Biomolecules
SCOPUS (2011-2023)SCIE-ISI
2218-273X
Thụy Sĩ
Cơ quản chủ quản: MDPI , Multidisciplinary Digital Publishing Institute (MDPI)
Lĩnh vực:
BiochemistryMolecular Biology
Các bài báo tiêu biểu
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective StrategiesAbnormal deposition of misprocessed and aggregated proteins is a common final pathway of most neurodegenerative diseases, including Alzheimer’s disease (AD). AD is characterized by the extraneuronal deposition of the amyloid β (Aβ) protein in the form of plaques and the intraneuronal aggregation of the microtubule-associated protein tau in the form of filaments. Based on the biochemically ... ...
Tập 6 Số 1 - Trang 6
NF-kappaB Signaling in Chronic Inflammatory Airway DiseaseAsthma and chronic obstructive pulmonary disease (COPD) are obstructive airway disorders which differ in their underlying causes and phenotypes but overlap in patterns of pharmacological treatments. In both asthma and COPD, oxidative stress contributes to airway inflammation by inducing inflammatory gene expression. The redox-sensitive transcription factor, nuclear factor (NF)-kappaB (NF-κ... ...
Tập 5 Số 3 - Trang 1266-1283
Impact of Oxidative Stress on Exercising Skeletal MuscleIt is well established that muscle contractions during exercise lead to elevated levels of reactive oxygen species (ROS) in skeletal muscle. These highly reactive molecules have many deleterious effects, such as a reduction of force generation and increased muscle atrophy. Since the discovery of exercise-induced oxidative stress several decades ago, evidence has accumulated that ROS produc... ...
Tập 5 Số 2 - Trang 356-377
Antidiabetic Properties of Naringenin: A Citrus Fruit PolyphenolType 2 diabetes mellitus (T2DM) is a metabolic disease characterized by insulin resistance and hyperglycemia and is associated with personal health and global economic burdens. Current strategies/approaches of insulin resistance and T2DM prevention and treatment are lacking in efficacy resulting in the need for new preventative and targeted therapies. In recent years, epidemiological studi... ...
Tập 9 Số 3 - Trang 99
MYC-Driven Pathways in Breast Cancer SubtypesThe transcription factor MYC (MYC proto-oncogene, bHLH transcription factor) is an essential signaling hub in multiple cellular processes that sustain growth of many types of cancers. MYC regulates expression of RNA, both protein and non-coding, that control central metabolic pathways, cell death, proliferation, differentiation, stress pathways, and mechanisms of drug resistance. Activatio... ...
Tập 7 Số 3 - Trang 53
Melatonin and Its Protective Role against Biotic Stress Impacts on PlantsBiotic stress causes immense damage to agricultural products worldwide and raises the risk of hunger in many areas. Plants themselves tolerate biotic stresses via several pathways, including pathogen-associated molecular patterns (PAMPs), which trigger immunity and plant resistance (R) proteins. On the other hand, humans use several non-ecofriendly methods to control biotic stresses, such ... ...
Tập 10 Số 1 - Trang 54
4-Hydroxy-nonenal—A Bioactive Lipid Peroxidation ProductThis review on recent research advances of the lipid peroxidation product 4-hydroxy-nonenal (HNE) has four major topics: I. the formation of HNE in various organs and tissues, II. the diverse biochemical reactions with Michael adduct formation as the most prominent one, III. the endogenous targets of HNE, primarily peptides and proteins (here the mechanisms of covalent adduct formation are... ...
Tập 5 Số 4 - Trang 2247-2337
DOT1L and H3K79 Methylation in Transcription and Genomic StabilityThe organization of eukaryotic genomes into chromatin provides challenges for the cell to accomplish basic cellular functions, such as transcription, DNA replication and repair of DNA damage. Accordingly, a range of proteins modify and/or read chromatin states to regulate access to chromosomal DNA. Yeast Dot1 and the mammalian homologue DOT1L are methyltransferases that can add up to three... ...
Tập 8 Số 1 - Trang 11
Initial Events in Bacterial Transcription InitiationTranscription initiation is a highly regulated step of gene expression. Here, we discuss the series of large conformational changes set in motion by initial specific binding of bacterial RNA polymerase (RNAP) to promoter DNA and their relevance for regulation. Bending and wrapping of the upstream duplex facilitates bending of the downstream duplex into the active site cleft, nucleating ope... ...
Tập 5 Số 2 - Trang 1035-1062
Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and HealthThe Maillard reaction is a simple but ubiquitous reaction that occurs both in vivo and ex vivo during the cooking or processing of foods under high-temperature conditions, such as baking, frying, or grilling. Glycation of proteins is a post-translational modification that forms temporary adducts, which, on further crosslinking and rearrangement, form permanent residues known as advanced gl... ...
Tập 9 Số 12 - Trang 888