Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
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Bielschowsky, 1902, Die Silberimprägnation der Achsenzylinder, Neurol. Zentralb. (Leipzig), 13, 579
Alzheimer, 1907, Uber eine eigenartige Erkrankung der Hirnrinde, Allg Zeits Psychiatry Psych. Med., 64, 146
Jucker, M., Beyreuther, K., Haass, C., Nitsch, R., and Christen, Y. (2006). Alzheimer: 100 Years and Beyond, Springer.
Kidd, 1963, Paired helical filaments in electron microscopy of Alzheimer’s disease, Nature, 197, 192, 10.1038/197192b0
Terry, 1963, The fine structure of neurofibrillary tangles in Alzheimer’s disease, J. Neuropathol. Exp. Neurol., 22, 629, 10.1097/00005072-196310000-00005
Crowther, 1985, Image reconstruction of the Alzheimer paired helical filament, EMBO J., 4, 3661, 10.1002/j.1460-2075.1985.tb04132.x
Wischik, 1985, Subunit structure of paired helical filaments in Alzheimer’s disease, J. Cell Biol., 100, 1905, 10.1083/jcb.100.6.1905
Crowther, 1991, Straight and paired helical filaments in Alzheimer disease have a common structural unit, Proc. Natl. Acad. Sci. USA, 88, 2288, 10.1073/pnas.88.6.2288
Weingarten, 1975, A protein factor essential for microtubule assembly, Proc. Natl. Acad. Sci. USA, 72, 1858, 10.1073/pnas.72.5.1858
Cleveland, 1977, Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin, J. Mol. Biol., 116, 207, 10.1016/0022-2836(77)90213-3
Cleveland, 1977, Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly, J. Mol. Biol., 116, 227, 10.1016/0022-2836(77)90214-5
Pierre, 1983, Multisite phosphorylation of tau proteins from rat brain, Biochem. Biophys. Res. Commun., 115, 212, 10.1016/0006-291X(83)90991-9
Jameson, 1980, Inhibition of microtubule assembly by phosphorylation of microtubule-associated proteins, Biochemistry, 19, 2472, 10.1021/bi00552a027
Lindwall, 1984, Phosphorylation affects the ability of tau protein to promote microtubule assembly, J. Biol. Chem., 259, 5301, 10.1016/S0021-9258(17)42989-9
Binder, 1985, The distribution of tau in the mammalian central nervous system, J. Cell Biol., 101, 1371, 10.1083/jcb.101.4.1371
Papasozomenos, 1987, Phosphorylation determines two distinct species of Tau in the central nervous system, Cell Motil. Cytoskeleton, 8, 210, 10.1002/cm.970080303
Migheli, 1988, Light and electron microscope localization of the microtubule-associated tau protein in rat brain, J. Neurosci., 8, 1846, 10.1523/JNEUROSCI.08-06-01846.1988
Couchie, 1988, Expression of the mRNA for tau proteins during brain development and in cultured neurons and astroglial cells, J. Neurochem., 50, 1894, 10.1111/j.1471-4159.1988.tb02494.x
Brion, 1985, Mise en évidence immunologique de la protéine tau au niveau des lésions de dégénérescence neurofibrillaire de la maladie d’Alzheimer, Arch. Biol., 95, 229
Anderton, 1982, Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants, Nature, 298, 84, 10.1038/298084a0
Iqbal, 1986, Microtubule-associated protein tau. A component of Alzheimer paired helical filaments, J. Biol. Chem., 261, 6084, 10.1016/S0021-9258(17)38495-8
Iqbal, 1986, Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology, Proc. Natl. Acad. Sci. USA, 83, 4913, 10.1073/pnas.83.13.4913
Ihara, 1986, Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer’s disease, J. Biochem., 99, 1807, 10.1093/oxfordjournals.jbchem.a135662
Masters, 1985, Amyloid plaque core protein in Alzheimer disease and Down syndrome, Proc. Natl. Acad. Sci. USA, 82, 4245, 10.1073/pnas.82.12.4245
Masters, 1985, Neuronal origin of a cerebral amyloid: Neurofibrillary tangles of Alzheimer’s disease contain the same protein as the amyloid of plaque cores and blood vessels, EMBO J., 4, 2757, 10.1002/j.1460-2075.1985.tb04000.x
Mori, 1987, Ubiquitin is a component of paired helical filaments in Alzheimer’s disease, Science, 235, 1641, 10.1126/science.3029875
Perry, 1987, Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains, Proc. Natl. Acad. Sci. USA, 84, 3033, 10.1073/pnas.84.9.3033
Yen, 1983, Neurofibrillary tangles in senile dementia of the Alzheimer type share an antigenic determinant with intermediate filaments of the vimentin class, Am. J. Pathol., 113, 373
Yen, 1987, Alzheimer’s neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2, Am. J. Pathol., 126, 81
