Exercise, brain plasticity, and depression
Tóm tắt
Depression is a common mental disorder characterized by high incidence, high disability, and high fatality, causing great burden to the society, families, and individuals. The changes in brain plasticity may be a main reason for depression. Recent studies have shown that exercise plays a positive role in depression, but systematic and comprehensive studies are lacking on brain plasticity changes in depression. To further understand the antidepressive effect of exercise and the changes in brain plasticity, we retrieved related literatures using key words “depression,” “depressive disorder,” “exercise,” “brain plasticity,” “brain structure,” and “brain function” from the database of Web of Science, PubMed, EBSCO host, and CNKI, hoping to provide evidence for exercise in preventing and treating depression. Increase in exercise has been found negatively correlated with the risk of depression. Randomized controlled experiments have shown that aerobic exercise, resistance exercise, and mind‐body exercise can improve depressive symptoms and levels. The intensity and long‐term effect of exercise are now topical research issues. Exercise has been proven to reshape the brain structure of depression patients, activate the function of related brain areas, promote behavioral adaptation changes, and maintain the integrity of hippocampal and white matter volume, thus improving the brain neuroprocessing and delaying cognitive degradation in depression patients. Future studies are urgently needed to establish accurate exercise prescriptions for improving depressive symptoms, and studies on different depressive populations and studies using multimodal brain imaging combined with multiple analytical methods are also needed.
Từ khóa
Tài liệu tham khảo
Li QL, 2015, Longitudinal study of physical activity, cardiorespiratory fitness and risk of depression among college students, J Shandong Sport Univ, 4, 78
Nieuwenhuijsen K, 2014, Interventions to improve return to work in depressed people, Cochrane Database Syst Rev, 3, CD006237
Khorvash M, 2012, An investigation on the effect of strength and endurance training on depression, anxiety, and C‐reactive protein's inflammatory biomarker changes, J Res Med Sci, 17, 1072
Yang J, 2019, Effects of mind‐body exercise on depression: a meta‐analysis, Chin J Rehabil Theory Pract, 25, 1260
Li YL, 2012, Clinical observation on sitting Tai Chi exercise used for 30 cases of patients with depression after stroke, Chin Nurs Res, 26, 2254
Campbell S, 2004, The role of the hippocampus in the pathophysiology of major depression, J Psychiatry Neurosci, 29, 417
Zhang BW, 2014, White matter microstructure abnormalities of late‐life depression: a diffusion tensor imaging study, J Dalian Med Univ, 5, 440
Zhao Y, 2016, Brain cortical thickness abnormalities in first‐episode, never‐medicated, adult major depressive disorder patients, Chin J Radiol, 50, 647
Han ZL, 2019, Resting state functional magnetic resonance imaging in patients with first episode depression control subjects, World Latest Med Inf, 19, 25
Cui JM, 2018, Effects of aerobic exercise on the learning and memory and hippocampal dentate gyrus BDNF expression in chronic stress rats, J Cap Univ Phys Educ Sports, 30, 78
Courtright A, 2014, Aerobic Exercise and Hippocampal Plasticity in Young Adults with Depression, 1
Wang GP, 2006, The changes of brain wave characteristics and state‐trait anxiety of different state‐trait anxiety sufferers before and after doing Taijiquan exercise, J Phys Educ, 13, 43
Sharma VK, 2006, Effect of Sahaj Yoga on neuro‐cognitive functions in patients suffering from major depression, Indian J Physiol Pharmacol, 50, 375