CNS Neuroscience and Therapeutics
SCOPUS (2008-2025)SCIE-ISI
1755-5949
1755-5930
Anh Quốc
Cơ quản chủ quản: WILEY , Wiley-Blackwell Publishing Ltd
Lĩnh vực:
Psychiatry and Mental HealthPharmacology (medical)PharmacologyPhysiology (medical)
Các bài báo tiêu biểu
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment
Tập 23 Số 1 - Trang 5-22 - 2017
SummaryNeurodegenerative diseases are a heterogeneous group of disorders that
are incurable and characterized by the progressive degeneration of the function
and structure of the central nervous system (CNS) for reasons that are not yet
understood. Neurodegeneration is the umbrella term for the progressive death of
nerve cells and loss of brain tissue. Because of their high energy requirements,
ne...
Inhibition of ferroptosis attenuates tissue damage and improves long‐term outcomes after traumatic brain injury in mice
Tập 25 Số 4 - Trang 465-475 - 2019
SummaryAimsFerroptosis, a new form of iron‐dependent programmed cell death, has
been shown to be involved in a range of diseases. However, the role of
ferroptosis in traumatic brain injury (TBI) has yet to be elucidated. We aimed
to investigate whether ferroptosis is induced after TBI and whether the
inhibition of ferroptosis would protect against traumatic brain injury in a
controlled cortical im...
Mechanisms of Efficacy of CBT for Cambodian Refugees with PTSD: Improvement in Emotion Regulation and Orthostatic Blood Pressure Response
Tập 15 Số 3 - Trang 255-263 - 2009
Based on the results of a randomized controlled trial, we examined a model of
the mechanisms of efficacy of culturally adapted cognitive‐behavior therapy
(CBT) for Cambodian refugees with pharmacology‐resistant posttraumatic stress
disorder (PTSD) and comordid orthostatic panic attacks (PAs). Twelve patients
were in the initial treatment condition, 12 in the delayed treatment condition.
The patien...
Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti‐inflammatory phenotype through STAT3 pathway
Tập 25 Số 12 - Trang 1353-1362 - 2019
AbstractAimsMicroglia and infiltrated macrophages play important roles in
inflammatory processes after ischemic stroke. Modulating microglia/macrophage
polarization from pro‐inflammatory phenotype to anti‐inflammatory state has been
suggested as a potential therapeutic approach in the treatment of ischemic
stroke. Melatonin has been shown to be neuroprotective in experimental stroke
models. Howeve...
Treating Major Depression by Creating Positive Expectations for the Future: A Pilot Study for the Effectiveness of Future‐Directed Therapy (FDT) on Symptom Severity and Quality of Life
Tập 18 Số 2 - Trang 102-109 - 2012
SUMMARYIntroduction:This nonrandomized pilot study assesses the efficacy of a
new future‐oriented form of therapy, known as future‐directed therapy (FDT), as
a treatment for patients with Major Depressive Disorder (MDD) in a naturalistic
hospital‐based outpatient psychiatry clinic. The study measured symptom severity
of depression and anxiety, in addition to quality of life pre‐ and
posttreatment....
Exercise, brain plasticity, and depression
Tập 26 Số 9 - Trang 885-895 - 2020
AbstractDepression is a common mental disorder characterized by high incidence,
high disability, and high fatality, causing great burden to the society,
families, and individuals. The changes in brain plasticity may be a main reason
for depression. Recent studies have shown that exercise plays a positive role in
depression, but systematic and comprehensive studies are lacking on brain
plasticity c...
Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3‐Nitropropionic Acid‐Induced Rat Model of Huntington's Disease
Tập 20 Số 1 - Trang 10-19 - 2014
SummaryAimHuntington's disease (HD) is an autosomal dominant disorder, for which
clinically available drugs offer only symptomatic relief. These prescription
drugs are not free of side effects, and the patients usually suffer from anxiety
and depression. We investigated quercetin, a dietary flavonoid with free radical
scavenging properties, for its beneficial potential if any, in 3‐nitropropionic
...
Pharmacotherapy for Alcohol Dependence: The 2015 Recommendations of the French Alcohol Society, Issued in Partnership with the European Federation of Addiction Societies
Tập 22 Số 1 - Trang 25-37 - 2016
SummaryBackgroundThe latest French good practice recommendations (GPRs) for the
screening, prevention, and treatment of alcohol misuse were recently published
in partnership with the European Federation of Addiction Societies (EUFAS). This
article aims to synthesize the GPRs focused on the pharmacotherapy of alcohol
dependence.MethodsA four‐member European steering committee defined the
questions ...
Antiepileptics Topiramate and Levetiracetam Alleviate Behavioral Deficits and Reduce Neuropathology in APP swe/PS 1dE9 Transgenic Mice
Tập 19 Số 11 - Trang 871-881 - 2013
SummaryBackgroundThe close relationship between epileptic seizure and
Alzheimer's disease (AD) has been demonstrated in the past decade. Valproic
acid, a traditional first‐line antiepileptic drug, exerted protective effects in
transgenic models of AD. It remains uncertain whether new antiepileptic drugs
could reverse neuropathology and behavioral deficits in AD transgenic
mice.AimsAPPswe/PS1dE9 tr...
Oligodendrocyte Pathophysiology and Treatment Strategies in Cerebral Ischemia
Tập 20 Số 7 - Trang 603-612 - 2014
SummaryOligodendrocytes (OLs), the myelin‐forming cells of the central nervous
system, form a functional unit with axons and play a crucial role in axonal
integrity. An episode of hypoxia–ischemia causes rapid and severe damage to
these particularly vulnerable cells via multiple pathways such as overactivation
of glutamate and ATP receptors, oxidative stress, and disruption of
mitochondrial functi...