Wischik, 1988, Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease, Proc. Natl. Acad. Sci. USA, 85, 4506, 10.1073/pnas.85.12.4506
Wischik, 1988, Structural characterization of the core of the paired helical filament of Alzheimer disease, Proc. Natl. Acad. Sci. USA, 85, 4884, 10.1073/pnas.85.13.4884
Novak, 1989, Characterisation of the first monoclonal antibody against the pronase resistant core of the Alzheimer PHF, Prog. Clin. Biol. Res., 317, 755
Novak, 1991, Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51, Proc. Natl. Acad. Sci. USA, 88, 5837, 10.1073/pnas.88.13.5837
Resch, 1991, Design and synthesis of a potential affinity/cleaving reagent for beta-pleated sheet protein structures, Bioorg. Med. Chem. Lett., 1, 519, 10.1016/S0960-894X(01)80457-1
Lee, 1988, The primary structure and heterogeneity of tau protein from mouse brain, Science, 239, 285, 10.1126/science.3122323
Goedert, 1988, Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: Identification as the microtubule-associated protein tau, Proc. Natl. Acad. Sci. USA, 85, 4051, 10.1073/pnas.85.11.4051
Delacourte, 1986, Alzheimer’s disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments, J. Neurol. Sci., 76, 173, 10.1016/0022-510X(86)90167-X
Kosik, 1986, Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 83, 4044, 10.1073/pnas.83.11.4044
Nukina, 1986, One of the antigenic determinants of paired helical filaments is related to tau protein, J. Biochem., 99, 1541, 10.1093/oxfordjournals.jbchem.a135625
Wood, 1986, Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau), Proc. Natl. Acad. Sci. USA, 83, 4040, 10.1073/pnas.83.11.4040
Serrano, 1986, Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease, Biochem. Biophys. Res. Commun., 141, 790, 10.1016/S0006-291X(86)80242-X
Neve, 1986, Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2, Mol. Brain Res., 1, 271, 10.1016/0169-328X(86)90033-1
Donlon, 1987, Localization of microtubule-associated protein tau (MTBT1) to chromosome 17q21 (Abstract), Cytogenet. Cell Genet., 46, 607
Goedert, 1989, Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: Differential expression of tau protein mRNAs in human brain, EMBO J., 8, 393, 10.1002/j.1460-2075.1989.tb03390.x
Goedert, 1989, Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer’s disease, Neuron, 3, 519, 10.1016/0896-6273(89)90210-9
Goedert, 1990, Expression of separate isoforms of human tau protein: Correlation with the tau pattern in brain and effects on tubulin polymerization, EMBO J., 9, 4225, 10.1002/j.1460-2075.1990.tb07870.x
Goedert, 1992, Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system, Proc. Natl. Acad. Sci. USA, 89, 1983, 10.1073/pnas.89.5.1983
Sedmak, 2012, Human fetal tau protein isoform: Possibilities for Alzheimer’s disease treatment, Int. J. Biochem. Cell Biol., 44, 1290, 10.1016/j.biocel.2012.05.001
Greenberg, 1990, A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis, Proc. Natl. Acad. Sci. USA, 87, 5827, 10.1073/pnas.87.15.5827
Mulot, 1994, PHF-tau from Alzheimer’s brain comprises four species on SDS-PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase-3 beta, FEBS Lett., 349, 359, 10.1016/0014-5793(94)00702-0
Wolozin, 1986, A neuronal antigen in the brains of Alzheimer patients, Science, 232, 648, 10.1126/science.3083509
Flament, 1989, Abnormal tau species are produced during Alzheimer’s disease neurodegenerating process, FEBS Lett., 247, 213, 10.1016/0014-5793(89)81337-7
Lee, 1991, A68: A major subunit of paired helical filaments and derivatized forms of normal Tau, Science, 251, 675, 10.1126/science.1899488
Lai, 1995, Examination of phosphorylated tau protein as a PHF-precursor at early stage Alzheimer’s disease, Neurobiol. Aging, 16, 433, 10.1016/0197-4580(95)00041-C
Wischik, 1995, Quantitative analysis of tau protein in paired helical filament preparations: Implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer’s disease, Neurobiol. Aging, 16, 409, 10.1016/0197-4580(95)97327-D
Jakes, 1991, Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer’s disease, EMBO J., 10, 2725, 10.1002/j.1460-2075.1991.tb07820.x
Avila, J., Brandt, R., and Kosik, K. (1997). Brain Microtubule Associated Proteins: Modifications in Disease, Harwood Academic Publishers.
