Biophysics Reports

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Detecting peroxiredoxin hyperoxidation by one-dimensional isoelectric focusing
Biophysics Reports - Tập 1 Số 1 - Trang 14-17 - 2015
Zhenbo Cao, Neil J. Bulleid
Particle segmentation algorithm for flexible single particle reconstruction
Biophysics Reports - Tập 3 - Trang 43-55 - 2017
Qiang Zhou, Niyun Zhou, Hong-Wei Wang
As single particle cryo-electron microscopy has evolved to a new era of atomic resolution, sample heterogeneity still imposes a major limit to the resolution of many macromolecular complexes, especially those with continuous conformational flexibility. Here, we describe a particle segmentation algorithm towards solving structures of molecules composed of several parts that are relatively flexible ...... hiện toàn bộ
Direct structural evidence supporting a revolving mechanism in DNA packaging motors
Biophysics Reports - Tập 6 - Trang 155-158 - 2020
Yao-Gen Shu, Xiaolin Cheng
ExoHCR: một phương pháp nhạy cảm để xác định mức PD-L1 trên các exosome khối u phục vụ cho dự đoán liệu pháp miễn dịch Dịch bởi AI
Biophysics Reports - Tập 6 - Trang 290-298 - 2020
Lujun Hu, Wenjie Chen, Shurong Zhou, Guizhi Zhu
Liệu pháp miễn dịch ung thư đã đạt được những đột phá gần đây, bao gồm việc ức chế điểm kiểm soát miễn dịch (ICB) nhằm vào các điểm kiểm soát ức chế miễn dịch như protein chết tế bào được lập trình 1 (PD-1) và ligand chết tế bào được lập trình 1 (PD-L1). Tuy nhiên, hầu hết bệnh nhân ung thư không có phản ứng lâu dài với ICB. Để dự đoán phản ứng ICB nhằm phân loại bệnh nhân, phương pháp nhuộm miễn ...... hiện toàn bộ
#liệu pháp miễn dịch #ung thư #PD-L1 #exosome #phân loại bệnh nhân
An efficient two-step subcellular fractionation method for the enrichment of insulin granules from INS-1 cells
Biophysics Reports - Tập 1 - Trang 34-40 - 2015
Yan Chen, Zhiping Xia, Lifen Wang, Yong Yu, Pingsheng Liu, Eli Song, Tao Xu
Insulin is one of the key regulators for blood glucose homeostasis. More than 99% of insulin is secreted from the pancreatic β-cells. Within each β-cell, insulin is packaged and processed in insulin secretary granules (ISGs) before its exocytosis. Insulin secretion is a complicated but well-organized dynamic process that includes the budding of immature ISGs (iISGs) from the trans-Golgi network, i...... hiện toàn bộ
Identification of key genes and pathways for Alzheimer’s disease via combined analysis of genome-wide expression profiling in the hippocampus
Biophysics Reports - Tập 5 - Trang 98-109 - 2019
Mengsi Wu, Kechi Fang, Weixiao Wang, Wei Lin, Liyuan Guo, Jing Wang
In this study, combined analysis of expression profiling in the hippocampus of 76 patients with Alzheimer’s disease (AD) and 40 healthy controls was performed. The effects of covariates (including age, gender, postmortem interval, and batch effect) were controlled, and differentially expressed genes (DEGs) were identified using a linear mixed-effects model. To explore the biological processes, fun...... hiện toàn bộ
Proton transfer during class-A GPCR activation: do the CWxP motif and the membrane potential act in concert?
Biophysics Reports - - 2018
Xuejun C. Zhang, Ye Zhou, Chunlei Cao
Animal protein toxins: origins and therapeutic applications
Biophysics Reports - Tập 4 - Trang 233-242 - 2018
Na Chen, Siqi Xu, Yuhan Zhang, Feng Wang
Venomous animals on the earth have been found to be valuable resources for the development of therapeutics. Enzymatic and non-enzymatic proteins and peptides are the major components of animal venoms, many of which can target various ion channels, receptors, and membrane transporters. Compared to traditional small molecule drugs, natural proteins and peptides exhibit higher specificity and potency...... hiện toàn bộ
The road to a first-class research institute: creating an exceptional environment, recruiting outstanding scientists, producing high-impact work, and nurturing a culture of innovation—Preface to the 60th anniversary special issue
Biophysics Reports - Tập 4 - Trang 167-169 - 2018
Rui-Ming Xu
The microgravity enhanced polymer-mediated siRNA gene silence by improving cellular uptake
Biophysics Reports - Tập 6 - Trang 266-277 - 2020
Tongren Yang, Chanchan Yu, Changrong Wang, Chunhui Li, Mengjie Zhang, Xiaofan Luo, Yuhua Weng, Anjie Dong, Xiaoqiong Li, Yulin Deng, Yuanyu Huang
Microgravity (MG) effect is a weightlessness phenomenon caused by the distance from the ground or low gravity of other planets outside the earth’s atmosphere. The various effects of MG have been corroborated in human and animal studies and modeled in cell-based analogs. However,...... hiện toàn bộ
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