Brain Tumor Pathology

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Droplet digital PCR assay for detecting TERT promoter mutations in patients with glioma
Brain Tumor Pathology - Tập 38 Số 3 - Trang 201-209 - 2021
Jun-ichi Adachi, Mitsuaki Shirahata, Tomonari Suzuki, Kazuhiko Mishima, Eita Uchida, Atsushi Sasaki, Ryo Nishikawa
Detection of SV40 T antigen genome in human gliomas
Brain Tumor Pathology - Tập 14 - Trang 125-129 - 1997
Satoshi O. Suzuki, Masahiro Mizoguchi, Toru Iwaki
The monkey polyomavirus simian virus 40 (SV40) has been reported to be associated with tumorigenesis of human neoplasms, mainly brain tumors. However, it remains controversial whether the virus really exists in human neoplasms and how the virus transforms human cells in vivo. We investigated the presence of SV40 T antigen genome in 33 human glioma tissue specimens from Japanese patients with diffe...... hiện toàn bộ
Frequent IDH1/2 mutations in intracranial chondrosarcoma: a possible diagnostic clue for its differentiation from chordoma
Brain Tumor Pathology - - 2012
Motohiro Arai, Sumihito Nobusawa, Hayato Ikota, Sunao Takemura, Yoichi Nakazato
Controversies over the diagnosis of oligodendroglioma: a report from the satellite workshop at the 4th international symposium of brain tumor pathology, Nagoya Congress Center, May 23, 2012
Brain Tumor Pathology - - 2013
Takashi Komori, Takanori Hirose, Makoto Shibuya, Hiroyoshi Suzuki, Shinya Tanaka, Atsushi Sasaki
Đại tế bào glioblastoma là một phân nhóm đặc biệt của glioma với đặc trưng là sự nhạy cảm với tổn thương DNA Dịch bởi AI
Brain Tumor Pathology - Tập 37 - Trang 5-13 - 2019
Kaoru Ogawa, Akira Kurose, Akihisa Kamataki, Kenichiro Asano, Kosuke Katayama, Hidekachi Kurotaki
Đại tế bào glioblastoma (GC-GBM) bao gồm những tế bào lớn có nhân đa hình thái. Trái ngược với GC-GBM, chúng tôi định nghĩa glioblastoma tế bào nhỏ đơn điệu (MS-GBM) là GBM gồm các tế bào nhỏ có nhân nhỏ đồng nhất và so sánh tổn thương DNA cũng như các đặc điểm bệnh lý khác. GC-GBM cho thấy sự xâm lấn tối thiểu (< 2 mm) và có các khu vực sarcomatous rải rác. TERTp là loại bình thường trong GC-GBM ...... hiện toàn bộ
#Giant cell glioblastoma; monotonic small GBM; DNA damage; OLIG2; TERTp; DSBs; tumor aggressiveness
Histone H3 K27M mutations in adult cerebellar high-grade gliomas
Brain Tumor Pathology - Tập 34 - Trang 113-119 - 2017
Satoshi Nakata, Sumihito Nobusawa, Tatsuya Yamazaki, Tadashi Osawa, Keishi Horiguchi, Yasuhiro Hashiba, Hiroyuki Yaoita, Nozomi Matsumura, Hayato Ikota, Junko Hirato, Yuhei Yoshimoto, Hideaki Yokoo
Adult cerebellar high-grade gliomas (HGG) are rare and their molecular basis has not been fully elucidated. Although a diffuse midline glioma H3 K27M-mutant, a recently characterized variant of HGG, was reported to occasionally occur in the cerebellum, adult cases were rarely tested for this mutation; only five mutant cases have been reported to date. It currently remains unknown whether H3 K27M-m...... hiện toàn bộ
A case of primary diffuse leptomeningeal gliomatosis
Brain Tumor Pathology - - 2014
Kouji Yamasaki, Kiyotaka Yokogami, Hajime Ohta, Shinji Yamashita, Hisao Uehara, Yuichiro Sato, Hideo Takeshima
Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare and fatal disease characterized by diffuse infiltration of the leptomeninges by neoplastic glial cells without evidence of tumor in the brain parenchyma or spinal cord. We report a 60-year-old man with PDLG. He suffered transient right hemiparesis and generalized seizures. MRI showed diffuse leptomeningeal thickening and enhancement throu...... hiện toàn bộ
Histopathologic and immunohistochemical profile of spinal glioblastoma: a study of six cases
Brain Tumor Pathology - Tập 28 - Trang 297-303 - 2011
Aparna Govindan, Shrijeet Chakraborti, Anita Mahadevan, Yasha T. Chickabasavaiah, Vani Santosh, S. K. Shankar
Spinal intramedullary glioblastomas are uncommon tumors and are known to have a very poor prognosis. Only a few studies in the literature have described their histopathological characteristics. We describe the detailed histopathological and immunohistochemical profiles of six cases of spinal glioblastoma. Most of the tumors were located in the cervical or cervicothoracic region. The majority of th...... hiện toàn bộ
Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma
Brain Tumor Pathology - Tập 40 - Trang 191-203 - 2023
Kaiyu Fan, Yifan Wei, Yunwei Ou, Jian Gong
To explore the characteristics of the immune microenvironment (IME) of medulloblastoma (MB) by four methods: flow cytometry (FCM), immunohistochemical (IHC), bulk RNA expression and single cell RNA sequencing (scRNA-seq), we collected the intraoperative specimens of MB, ependymoma (EPN), high-grade glioma (HGG), and low-grade glioma (LGG) to make a cross-cancer comparison. The specimens were subje...... hiện toàn bộ
Phenotypic changes associated with exogenous expression of p16INK4a in human glioma cells
Brain Tumor Pathology - Tập 18 - Trang 73-81 - 2001
Akio Noguchi, Nobuyuki Ito, Hiroki Sawa, Motoo Nagane, Mitsuhiro Hara, Isamu Saito
The tumor suppressorp16/CDKN2A/INK4a gene is frequently mutated, mostly by homozygous deletions in high-grade gliomas. Although the p16 protein suppresses cell proliferation primarily through inhibition of cell-cycle progression at the G1 phase, other phenotypic changes in glioma cells associated with p16INK4a alterations have not been fully described. To determine the roles of p16 alterations in ...... hiện toàn bộ
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