Gu, 1996, Tau is widely expressed in rat tissues, J. Neurochem., 67, 1235, 10.1046/j.1471-4159.1996.67031235.x
Qiang, 2006, Tau protects microtubules in the axon from severing by katanin, J. Neurosci., 26, 3120, 10.1523/JNEUROSCI.5392-05.2006
Takei, 2000, Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes, J. Cell Biol., 150, 989, 10.1083/jcb.150.5.989
Delacourte, 2000, Tau protein isoforms, phosphorylation and role in neurodegenerative disorders, Brain Res. Rev., 33, 95, 10.1016/S0165-0173(00)00019-9
Hasegawa, 1995, Hyperphosphorylation of tau in PHF, Neurobiol. Aging, 16, 365, 10.1016/0197-4580(95)00027-C
Bretteville, A., Ando, K., Ghestem, A., Loyens, A., Bégard, S., Beauvillain, J.-C., Sergeant, N., Hamdane, M., and Buée, L. (2009). Two-dimensional electrophoresis of tau mutants reveals specific phosphorylation pattern likely linked to early tau conformational changes. PLoS ONE, 4.
Diana, 2003, Phosphorylation pattern of tau associated with distinct changes of the growth cone cytoskeleton, Prog. Mol. Subcell. Biol., 32, 33, 10.1007/978-3-642-55557-2_2
Kingwell, 2015, Neurodegenerative disease: Targeting tau acetylation attenuates neurodegeneration, Nat. Rev. Drug Discov., 14, 748, 10.1038/nrd4768
Braak, 1991, Neuropathological stageing of Alzheimer-related changes, Acta Neuropathol., 82, 239, 10.1007/BF00308809
Braak, 2006, Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry, Acta Neuropathol., 112, 389, 10.1007/s00401-006-0127-z
Ding, 2008, Histone deacetylase 6 interacts with the microtubule-associated protein tau, J. Neurochem., 106, 2119, 10.1111/j.1471-4159.2008.05564.x
Huang, 1995, ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation, Neurosci. Lett., 192, 209, 10.1016/0304-3940(95)11649-H
Reynolds, 2008, Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cγ1, Grb2, and Src family kinases, J. Biol. Chem., 283, 18177, 10.1074/jbc.M709715200
Surridge, 1994, The difference in the binding of phosphatidylinositol distinguishes MAP2 from MAP2C and Tau, Biochemistry, 33, 8051, 10.1021/bi00192a009
Flanagan, 1997, The structure of divalent cation-induced aggregates of PIP2 and their alteration by gelsolin and tau, Biophys. J., 73, 1440, 10.1016/S0006-3495(97)78176-1
Himmelstein, 2012, Tau as a therapeutic target in neurodegenerative disease, Pharmacol. Ther., 136, 8, 10.1016/j.pharmthera.2012.07.001
Klein, 2002, Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau, J. Neurosci., 22, 698, 10.1523/JNEUROSCI.22-03-00698.2002
Jadhav, 2015, Tau-mediated synaptic damage in Alzheimer’s disease, Transl. Neurosci., 6, 214, 10.1515/tnsci-2015-0023
Dudilot, 2012, Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-d-aspartate receptor-dependent tau phosphorylation, J. Biol. Chem., 287, 32040, 10.1074/jbc.M112.401240
Ahmed, 2014, Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion, Neurobiol. Aging, 35, 2474, 10.1016/j.neurobiolaging.2014.05.005
Regan, 2015, Tau phosphorylation at serine 396 residue is required for hippocampal LTD, J. Neurosci., 35, 4804, 10.1523/JNEUROSCI.2842-14.2015
Sultan, 2011, Nuclear tau, a key player in neuronal DNA protection, J. Biol. Chem., 286, 4566, 10.1074/jbc.M110.199976
Perez, 2009, Tau-an inhibitor of deacetylase HDAC6 function, J. Neurochem., 109, 1756, 10.1111/j.1471-4159.2009.06102.x
Leyk, 2015, Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance, J. Mol. Neurosci., 55, 1031, 10.1007/s12031-014-0460-y
Davies, P., and Maloney, A.J. (1976). Selective loss of central cholinergic neurons in Alzheimer’s disease. Lancet.
