Diencephalic pediatric low-grade glioma harboring the BRAF V600E mutation presenting with various morphologies in sequential biopsy specimens

Yukitomo Ishi1, Kanako C. Hatanaka2, Shigeru Yamaguchi1, Hiromi Fujita2, Hiroaki Motegi1, Hiroyuki Kobayashi1, Shunsuke Terasaka1, Kiyohiro Houkin1
1Department of Neurosurgery, Hokkaido University School of Medicine, North 15 West 7, Kita-ku, Sapporo, 060-8638, Japan
2Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan

Tóm tắt

Từ khóa


Tài liệu tham khảo

Chappe C, Padovani L, Scavarda D et al (2013) Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression. Brain Pathol 23:574–583

Schindler G, Capper D, Meyer J et al (2011) Analysis of BRAF V600E mutation in 1320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol 121:397–405

Myung JK, Cho H, Park CK et al (2012) Analysis of the BRAF(V600E) mutation in central nervous system tumors. Transl Oncol 5:430–436

Lee D, Cho YH, Kang SY et al (2015) BRAF V600E mutations are frequent in dysembryoplastic neuroepithelial tumors and subependymal giant cell astrocytomas. J Surg Oncol 111:359–364

Ho CY, Mobley BC, Gordish-Dressman H et al (2015) A clinicopathologic study of diencephalic pediatric low-grade gliomas with BRAF V600 mutation. Acta Neuropathol 130:575–585

Collins VP, Jones DT, Giannini C (2015) Pilocytic astrocytoma: pathology, molecular mechanisms and markers. Acta Neuropathol 129:775–788

Rodriguez FJ, Lim KS, Bowers D et al (2013) Pathological and molecular advances in pediatric low-grade astrocytoma. Annu Rev Pathol 8:361–379

Burger PC, Scheithauer BW (2007) Tumors of the central nervous system. American Registry of Pathology, Washington

Becker AJWO, Figarella-Branger D, Blumcke I, Capper D (2016) WHO classification of tumours of the central nervous system. International Agency of Research on Cancer, Lyon

Preusser M, Laggner U, Haberler C et al (2006) Comparative analysis of NeuN immunoreactivity in primary brain tumours: conclusions for rational use in diagnostic histopathology. Histopathology 48:438–444

Dasgupta T, Olow AK, Yang X et al (2016) Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma. J Neurooncol 126:385–393

Capper D, Preusser M, Habel A et al (2011) Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol 122:11–19