Expression of Bcl-2, Bcl-x, and Bax proteins in astrocytomas in relation to patient survival

Brain Tumor Pathology - Tập 18 - Trang 123-129 - 2001
Shigeru Daido1, Takashi Tamiya1, Yasuhiro Ono1, Kinya Terada1, Shinichiro Mizumatsu1, Takashi Ohmoto1
1Department of Neurological Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

Tóm tắt

The Bcl-2 family is composed of a group of related proteins that either prevent or promote apoptosis. This study was undertaken to assess the prognostic value of Bcl-2, Bcl-x, and Bax in patients with astrocytomas. Tissue samples from 104 astrocytomas (WHO grade 2, 21 cases; grade 3, 49 cases; grade 4, 34 cases), including 68 primary and 36 recurrent tumors, were examined immunohistochemically for Bcl-2, Bcl-x, and Bax expression. Patient charts were reviewed for clinical presentation, and survival was followed. The mean values of the Bcl-2, Bcl-x, and Bax labeling indexes (LI) were 15.9±13.1%, 53.2±35.3%, and 25.9±23.2%, respectively. Statistical analysis showed that the Bcl-x LI of high-grade (grade 3 or 4) astrocytomas was higher than that of low-grade (grade 2) tumors (P=0.0064). There were no significant differences in patient survival between the high- and low-LI groups of Bcl-2, Bcl-x, and Bax. Since the mechanism and regulation of apoptosis are still unclear, it seems difficult to use the Bcl-2 family as a biological marker in predicting the prognosis of patients with astrocytomas.

Tài liệu tham khảo

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