Whitehouse, 1981, Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis, Ann. Neurol., 10, 122, 10.1002/ana.410100203
Glenner, 1984, Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein, Biochem. Biophys. Res. Commun., 120, 885, 10.1016/S0006-291X(84)80190-4
Wong, 1985, Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related, Proc. Natl. Acad. Sci. USA, 82, 8729, 10.1073/pnas.82.24.8729
Glenner, 1984, Alzheimer’s disease and Down’s syndrome: Sharing of a unique cerebrovascular amyloid fibril protein, Biochem. Biophys. Res. Commun., 122, 1131, 10.1016/0006-291X(84)91209-9
Goate, 1991, Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease, Nature, 349, 704, 10.1038/349704a0
Hardy, 1991, Amyloid deposition as the central event in the aetiology of Alzheimer’s disease, Trends Pharmacol. Sci., 12, 383, 10.1016/0165-6147(91)90609-V
Hardy, 1992, Alzheimer’s disease: The amyloid cascade hypothesis, Science, 256, 184, 10.1126/science.1566067
Blanquet, 1987, The beta amyloid protein (AD-AP) cDNA hybridizes in normal and Alzheimer individuals near the interface of 21q21 and q22.1, Ann. Génétique, 30, 68
Robakis, 1987, Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neuritic (senile) plaques of people with Alzheimer disease and Down syndrome, Lancet, 1, 384, 10.1016/S0140-6736(87)91754-5
Tanzi, 1987, The genetic defect causing familial Alzheimer’s disease maps on chromosome 21, Science, 235, 885, 10.1126/science.2880399
Goldgaber, 1987, Isolation, characterization, and chromosomal localization of human brain cDNA clones coding for the precursor of the amyloid of brain in Alzheimer’s disease, Down’s syndrome and aging, J. Neural Transm., 24, 23
Haan, 1990, Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch), Science, 248, 1120, 10.1126/science.1971458
Levy, 1990, Mutation of the Alzheimer’s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type, Science, 248, 1124, 10.1126/science.2111584
Lowenberg, 1934, Familial organic psychosis (Alzheimer’s type), Arch. Neurol., 31, 737, 10.1001/archneurpsyc.1934.02250040061004
Haines, 1992, Genetic evidence for a novel familial Alzheimer’s disease locus on chromosome 14, Nat. Genet., 2, 330, 10.1038/ng1292-330
Sherrington, 1995, Cloning of a gene bearing missense mutations in early-onset familial Alzheimer’s disease, Nature, 375, 754, 10.1038/375754a0
Schellenberg, 1992, Genetic linkage evidence for a familial Alzheimer’s disease locus on chromosome 14, Science, 258, 668, 10.1126/science.1411576
Wasco, 1995, Candidate gene for the chromosome 1 familial Alzheimer’s disease locus, Science, 269, 973, 10.1126/science.7638622
Czech, 2000, Presenilins and Alzheimer’s disease: Biological functions and pathogenic mechanisms, Prog. Neurobiol., 60, 363, 10.1016/S0301-0082(99)00033-7
Citron, 1997, Mutant presenilins of Alzheimer’s disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice, Nat. Med., 3, 67, 10.1038/nm0197-67
Okochi, 2002, Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1, EMBO J., 21, 5408, 10.1093/emboj/cdf541
De Strooper, B., Iwatsubo, T., and Wolfe, M.S. (2012). Presenilins and γ-secretase: Structure, function, and role in Alzheimer Disease. Cold Spring Harb. Perspect. Med.
Shen, 1997, Skeletal and CNS defects in Presenilin-1-deficient mice, Cell, 89, 629, 10.1016/S0092-8674(00)80244-5
Strittmatter, 1993, Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease, Proc. Natl. Acad. Sci. USA, 90, 1977, 10.1073/pnas.90.5.1977
Saunders, 1993, Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer’s disease, Neurology, 43, 1467, 10.1212/WNL.43.8.1467
Strittmatter, 2012, Old drug, new hope for Alzheimer’s disease, Science, 335, 1447, 10.1126/science.1220725
Mawuenyega, K.G., Sigurdson, W., Ovod, V., Munsell, L., Kasten, T., Morris, J.C., Yarasheski, K.E., and Bateman, R.J. (2010). Decreased clearance of CNS beta-amyloid in Alzheimer’s disease. Science.
