012, Tumor progression: Chance and necessity in Darwinian and Lamarckian somatic (mutationless) evolution, Prog Biophys Mol Biol, 110, 69, 10.1016/j.pbiomolbio.2012.05.001
Darwiche, 2020, Epigenetic mechanisms and the hallmarks of cancer: an intimate affair, Am J Cancer Res, 10, 1954
Feng, 2021, 3D chromatin architecture and epigenetic regulation in cancer stem cells, Protein Cell, 12, 440, 10.1007/s13238-020-00819-2
Nam, 2021, Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics, Nat Rev Genet, 22, 3, 10.1038/s41576-020-0265-5
Bitman-Lotan, 2021, Nuclear organization and regulation of the differentiated state, Cell Mol Life Sci CMLS, 78, 3141, 10.1007/s00018-020-03731-4
Zeng, 2019, DNA methylation reprogramming during mammalian development, Genes, 10, 257, 10.3390/genes10040257
Hegde, 2019, Recent developments in transcriptional and translational regulation underlying long-term synaptic plasticity and memory, Learn Mem, 26, 307, 10.1101/lm.048769.118
Kim, 2017, Epigenetic regulation and chromatin remodeling in learning and memory, Exp Mol Med, 49, e281, 10.1038/emm.2016.140
Thienpont, 2016, Tumors smother their epigenome, Mol Cell Oncol, 3, e1240549, 10.1080/23723556.2016.1240549
Gameiro, 2018, Nutrient deprivation elicits a transcriptional and translational inflammatory response coupled to decreased protein synthesis, Cell Rep, 24, 1415, 10.1016/j.celrep.2018.07.021
Lin, 2020, Understanding the deadly silence of posterior fossa A ependymoma, Mol Cell, 78, 999, 10.1016/j.molcel.2020.05.020
Michealraj, 2020, Metabolic regulation of the epigenome drives lethal infantile ependymoma, Cell, 181, 1329, 10.1016/j.cell.2020.04.047
Bakir, 2020, EMT, MET, plasticity, and tumor metastasis, Trends Cell Biol, 30, 764, 10.1016/j.tcb.2020.07.003
Gupta, 2019, Phenotypic plasticity: driver of cancer initiation, progression, and therapy resistance, Cell Stem Cell, 24, 65, 10.1016/j.stem.2018.11.011
Lambert, 2021, Linking EMT programmes to normal and neoplastic epithelial stem cells, Nat Rev Cancer, 21, 325, 10.1038/s41568-021-00332-6
Lindner, 2020, EMT transcription factor ZEB1 alters the epigenetic landscape of colorectal cancer cells, Cell Death Dis, 11, 147, 10.1038/s41419-020-2340-4
Javaid, 2013, Dynamic chromatin modification sustains epithelial-mesenchymal transition following inducible expression of Snail-1, Cell Rep, 5, 1679, 10.1016/j.celrep.2013.11.034
Serrano-Gomez, 2016, Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications, Mol Cancer, 15, 18, 10.1186/s12943-016-0502-x
Skrypek, 2017, Epithelial-to-mesenchymal transition: epigenetic reprogramming driving cellular plasticity, Trends Genet TIG, 33, 943, 10.1016/j.tig.2017.08.004
Li, 2013, Hijacking the neuronal NMDAR signaling circuit to promote tumor growth and invasion, Cell, 153, 86, 10.1016/j.cell.2013.02.051
Li, 2018, GKAP acts as a genetic modulator of NMDAR signaling to govern invasive tumor growth, Cancer Cell, 33, 736, 10.1016/j.ccell.2018.02.011
Mohammadi, 2018, Mechanisms and impact of altered tumour mechanics, Nat Cell Biol, 20, 766, 10.1038/s41556-018-0131-2
Odenthal, 2016, Plasticity of tumor cell invasion: governance by growth factors and cytokines, Carcinogenesis, 37, 1117
Torres, 2016, The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity, Science, 353, aaf1644, 10.1126/science.aaf1644
Puram, 2017, Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer, Cell, 171, 1611, 10.1016/j.cell.2017.10.044
Kinker, 2020, Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity, Nat Genet, 52, 1208, 10.1038/s41588-020-00726-6
Murtha, 2016, Extraordinary cancer epigenomics: thinking outside the classical coding and promoter box, Trends Cancer, 2, 572, 10.1016/j.trecan.2016.08.004
Nebbioso, 2018, Cancer epigenetics: moving forward, PLoS Genet, 14, e1007362, 10.1371/journal.pgen.1007362
Tavernari, 2021, Non-genetic evolution drives lung adenocarcinoma spatial heterogeneity and progression, Cancer Discov, 11, 1490, 10.1158/2159-8290.CD-20-1274
Heyn, 2016, Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer, Genome Biol, 17, 11, 10.1186/s13059-016-0879-2
Saghafinia, 2018, Pan-cancer landscape of aberrant DNA methylation across human tumors, Cell Rep, 25, 1066, 10.1016/j.celrep.2018.09.082
Audia, 2016, Histone modifications and cancer, Cold Spring Harb Perspect Biol, 8, a019521, 10.1101/cshperspect.a019521
Corces, 2018, The chromatin accessibility landscape of primary human cancers, Science, 362, eaav1898, 10.1126/science.aav1898
Esteve-Puig, 2020, Writers, readers and erasers of RNA modifications in cancer, Cancer Lett, 474, 127, 10.1016/j.canlet.2020.01.021
Janin, 2020, Disruption of the RNA modifications that target the ribosome translation machinery in human cancer, Mol Cancer, 19, 70, 10.1186/s12943-020-01192-8
Hanahan, 2012, Accessories to the crime: functions of cells recruited to the tumor microenvironment, Cancer Cell, 21, 309, 10.1016/j.ccr.2012.02.022
