Biomolecules

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Obesity-Related Changes in Human Plasma Lipidome Determined by the Lipidyzer Platform
Biomolecules - Tập 11 Số 2 - Trang 326
Péter Pikó, László Pál, Sándor Szűcs, Zsigmond Kósa, János Sándor, Róza Ádány
Obesity is an increasing public health concern both in the developed and developing countries. Previous studies have demonstrated that considerable alterations in lipid metabolism and consequently marked changes in lipid profile are associated with the onset and progression of obesity-related complications. To characterize the full spectrum of obesity-induced changes in lipid metabolism, d...... hiện toàn bộ
Anandamide Revisited: How Cholesterol and Ceramides Control Receptor-Dependent and Receptor-Independent Signal Transmission Pathways of a Lipid Neurotransmitter
Biomolecules - Tập 8 Số 2 - Trang 31
Coralie Di Scala, Jacques Fantini, Nouara Yahi, Francisco J. Barrantes, Henri Chahinian
Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and arachidonic acid result in a slightly enhanced solubility in water and absence of an ionisable group for the neurotransmitter compared with the fatty acid. In this review, we first analyze the conformational flexibility of anandamide in aqueous...... hiện toàn bộ
Physicochemical Characterization and Antioxidant Activity Evaluation of Idebenone/Hydroxypropyl-β-Cyclodextrin Inclusion Complex †
Biomolecules - Tập 9 Số 10 - Trang 531
Valentina Venuti, Vincenza Crupi, Barbara Fazio, D. Majolino, Giuseppe Acri, Barbara Testagrossa, Rosanna Stancanelli, Federica De Gaetano, Agnese Gagliardi, Donatella Paolino, Giuseppe Floresta, Venerando Pistarà, Antonio Rescifina, Cinzia Anna Ventura
Idebenone (IDE) is an antioxidant drug active at the level of the central nervous system (CNS), whose poor water solubility limits its clinical application. An IDE/2-hydroxypropyl-β-cyclodextrin (IDE/HP-β-CD) inclusion complex was investigated by combining experimental methods and theoretical approaches. Furthermore, biological in vitro/ex vivo assays were performed. Phase solubility studi...... hiện toàn bộ
Changes in Ecophysiology, Osmolytes, and Secondary Metabolites of the Medicinal Plants of Mentha piperita and Catharanthus roseus Subjected to Drought and Heat Stress
Biomolecules - Tập 10 Số 1 - Trang 43
Haifa Abdulaziz S. Alhaithloul, Mona H. Soliman, K. L. Ameta, Mohamed A. El‐Esawi, Amr Elkelish
Global warming contributes to higher temperatures and reduces rainfall for most areas worldwide. The concurrent incidence of extreme temperature and water shortage lead to temperature stress damage in plants. Seeking to imitate a more natural field situation and to figure out responses of specific stresses with regard to their combination, we investigated physiological, biochemical, and me...... hiện toàn bộ
Exploring the Interactome of Cytochrome P450 2E1 in Human Liver Microsomes with Chemical Crosslinking Mass Spectrometry
Biomolecules - Tập 12 Số 2 - Trang 185
Dmitri R. Davydov, Bikash Dangi, Guihua Yue, Deepak Ahire, Bhagwat Prasad, Victor G. Zgoda
Aiming to elucidate the system-wide effects of the alcohol-induced increase in the content of cytochrome P450 2E1 (CYP2E1) on drug metabolism, we explored the array of its protein-protein interactions (interactome) in human liver microsomes (HLM) with chemical crosslinking mass spectrometry (CXMS). Our strategy employs membrane incorporation of purified CYP2E1 modified with photoreactive c...... hiện toàn bộ
Melatonin and Its Protective Role against Biotic Stress Impacts on Plants
Biomolecules - Tập 10 Số 1 - Trang 54
Mohamed Moustafa‐Farag, Abdulwareth Almoneafy, Ahmed Mahmoud, Amr Elkelish, Marino B. Arnao, Linfeng Li, Shaoying Ai
Biotic stress causes immense damage to agricultural products worldwide and raises the risk of hunger in many areas. Plants themselves tolerate biotic stresses via several pathways, including pathogen-associated molecular patterns (PAMPs), which trigger immunity and plant resistance (R) proteins. On the other hand, humans use several non-ecofriendly methods to control biotic stresses, such ...... hiện toàn bộ
Intracellular Peptides in Cell Biology and Pharmacology
Biomolecules - Tập 9 Số 4 - Trang 150
Christiane B. de Araujo, Andrea S. Heimann, Ricardo A. Remer, Lilian C. Russo, Alison Colquhoun, Fábio Luís Forti, Emer S. Ferro
Intracellular peptides are produced by proteasomes following degradation of nuclear, cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases generating a larger pool of peptides within cells. Thousands of intracellular peptides have been sequenced in plants, yeast, zebrafish, rodents, and in human cells and tissues. Relative levels of intracellular pept...... hiện toàn bộ
Assessment of the Pharmacological Properties and Phytochemical Profile of Bruguiera gymnorhiza (L.) Lam Using In Vitro Studies, In Silico Docking, and Multivariate Analysis
Biomolecules - Tập 10 Số 5 - Trang 731
Nabeelah Bibi Sadeer, Kouadio Ibrahime Sinan, Zoltán Cziáky, József Jekö, Gökhan Zengin, Rajesh Jeewon, Hassan H. Abdallah, Kannan R. R. Rengasamy, Mohamad Fawzi Mahomoodally
Bruguiera gymnorhiza (L.) Lam. is claimed to effectively manage a number of ailments including diabetes and associated complications. Nonetheless, no attempt has been made to delineate its pharmacological propensities and phytochemical profile. This study was designed to appraise the antioxidant and enzymatic inhibitory properties relevant to the management of diabetes mellitus, obesity, a...... hiện toàn bộ
Ectopic Expression of Glycine max GmNAC109 Enhances Drought Tolerance and ABA Sensitivity in Arabidopsis
Biomolecules - Tập 9 Số 11 - Trang 714
Nguyen Cao Nguyen, Xuan Lan Thi Hoang, Quang Nguyen, Ngo Xuan Binh, Yasuko Watanabe, Nguyễn Phương Thảo, Lam‐Son Phan Tran
The NAC (NAM, ATAF1/2, CUC2) transcription factors are widely known for their various functions in plant development and stress tolerance. Previous studies have demonstrated that genetic engineering can be applied to enhance drought tolerance via overexpression/ectopic expression of NAC genes. In the present study, the dehydration- and drought-inducible GmNAC109 from Glycine max was ectopi...... hiện toàn bộ
CAPE and Neuroprotection: A Review
Biomolecules - Tập 11 Số 2 - Trang 176
Marwa Balaha, Barbara De Filippis, Amelia Cataldi, Viviana di Giacomo
Propolis, a product of the honey bee, has been used in traditional medicine for many years. A hydrophobic bioactive polyphenolic ester, caffeic acid phenethyl ester (CAPE), is one of the most extensively investigated active components of propolis. Several studies have indicated that CAPE has a broad spectrum of pharmacological activities as anti-oxidant, anti-inflammatory, anti-viral, anti...... hiện toàn bộ
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