Castellano, J.M., Kim, J., Stewart, F.R., Jiang, H., DeMattos, R.B., Patterson, B.W., Fagan, A.M., Morris, J.C., Mawuenyega, K.G., and Cruchaga, C. (2011). Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci. Transl. Med.
Qu, 2014, Beta-amyloid auto-antibodies are reduced in Alzheimer’s disease, J. Neuroimmunol., 274, 168, 10.1016/j.jneuroim.2014.06.017
Cacabelos, 2007, Pharmacogenetic basis for therapeutic optimization in Alzheimer’s disease, Mol. Diagn. Ther., 11, 385, 10.1007/BF03256262
Hollingworth, 2011, Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease, Nat. Genet., 43, 429, 10.1038/ng.803
Naj, 2011, Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer’s disease, Nat. Genet., 43, 436, 10.1038/ng.801
Lardenoije, 2015, The epigenetics of aging and neurodegeneration, Prog. Neurobiol., 131, 21, 10.1016/j.pneurobio.2015.05.002
Jonsson, 2013, Variant of TREM2 associated with the risk of Alzheimer’s disease, N. Engl. J. Med., 368, 107, 10.1056/NEJMoa1211103
Cruchaga, 2014, Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease, Nature, 505, 550, 10.1038/nature12825
Guerreiro, 2013, TREM2 variants in Alzheimer’s disease, N. Engl. J. Med., 368, 117, 10.1056/NEJMoa1211851
Arriagada, 1992, Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease, Neurology, 42, 631, 10.1212/WNL.42.3.631
Bierer, 1995, Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer’s disease, Arch. Neurol., 52, 81, 10.1001/archneur.1995.00540250089017
Bancher, 1989, Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer’s disease, Brain Res., 477, 90, 10.1016/0006-8993(89)91396-6
Braak, 1994, Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat, Neurosci. Lett., 171, 1, 10.1016/0304-3940(94)90589-4
Joshi, 2014, Neuroinflammation and Alzheimer’s disease: Lessons learned from 5-lypoxigenase, Transl. Neurosci., 5, 197, 10.2478/s13380-014-0225-7
Wang, 2011, BDNF-trkB signaling in late life cognitive decline and Alzheimer’s disease, Transl. Neurosci., 2, 91, 10.2478/s13380-011-0015-4
Pollock, N., Mirra, S., Binder, L., Hansen, L., and Wood, J. (1986). Filamentous aggregates in Pick’s disease, progressive supranuclear palsy, and Alzheimer’s disease share antigenic determinants with microtubule-associated protein, tau. Lancet, 204–205.
Sergeant, 2005, Tau protein as a differential biomarker of tauopathies, Biochim. Biophys. Acta, 1739, 179, 10.1016/j.bbadis.2004.06.020
Flament, 1991, Abnormal Tau proteins in progressive supranuclear palsy. Similarities and differences with the neurofibrillary degeneration of the Alzheimer type, Acta Neuropathol., 81, 591, 10.1007/BF00296367
Morgan, 1994, Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration, Am. J. Pathol., 145, 1496
Delacourte, 1996, Specific pathological tau protein variants characterize Pick’s disease, J. Neuropathol. Exp. Neurol., 55, 159, 10.1097/00005072-199602000-00004
Spillantini, 1998, Tau protein pathology in neurodegenerative diseases, Trends Neurosci., 21, 428, 10.1016/S0166-2236(98)01337-X
Wilhelmsen, 1994, Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21–22, Am. J. Hum. Genet., 55, 1159
Spillantini, 1997, Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments, Proc. Natl. Acad. Sci. USA, 94, 4113, 10.1073/pnas.94.8.4113
Murrell, 1997, Familial multiple-system tauopathy with presenile dementia is localized to chromosome 17, Am. J. Hum. Genet., 61, 1131, 10.1086/301594
Foster, 1997, Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference. Conference Participants, Ann. Neurol., 41, 706, 10.1002/ana.410410606
Spillantini, 1998, Mutation in the tau gene in familial multiple system tauopathy with presenile dementia, Proc. Natl. Acad. Sci. USA, 95, 7737, 10.1073/pnas.95.13.7737
