Brain Tumor Pathology

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Pathological features of highly invasive glioma stem cells in a mouse xenograft model
Brain Tumor Pathology - Tập 31 - Trang 77-84 - 2013
Hirokazu Sadahiro, Koichi Yoshikawa, Makoto Ideguchi, Koji Kajiwara, Aya Ishii, Eiji Ikeda, Yuji Owada, Yuki Yasumoto, Michiyasu Suzuki
Glioma stem cells (GSCs) may be a source of tumor progression and recurrence after multimodal therapy, because of their high invasive potential. The purpose of this study was to compare the invasive and migratory properties of GSCs and non-GSCs and examine the distribution of these cells in a mouse xenograft model. Three GSC lines, G144, Y02, and Y10, cultured from human glioblastoma, were used in...... hiện toàn bộ
Expression of Bcl-2, Bcl-x, and Bax proteins in astrocytomas in relation to patient survival
Brain Tumor Pathology - Tập 18 - Trang 123-129 - 2001
Shigeru Daido, Takashi Tamiya, Yasuhiro Ono, Kinya Terada, Shinichiro Mizumatsu, Takashi Ohmoto
The Bcl-2 family is composed of a group of related proteins that either prevent or promote apoptosis. This study was undertaken to assess the prognostic value of Bcl-2, Bcl-x, and Bax in patients with astrocytomas. Tissue samples from 104 astrocytomas (WHO grade 2, 21 cases; grade 3, 49 cases; grade 4, 34 cases), including 68 primary and 36 recurrent tumors, were examined immunohistochemically for...... hiện toàn bộ
Diencephalic pediatric low-grade glioma harboring the BRAF V600E mutation presenting with various morphologies in sequential biopsy specimens
Brain Tumor Pathology - - 2017
Yukitomo Ishi, Kanako C. Hatanaka, Shigeru Yamaguchi, Hiromi Fujita, Hiroaki Motegi, Hiroyuki Kobayashi, Shunsuke Terasaka, Kiyohiro Houkin
A primary DICER1-sarcoma with KRAS and TP53 mutations in a child with suspected ECCL
Brain Tumor Pathology - - 2022
Kaiyun Yang, Justin Wang, Nisha Kanwar, Anita Villani, Olufemi Ajani, Adam Fleming, Vikas Patil, Yasin Mamatjan, Qingxia Wei, David Malkin, Adam Shlien, Gelareh Zadeh, John Provias
Blood–brain barrier and blood–cerebrospinal fluid barrier in normal and pathological conditions
Brain Tumor Pathology - Tập 33 - Trang 89-96 - 2016
Masaki Ueno, Yoichi Chiba, Ryuta Murakami, Koichi Matsumoto, Machi Kawauchi, Ryuji Fujihara
Blood-borne substances can invade into the extracellular spaces of the brain via endothelial cells in sites without the blood–brain barrier (BBB), and can travel through the interstitial fluid (ISF) of the brain parenchyma adjacent to non-BBB sites. It has been shown that cerebrospinal fluid (CSF) drains directly into the blood via the arachnoid villi and also into lymph nodes via the subarachnoid...... hiện toàn bộ
Detection of failure of bevacizumab treatment for malignant glioma based on urinary matrix metalloproteinase activity
Brain Tumor Pathology - Tập 27 - Trang 89-94 - 2010
Shingo Takano, Ryota Mashiko, Satoru Osuka, Eiichi Ishikawa, Osamu Ohneda, Akira Matsumura
Although antiangiogenic treatment for malignant glioma using bevacizumab in combination with irinotecan chemotherapy has a promising effect on survival, the high incidence of increasing infiltrative tumors can be a problem in resistance to antiangiogenic therapy. In this study, we detected failure of bevacizumab treatment for malignant glioma through upregulation of metalloproteinase activity in t...... hiện toàn bộ
Supratentorial extraventricular anaplastic ependymoma in an adult with repeated intratumoral hemorrhage
Brain Tumor Pathology - Tập 31 - Trang 138-143 - 2013
Naotaka Iwamoto, Yasuo Murai, Yoichiro Yamamoto, Koji Adachi, Akira Teramoto
We report the case of a 61-year-old man with supratentorial extraventricular anaplastic ependymoma who presented with repeated intratumoral hemorrhage. The patient was admitted with headache. Computed tomography and magnetic resonance imaging showed an enhancing mass with intratumoral hemorrhage in the right temporal lobe. Gross total resection was performed. The tumor was well demarcated from the...... hiện toàn bộ
Immunohistochemical and ultrastructural review of six cases previously diagnosed as null cell PitNETs
Brain Tumor Pathology - Tập 40 - Trang 158-162 - 2023
Naoko Inoshita, Toyoki Yoshimoto, Yutaka Takazawa, Noriaki Fukuhara, Mitsuo Okada, Hiroshi Nishioka, Shozo Yamada
Pituitary neuroendocrine tumors (PitNETs) lacking lineage affiliation are termed “null cell” PitNETs (NCTs). NCTs are characterized as being immunonegative for pituitary hormones as well as transcription factors. We analyzed the ultrastructure and immunohistochemistry of six hormone-negative and transcription factor (TPIT, PIT1, SF1)-negative PitNETs, with less than 1% immunoreactive cells. Histol...... hiện toàn bộ
Non-promoter hypermethylation of zygote arrest 1 (ZAR1) in human brain tumors
Brain Tumor Pathology - Tập 28 - Trang 199-202 - 2011
Takao Watanabe, Kazunari Yachi, Takashi Ohta, Takao Fukushima, Atsuo Yoshino, Yoichi Katayama, Yui Shinojima, Tadashi Terui, Hiroki Nagase
Zygote arrest 1 (ZAR1) is a novel maternal-effect gene of crucial importance during the oocyte-to-embryo transition. Comprehensive methylation analysis of tumor-specific differently methylated regions in human malignant melanomas has recently led to the identification of non-promoter hypermethylation of the ZAR1 gene that had never been identified as an aberrant methylated region in any human tumo...... hiện toàn bộ
Two cases of primary supratentorial intracranial rhabdomyosarcoma with DICER1 mutation which may belong to a “spindle cell sarcoma with rhabdomyosarcoma-like feature, DICER1 mutant”
Brain Tumor Pathology - Tập 36 - Trang 174-182 - 2019
Maki Sakaguchi, Yoshiko Nakano, Mai Honda-Kitahara, Masashi Kinoshita, Shingo Tanaka, Masahiro Oishi, Kazuhiro Noguchi, Masaki Fukuda, Hideaki Maeba, Takuya Watanabe, Yutaka Hayashi, Hiroko Ikeda, Hiroshi Minato, Koichi Ichimura, Takayuki Nojima, Mitsutoshi Nakada
Rhabdomyosarcoma is the most common soft-tissue sarcoma affecting children and adolescents. It is defined as a malignant neoplasm characterized by morphologic, immunohistochemical, ultrastructural, or molecular genetic evidence of primary skeletal muscle differentiation, usually in the absence of any other pattern of differentiation. Primary intracranial rhabdomyosarcoma (PIRMS) is an extremely ra...... hiện toàn bộ
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