Biomolecules
SCOPUS (2011-2025)SCIE-ISI
2218-273X
Thụy Sĩ
Cơ quản chủ quản: MDPI , Multidisciplinary Digital Publishing Institute (MDPI)
Lĩnh vực:
BiochemistryMolecular Biology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
Tập 6 Số 1 - Trang 6
Abnormal deposition of misprocessed and aggregated proteins is a common final
pathway of most neurodegenerative diseases, including Alzheimer’s disease (AD).
AD is characterized by the extraneuronal deposition of the amyloid β (Aβ)
protein in the form of plaques and the intraneuronal aggregation of the
microtubule-associated protein tau in the form of filaments. Based on the
biochemically diverse ...
NF-kappaB Signaling in Chronic Inflammatory Airway Disease
Tập 5 Số 3 - Trang 1266-1283
Asthma and chronic obstructive pulmonary disease (COPD) are obstructive airway
disorders which differ in their underlying causes and phenotypes but overlap in
patterns of pharmacological treatments. In both asthma and COPD, oxidative
stress contributes to airway inflammation by inducing inflammatory gene
expression. The redox-sensitive transcription factor, nuclear factor (NF)-kappaB
(NF-κB), is a...
Impact of Oxidative Stress on Exercising Skeletal Muscle
Tập 5 Số 2 - Trang 356-377
It is well established that muscle contractions during exercise lead to elevated
levels of reactive oxygen species (ROS) in skeletal muscle. These highly
reactive molecules have many deleterious effects, such as a reduction of force
generation and increased muscle atrophy. Since the discovery of exercise-induced
oxidative stress several decades ago, evidence has accumulated that ROS produced
durin...
Antidiabetic Properties of Naringenin: A Citrus Fruit Polyphenol
Tập 9 Số 3 - Trang 99
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by insulin
resistance and hyperglycemia and is associated with personal health and global
economic burdens. Current strategies/approaches of insulin resistance and T2DM
prevention and treatment are lacking in efficacy resulting in the need for new
preventative and targeted therapies. In recent years, epidemiological studies
have ...
MYC-Driven Pathways in Breast Cancer Subtypes
Tập 7 Số 3 - Trang 53
The transcription factor MYC (MYC proto-oncogene, bHLH transcription factor) is
an essential signaling hub in multiple cellular processes that sustain growth of
many types of cancers. MYC regulates expression of RNA, both protein and
non-coding, that control central metabolic pathways, cell death, proliferation,
differentiation, stress pathways, and mechanisms of drug resistance. Activation
of MYC...
Melatonin and Its Protective Role against Biotic Stress Impacts on Plants
Tập 10 Số 1 - Trang 54
Biotic stress causes immense damage to agricultural products worldwide and
raises the risk of hunger in many areas. Plants themselves tolerate biotic
stresses via several pathways, including pathogen-associated molecular patterns
(PAMPs), which trigger immunity and plant resistance (R) proteins. On the other
hand, humans use several non-ecofriendly methods to control biotic stresses,
such as chemi...
4-Hydroxy-nonenal—A Bioactive Lipid Peroxidation Product
Tập 5 Số 4 - Trang 2247-2337
This review on recent research advances of the lipid peroxidation product
4-hydroxy-nonenal (HNE) has four major topics: I. the formation of HNE in
various organs and tissues, II. the diverse biochemical reactions with Michael
adduct formation as the most prominent one, III. the endogenous targets of HNE,
primarily peptides and proteins (here the mechanisms of covalent adduct
formation are describ...
DOT1L and H3K79 Methylation in Transcription and Genomic Stability
Tập 8 Số 1 - Trang 11
The organization of eukaryotic genomes into chromatin provides challenges for
the cell to accomplish basic cellular functions, such as transcription, DNA
replication and repair of DNA damage. Accordingly, a range of proteins modify
and/or read chromatin states to regulate access to chromosomal DNA. Yeast Dot1
and the mammalian homologue DOT1L are methyltransferases that can add up to
three methyl ...
Initial Events in Bacterial Transcription Initiation
Tập 5 Số 2 - Trang 1035-1062
Transcription initiation is a highly regulated step of gene expression. Here, we
discuss the series of large conformational changes set in motion by initial
specific binding of bacterial RNA polymerase (RNAP) to promoter DNA and their
relevance for regulation. Bending and wrapping of the upstream duplex
facilitates bending of the downstream duplex into the active site cleft,
nucleating opening of ...
Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health
Tập 9 Số 12 - Trang 888
The Maillard reaction is a simple but ubiquitous reaction that occurs both in
vivo and ex vivo during the cooking or processing of foods under
high-temperature conditions, such as baking, frying, or grilling. Glycation of
proteins is a post-translational modification that forms temporary adducts,
which, on further crosslinking and rearrangement, form permanent residues known
as advanced glycation ...