CNS Neuroscience and Therapeutics

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Mechanisms of Efficacy of CBT for Cambodian Refugees with PTSD: Improvement in Emotion Regulation and Orthostatic Blood Pressure Response
CNS Neuroscience and Therapeutics - Tập 15 Số 3 - Trang 255-263 - 2009
Devon E. Hinton, Stefan G. Hofmann, Mark H. Pollack, Michael W. Otto
Based on the results of a randomized controlled trial, we examined a model of the mechanisms of efficacy of culturally adapted cognitive‐behavior therapy (CBT) for Cambodian refugees with pharmacology‐resistant posttraumatic stress disorder (PTSD) and comordid orthostatic panic attacks (PAs). Twelve patients were in the initial treatment condition, 12 in the delayed treatment condition. Th...... hiện toàn bộ
Antiepileptics Topiramate and Levetiracetam Alleviate Behavioral Deficits and Reduce Neuropathology in APPswe/PS1dE9 Transgenic Mice
CNS Neuroscience and Therapeutics - Tập 19 Số 11 - Trang 871-881 - 2013
Jian‐Quan Shi, Bian‐Rong Wang, You‐Yong Tian, Jun Xu, Li Gao, Shuli Zhao, Teng Jiang, Hong‐Guang Xie, Yingdong Zhang
SummaryBackgroundThe close relationship between epileptic seizure and Alzheimer's disease (AD) has been demonstrated in the past decade. Valproic acid, a traditional first‐line antiepileptic drug, exerted protective effects in transgenic models of ... hiện toàn bộ
Exercise, brain plasticity, and depression
CNS Neuroscience and Therapeutics - Tập 26 Số 9 - Trang 885-895 - 2020
Jinlei Zhao, Wanting Jiang, Xing Wang, Zhidong Cai, Zuhong Liu, Guo‐Rong Liu
AbstractDepression is a common mental disorder characterized by high incidence, high disability, and high fatality, causing great burden to the society, families, and individuals. The changes in brain plasticity may be a main reason for depression. Recent studies have shown that exercise plays a positive role in depression, but systematic and comprehensive studies ...... hiện toàn bộ
Expression Profile of Long Noncoding RNAs in Peripheral Blood Mononuclear Cells from Multiple Sclerosis Patients
CNS Neuroscience and Therapeutics - Tập 22 Số 4 - Trang 298-305 - 2016
Fang Zhang, Chao Gao, Xiaofeng Ma, Xiaolin Peng, Rongxin Zhang, Dexin Kong, Alain R. Simard, Junwei Hao
SummaryAimsLong noncoding RNAs (lncRNAs) play a key role in regulating immunological functions. Their impact on the chronic inflammatory disease multiple sclerosis (MS<...... hiện toàn bộ
Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3‐Nitropropionic Acid‐Induced Rat Model of Huntington's Disease
CNS Neuroscience and Therapeutics - Tập 20 Số 1 - Trang 10-19 - 2014
Joy Chakraborty, R. P. Singh, Debashis Dutta, Amit K. Naskar, Usha Rajamma, Kochupurackal P. Mohanakumar
SummaryAimHuntington's disease (HD) is an autosomal dominant disorder, for which clinically available drugs offer only symptomatic relief. These prescription drugs are not free of side effects, and the patients usually suffer from anxiety and depression. We investigated...... hiện toàn bộ
Treating Major Depression by Creating Positive Expectations for the Future: A Pilot Study for the Effectiveness of Future‐Directed Therapy (FDT) on Symptom Severity and Quality of Life
CNS Neuroscience and Therapeutics - Tập 18 Số 2 - Trang 102-109 - 2012
Jennice Vilhauer, Sabrina Young, Chanel Kealoha, Josefine Borrmann, Waguih William IsHak, Mark Hyman Rapaport, Narineh Hartoonian, Jim Mirocha
SUMMARYIntroduction:This nonrandomized pilot study assesses the efficacy of a new future‐oriented form of therapy, known as future‐directed therapy (FDT), as a treatment for patients with Major Depressive Disorder (MDD) in a naturalistic hospital‐based outpatient psychiatry clinic. The study measured symptom severity of depression and anxiety...... hiện toàn bộ
miR‐101 Acts as a Tumor Suppressor by Targeting Kruppel‐like Factor 6 in Glioblastoma Stem Cells
CNS Neuroscience and Therapeutics - Tập 21 Số 1 - Trang 40-51 - 2015
Yilong Yao, Jun Ma, Ping Wang, Yixue Xue, Zhen Li, Li‐Ni Zhao, Zhiqing Li, Tian‐Da Feng, Yunhui Liu
SummaryBackground and aimsGreat interest persists in useful therapeutic targets in glioblastoma (GBM). Deregulation of microRNAs (miRNAs) expression has been associated with cancer formation through alteratio...... hiện toàn bộ
Resting‐State Functional Brain Networks in Parkinson's Disease
CNS Neuroscience and Therapeutics - Tập 21 Số 10 - Trang 793-801 - 2015
Hugo C. Baggio, Bàrbara Segura, Carme Junqué
SummaryThe network approach is increasingly being applied to the investigation of normal brain function and its impairment. In the present review, we introduce the main methodological approaches employed for the analysis of resting‐state neuroimaging data in Parkinson's disease studies. We then summarize the results of recent studies that used a functional network ...... hiện toàn bộ
Inhibition of ferroptosis attenuates tissue damage and improves long‐term outcomes after traumatic brain injury in mice
CNS Neuroscience and Therapeutics - Tập 25 Số 4 - Trang 465-475 - 2019
Baoshu Xie, Yi‐Qin Wang, Yong Lin, Qing Mao, Junfeng Feng, Guoyi Gao, Jiyao Jiang
SummaryAimsFerroptosis, a new form of iron‐dependent programmed cell death, has been shown to be involved in a range of diseases. However, the role of ferroptosis in traumatic brain injury (TBI) has yet to be elucidated. We aimed to investigate whether ferroptosis is in...... hiện toàn bộ
Inhibition of phosphodiesterases as a strategy to achieve neuroprotection in Huntington's disease
CNS Neuroscience and Therapeutics - Tập 24 Số 4 - Trang 319-328 - 2018
Antonella Cardinale, Francesca R. Fusco
SummaryHuntington's disease (HD) is a fatal neurodegenerative condition, due to a mutation in the IT15 gene encoding for huntingtin. Currently, disease‐modifying therapy is not available for HD... hiện toàn bộ
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