Lu, 2020, Epigenetic therapy inhibits metastases by disrupting premetastatic niches, Nature, 579, 284, 10.1038/s41586-020-2054-x
Thomas, 2017, The host microbiome regulates and maintains human health: a primer and perspective for non-microbiologists, Cancer Res, 77, 1783, 10.1158/0008-5472.CAN-16-2929
Dzutsev, 2017, Microbes and cancer, Annu Rev Immunol, 35, 199, 10.1146/annurev-immunol-051116-052133
Helmink, 2019, The microbiome, cancer, and cancer therapy, Nat Med, 25, 377, 10.1038/s41591-019-0377-7
Sears, 2014, Microbes, microbiota, and colon cancer, Cell Host Microbe, 15, 317, 10.1016/j.chom.2014.02.007
Pleguezuelos-Manzano, 2020, Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli, Nature, 580, 269, 10.1038/s41586-020-2080-8
Okumura, 2021, Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion, Nat Commun, 12, 5674, 10.1038/s41467-021-25965-x
Salvi, 2021, Butyrate and the intestinal epithelium: modulation of proliferation and inflammation in homeostasis and disease, Cells, 10, 1775, 10.3390/cells10071775
Fessler, 2019, Exploring the emerging role of the microbiome in cancer immunotherapy, J Immunother Cancer, 7, 108, 10.1186/s40425-019-0574-4
Gopalakrishnan, 2018, The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy, Cancer Cell, 33, 570, 10.1016/j.ccell.2018.03.015
Zitvogel, 2018, The microbiome in cancer immunotherapy: diagnostic tools and therapeutic strategies, Science, 359, 1366, 10.1126/science.aar6918
Baruch, 2021, Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients, Science, 371, 602, 10.1126/science.abb5920
Davar, 2021, Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients, Science, 371, 595, 10.1126/science.abf3363
Griffin, 2021, Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy, Science, 373, 1040, 10.1126/science.abc9113
Mager, 2020, Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy, Science, 369, 1481, 10.1126/science.abc3421
Ansaldo, 2021, Control of immunity by the microbiota, Annu Rev Immunol, 39, 449, 10.1146/annurev-immunol-093019-112348
Zhang, 2021, Gut microbiome directs hepatocytes to recruit MDSCs and promote cholangiocarcinoma, Cancer Discov, 11, 1248, 10.1158/2159-8290.CD-20-0304
Ding, 2014, Dynamics and associations of microbial community types across the human body, Nature, 509, 357, 10.1038/nature13178
Byrd, 2021, Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers, J Exp Med, 218, e20200606, 10.1084/jem.20200606
Healy, 2019, The microbiome and oral cancer: more questions than answers, Oral Oncol, 89, 30, 10.1016/j.oraloncology.2018.12.003
Swaney, 2021, Living in your skin: microbes, molecules and mechanisms, Infect Immun, 89, e00695, 10.1128/IAI.00695-20
Willis, 2020, The human oral microbiome in health and disease: from sequences to ecosystems, Microorganisms, 8, 308, 10.3390/microorganisms8020308
Xu, 2020, Vaginal microbiomes and ovarian cancer: a review, Am J Cancer Res, 10, 743
Nejman, 2020, The human tumor microbiome is composed of tumor type-specific intracellular bacteria, Science, 368, 973, 10.1126/science.aay9189
Jin, 2019, Commensal microbiota promote lung cancer development via γδ T cells, Cell, 176, 998, 10.1016/j.cell.2018.12.040
Pushalkar, 2018, The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression, Cancer Discov, 8, 403, 10.1158/2159-8290.CD-17-1134
McAllister, 2019, The tumor microbiome in pancreatic cancer: bacteria and beyond, Cancer Cell, 36, 577, 10.1016/j.ccell.2019.11.004
Kadosh, 2020, The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic, Nature, 586, 133, 10.1038/s41586-020-2541-0
Birch, 2020, Senescence and the SASP: many therapeutic avenues, Genes Dev, 34, 1565, 10.1101/gad.343129.120
Faget, 2019, Unmasking senescence: context-dependent effects of SASP in cancer, Nat Rev Cancer, 19, 439, 10.1038/s41568-019-0156-2
Gorgoulis, 2019, Cellular senescence: defining a path forward, Cell, 179, 813, 10.1016/j.cell.2019.10.005
Lee, 2019, The dynamic nature of senescence in cancer, Nat Cell Biol, 21, 94, 10.1038/s41556-018-0249-2
Wang, 2020, Senescent cells in cancer therapy: friends or foes?, Trends Cancer, 6, 838, 10.1016/j.trecan.2020.05.004
Baker, 2016, Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan, Nature, 530, 184, 10.1038/nature16932
Ruhland, 2016, Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis, Nat Commun, 7, 11762, 10.1038/ncomms11762
Hwang, 2020, Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells, Cancer Lett, 490, 100, 10.1016/j.canlet.2020.06.019
Wang, 2020, Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence, Breast Cancer Res, 22, 103, 10.1186/s13058-020-01346-y
Amor, 2020, Senolytic CAR T cells reverse senescence-associated pathologies, Nature, 583, 127, 10.1038/s41586-020-2403-9
Aster, 2017, The varied roles of notch in cancer, Annu Rev Pathol, 12, 245, 10.1146/annurev-pathol-052016-100127