Cancer Discovery

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CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies
Cancer Discovery - Tập 11 Số 5 - Trang 1192-1211 - 2021
Dongrui Wang, Briana C. Prager, Ryan C. Gimple, Brenda Aguilar, Darya Alizadeh, Hongzhen Tang, Deguan Lv, Renate Starr, Alfonso Brito, Qiulian Wu, Leo J.Y. Kim, Zhixin Qiu, Lin Peng, Michael H. Lorenzini, Behnam Badie, Stephen J. Forman, Qi Xie, Christine E. Brown, Jeremy N. Rich
AbstractGlioblastoma (GBM) contains self-renewing GBM stem cells (GSC) potentially amenable to immunologic targeting, but chimeric antigen receptor (CAR) T-cell therapy has demonstrated limited clinical responses in GBM. Here, we interrogated molecular determinants of CAR-mediated GBM killing through whole-genome CRISPR screens in both CAR T...... hiện toàn bộ
MYC, Metabolism, and Cancer
Cancer Discovery - Tập 5 Số 10 - Trang 1024-1039 - 2015
Zachary E. Stine, Zandra E. Walton, Brian J. Altman, Annie L. Hsieh, Chi V. Dang
Abstract The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive. The evidence to date suggests that MYC triggers selective gene expression amplification to promote cell growth and proliferation. Through its targets, MYC coordinates nutrient acquisition to produce ATP and key cel...... hiện toàn bộ
Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma
Cancer Discovery - Tập 7 Số 9 - Trang 984-998 - 2017
Kondrashova, Olga, Nguyen, Minh, Shield-Artin, Kristy, Tinker, Anna V., Teng, Nelson N.H., Harrell, Maria I., Kuiper, Michael J., Ho, Gwo-Yaw, Barker, Holly, Jasin, Maria, Prakash, Rohit, Kass, Elizabeth M., Sullivan, Meghan R., Brunette, Gregory J., Bernstein, Kara A., Coleman, Robert L., Floquet, Anne, Friedlander, Michael, Kichenadasse, Ganessan, O'Malley, David M., Oza, Amit, Sun, James, Robillard, Liliane, Maloney, Lara, Bowtell, David, on behalf of the AOCS Study Group, Giordano, Heidi, Wakefield, Matthew J., Kaufmann, Scott H., Simmons, Andrew D., Harding, Thomas C., Raponi, Mitch, McNeish, Iain A., Swisher, Elizabeth M., Lin, Kevin K., Scott, Clare L.
The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non–Small Cell Lung Cancer
Cancer Discovery - Tập 4 Số 6 - Trang 662-673 - 2014
Luc Friboulet, Nanxin Li, Ryohei Katayama, Christian C. Lee, Justin F. Gainor, Adam S. Crystal, Pierre‐Yves Michellys, Mark M. Awad, Noriko Yanagitani, Sung Joon Kim, AnneMarie Culazzo Pferdekamper, Jie Li, Shailaja Kasibhatla, Frank F. Sun, Xiuying Sun, Su Hua, Peter McNamara, Sidra Mahmood, Elizabeth L. Lockerman, Naoya Fujita, Makoto Nishio, Jennifer L. Harris, Alice T. Shaw, Jeffrey A. Engelman
Abstract Non–small cell lung cancers (NSCLC) harboring anaplastic lymphoma kinase (ALK) gene rearrangements invariably develop resistance to the ALK tyrosine kinase inhibitor (TKI) crizotinib. Herein, we report the first preclinical evaluation of the next-generation ALK TKI, ceritinib (LDK378), in the setting of crizotinib resistance. An interrogatio...... hiện toàn bộ
Targeting Autophagy in Cancer: Recent Advances and Future Directions
Cancer Discovery - Tập 9 Số 9 - Trang 1167-1181 - 2019
Ravi K. Amaravadi, Alec C. Kimmelman, Jayanta Debnath
AbstractAutophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit the growth of established tu...... hiện toàn bộ
Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression
Cancer Discovery - Tập 3 Số 3 - Trang 294-307 - 2013
Yufang Wang, Sérgia Velho, Efsevia Vakiani, Shouyong Peng, Adam J. Bass, Gerald C. Chu, Jessica J. Gierut, James M. Bugni, Channing J. Der, Mark R. Philips, David B. Solit, Kevin M. Haigis
Abstract N-RAS is one member of a family of oncoproteins that are commonly mutated in cancer. Activating mutations in NRAS occur in a subset of colorectal cancers, but little is known about how the mutant protein contributes to the onset and progression of the disease. Using genetically engineered mice, we find that mutant N-RAS strongly promotes tum...... hiện toàn bộ
Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras-Driven Hematopoietic Transformation
Cancer Discovery - Tập 3 Số 9 - Trang 993-1001 - 2013
Jin Xu, Kevin M. Haigis, Ari Firestone, Megan E. McNerney, Qing Li, Elizabeth L. Davis, Shann-Ching Chen, Joy Nakitandwe, James R. Downing, Tyler Jacks, Michelle M. Le Beau, Kevin Shannon
Abstract Biochemical properties of Ras oncoproteins and their transforming ability strongly support a dominant mechanism of action in tumorigenesis. However, genetic studies unexpectedly suggested that wild-type (WT) Ras exerts tumor suppressor activity. Expressing oncogenic NrasG12D in the hematopoietic compartment of mice induces an aggressive myel...... hiện toàn bộ
Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities
Cancer Discovery - Tập 5 Số 8 - Trang 860-877 - 2015
Ferdinandos Skoulidis, Lauren A. Byers, Lixia Diao, Vassiliki A. Papadimitrakopoulou, Pan Tong, Julie Izzo, Carmen Behrens, Humam Kadara, Edwin R. Parra, Jaime Rodriguez Canales, Jianjun Zhang, Uma Giri, Jayanthi Gudikote, María Angélica Cortez, Chao Yang, You Hong Fan, Michael Peyton, Luc Girard, Kevin R. Coombes, Carlo Toniatti, Timothy P. Heffernan, Murim Choi, Garrett M. Frampton, Vincent A. Miller, John N. Weinstein, Roy S. Herbst, Kwok‐Kin Wong, Jianhua Zhang, Padmanee Sharma, Gordon B. Mills, Waun Ki Hong, John D. Minna, James P. Allison, P. Andrew Futreal, Jing Wang, Ignacio I. Wistuba, John V. Heymach
Abstract The molecular underpinnings that drive the heterogeneity of KRAS-mutant lung adenocarcinoma are poorly characterized. We performed an integrative analysis of genomic, transcriptomic, and proteomic data from early-stage and chemorefractory lung adenocarcinoma and identified three robust subsets of KRAS-mutant lung adenocarcinoma dominated, re...... hiện toàn bộ
Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
Cancer Discovery - Tập 8 Số 1 - Trang 49-58 - 2018
Yelena Y. Janjigian, Francisco Sánchez-Vega, Philip Jonsson, Walid K. Chatila, Jaclyn F. Hechtman, Geoffrey Y. Ku, Jamie C. Riches, Yaelle Tuvy, Ritika Kundra, Nancy Bouvier, Efsevia Vakiani, Jianjiong Gao, Zachary Heins, Benjamin Groß, David P. Kelsen, Liying Zhang, Vivian E. Strong, Mark Schattner, Hans Gerdes, Daniel G. Coit, Manjit S. Bains, Zsofia K. Stadler, Valerie W. Rusch, David R. Jones, Daniela Molena, Jinru Shia, Mark E. Robson, Marinela Capanu, Sumit Middha, Ahmet Zehir, David M. Hyman, Maurizio Scaltriti, Marc Ladanyi, Neal Rosen, David H. Ilson, Michael F. Berger, Laura H. Tang, Barry S. Taylor, David B. Solit, Nikolaus Schultz
Abstract The incidence of esophagogastric cancer is rapidly rising, but only a minority of patients derive durable benefit from current therapies. Chemotherapy as well as anti-HER2 and PD-1 antibodies are standard treatments. To identify predictive biomarkers of drug sensitivity and mechanisms of resistance, we implemented prospective tumor sequencin...... hiện toàn bộ
Cổng thông tin cBio Genomics về ung thư: Nền tảng mở cho khám phá dữ liệu genomics ung thư đa chiều Dịch bởi AI
Cancer Discovery - Tập 2 Số 5 - Trang 401-404 - 2012
Ethan Cerami, Jianjiong Gao, Uğur Doğrusöz, Benjamin Groß, S. Onur Sumer, Bülent Arman Aksoy, Anders J. Skanderup, Caitlin J. Byrne, Michael Heuer, Erik Larsson, Yevgeniy Antipin, Boris Reva, Arthur P. Goldberg, Chris Sander, Nikolaus Schultz
Tóm tắt Cổng thông tin cBio Genomics về ung thư (http://cbioportal.org...... hiện toàn bộ
#Genomics ung thư #cổng thông tin cBio #dữ liệu đa chiều #nghiên cứu ung thư #bộ dữ liệu genomics #phân tử và thuộc tính lâm sàng
Tổng số: 92   
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