Poorkaj, 1998, Tau is a candidate gene for chromosome 17 frontotemporal dementia, Ann. Neurol., 43, 815, 10.1002/ana.410430617
Hutton, 1998, Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17, Nature, 393, 702, 10.1038/31508
Hasegawa, 1998, Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly, FEBS Lett., 437, 207, 10.1016/S0014-5793(98)01217-4
Hong, 1998, Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17, Science, 282, 1914, 10.1126/science.282.5395.1914
1998, Cytoskeletal changes as an alternative view on pathogenesis of Alzheimer’s disease, Period. Biol., 100, 165
Bhatia, 2013, Untangling the role of tau in Alzheimer’s disease: A unifying hypothesis, Transl. Neurosci., 4, 115, 10.2478/s13380-013-0114-5
Dermaut, 2004, A novel presenilin 1 mutation associated with Pick’s disease but not beta-amyloid plaques, Ann. Neurol., 55, 617, 10.1002/ana.20083
Vandrovcova, 2009, Association of MAPT haplotype-tagging SNPs with sporadic Parkinson’s disease, Neurobiol. Aging, 30, 1477, 10.1016/j.neurobiolaging.2007.11.019
Dawson, 2001, Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice, J. Cell Sci., 114, 1179, 10.1242/jcs.114.6.1179
Terry, 1996, The pathogenesis of Alzheimer’s disease: An alternative to the amyloid hypothesis, J. Neuropathol. Exp. Neurol., 55, 1023, 10.1097/00005072-199655100-00001
Kopeikina, 2012, Soluble forms of tau are toxic in Alzheimer’s disease, Transl. Neurosci., 3, 223, 10.2478/s13380-012-0032-y
Harrington, 1991, Measurement of distinct immunochemical presentations of tau protein in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 88, 5842, 10.1073/pnas.88.13.5842
Novak, 1993, Molecular characterization of the minimal protease resistant tau unit of the Alzheimer’s disease paired helical filament, EMBO J., 12, 365, 10.1002/j.1460-2075.1993.tb05665.x
Wischik, 1996, Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines, Proc. Natl. Acad. Sci. USA, 93, 11213, 10.1073/pnas.93.20.11213
Harrington, 2015, Cellular models of aggregation-dependent template-directed proteolysis to characterize tau aggregation inhibitors for treatment of Alzheimer’s Disease, J. Biol. Chem., 290, 10862, 10.1074/jbc.M114.616029
Hrnkova, 2007, Neurodegeneration caused by expression of human truncated tau leads to progressive neurobehavioural impairment in transgenic rats, Brain Res., 1130, 206, 10.1016/j.brainres.2006.10.085
Zilka, 2006, Truncated tau from sporadic Alzheimer’s disease suffices to drive neurofibrillary degeneration in vivo, FEBS Lett., 580, 3582, 10.1016/j.febslet.2006.05.029
Wang, 2009, Tau fragmentation, aggregation and clearance: The dual role of lysosomal processing, Hum. Mol. Genet., 18, 4153, 10.1093/hmg/ddp367
Wischik, 2014, Tau-aggregation inhibitor therapy for Alzheimer’s disease, Biochem. Pharmacol., 88, 529, 10.1016/j.bcp.2013.12.008
Hurt, 2000, Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer’s disease, Am. J. Pathol., 157, 623, 10.1016/S0002-9440(10)64573-7
Callahan, 2002, Progressive reduction of synaptophysin message in single neurons in Alzheimer disease, J. Neuropathol. Exp. Neurol., 61, 384, 10.1093/jnen/61.5.384
Liu, 1996, Regional and laminar synaptic pathology in frontal lobe degeneration of non-Alzheimer type, Int. J. Geriatr. Psychiatry, 11, 47, 10.1002/(SICI)1099-1166(199601)11:1<47::AID-GPS285>3.0.CO;2-M
Suzuki, 1995, Neurofibrillary tangles in Niemann-Pick disease type C, Acta Neuropathol., 89, 227, 10.1007/BF00309338
Dujardin, S., Lécolle, K., Caillierez, R., Bégard, S., Zommer, N., Lachaud, C., Carrier, S., Dufour, N., Aurégan, G., and Winderickx, J. (2014). Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: Relevance to sporadic tauopathies. Acta Neuropathol. Commun.
Iba, 2013, Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer’s-like tauopathy, J. Neurosci., 33, 1024, 10.1523/JNEUROSCI.2642-12.2013
Frost, 2009, Propagation of tau misfolding from the outside to the inside of a cell, J. Biol. Chem., 284, 12845, 10.1074/jbc.M808759200
Polydoro, 2012, Propagation of tau pathology in a model of early Alzheimer’s disease, Neuron, 73, 685, 10.1016/j.neuron.2011.11.033
Liu, L., Drouet, V., Wu, J.W., Witter, M.P., Small, S.A., Clelland, C., and Duff, K. (2012). Trans-synaptic spread of tau pathology in vivo. PLoS ONE, 7.
Yanamandra, 2013, Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo, Neuron, 80, 402, 10.1016/j.neuron.2013.07.046
Rubinsztein, 2006, The roles of intracellular protein-degradation pathways in neurodegeneration, Nature, 443, 780, 10.1038/nature05291
Holmes, 2014, Proteopathic tau seeding predicts tauopathy in vivo, Proc. Natl. Acad. Sci. USA, 111, E4376, 10.1073/pnas.1411649111
Asai, 2015, Depletion of microglia and inhibition of exosome synthesis halt tau propagation, Nat. Neurosci., 18, 1584, 10.1038/nn.4132
Avila, 2015, AD genetic risk factors and tau spreading, Front. Aging Neurosci., 7, 1088, 10.3389/fnagi.2015.00099
Klafki, 2006, An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice, Proc. Natl. Acad. Sci. USA, 103, 9673, 10.1073/pnas.0602913103
Varghese, 2014, Green coffee as a novel agent for Alzheimer’s disease prevention by attenuating diabetes, Transl. Neurosci., 5, 111, 10.2478/s13380-014-0213-y
Berger, 2006, Rapamycin alleviates toxicity of different aggregate-prone proteins, Hum. Mol. Genet., 15, 433, 10.1093/hmg/ddi458
Troquier, 2012, Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: A suitable therapeutic approach, Curr. Alzheimer Res., 9, 397, 10.2174/156720512800492503
Dawidowitz, 2012, Targeting tau for Alzheimer’s disease and related neurodegenerative disorders, Drug Discov., 3, 16
Steinwachs, 2013, Treatment of Alzheimer’s Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study, J. Alzheimers. Dis., 33, 205
Baddeley, 2015, Complex disposition of methylthioninium redox forms determines efficacy in tau aggregation inhibitor therapy for Alzheimer’s disease, J. Pharmacol. Exp. Ther., 352, 110, 10.1124/jpet.114.219352
Wischik, 2015, Tau aggregation inhibitor therapy: An exploratory phase 2 study in mild or moderate Alzheimer’s disease, J. Alzheimers. Dis., 44, 705, 10.3233/JAD-142874
Grinberg, 2013, Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation, Acta Neuropathol., 125, 581, 10.1007/s00401-013-1080-2
Mohideen, S., Yamasaki, Y., Omata, Y., Tsuda, L., and Yoshiike, Y. (2015). Nontoxic singlet oxygen generator as a therapeutic candidate for treating tauopathies. Sci. Rep.
Melis, 2015, Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models, Behav. Pharmacol., 26, 353, 10.1097/FBP.0000000000000133
Stack, 2014, Methylene blue upregulates Nrf2/ARE genes and prevents tau-relatd neurotoxicity, Hum. Mol. Genet., 23, 3716, 10.1093/hmg/ddu080
Pakavathkumar, P., Sharma, G., Kaushal, V., Foveau, B., and LeBlanc, A. (2015). Methylene blue inhibits caspases by oxidation of the catalytic cysteine. Sci. Rep.
Hochgräfe, K., Sydow, A., Matenia, D., Cadinu, D., Könen, S., Petrova, O., Pickhardt, M., Goll, P., Morellini, F., and Mandelkow, E. (2015). Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta Neuropathol. Commun.
Bulic, 2010, Tau protein and tau aggregation inhibitors, Neuropharmacology, 59, 276, 10.1016/j.neuropharm.2010.01.016
Jun, G., Ibrahim-Verbaas, C.A., Vronskaya, M., Lambert, J.-C., Chung, J., Naj, A.C., Kunkle, B.W., Wang, L.-S., Bis, J.C., and Bellenguez, C. (2015). A novel Alzheimer disease locus located near the gene encoding tau protein. Mol. Psychiatry.