Biomolecules

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Measuring Treatment Response in Progressive Multiple Sclerosis—Considerations for Adapting to an Era of Multiple Treatment Options
Biomolecules - Tập 11 Số 9 - Trang 1342
Nik Krajnc, Thomas Berger, Gabriel Bsteh
Disability in multiple sclerosis accrues predominantly in the progressive forms of the disease. While disease-modifying treatment of relapsing MS has drastically evolved over the last quarter-century, the development of efficient drugs for preventing or at least delaying disability in progressive MS has proven more challenging. In that way, many drugs (especially disease-modifying treatmen...... hiện toàn bộ
Endolysosomal TRPMLs in Cancer
Biomolecules - Tập 11 Số 1 - Trang 65
Mengnan Xu, Xian‐Ping Dong
Lysosomes, the degradative endpoints and sophisticated cellular signaling hubs, are emerging as intracellular Ca2+ stores that govern multiple cellular processes. Dys-homeostasis of lysosomal Ca2+ is intimately associated with a variety of human diseases including cancer. Recent studies have suggested that the Ca2+-permeable channels Transient Receptor Potential (TRP) Mucolipins (TRPMLs, T...... hiện toàn bộ
Yuanhuacin and Related Anti-Inflammatory and Anticancer Daphnane Diterpenes from Genkwa Flos—An Overview
Biomolecules - Tập 12 Số 2 - Trang 192
Christian Bailly
The dried flower buds of the plant Daphne genkwa Sieb. et Zucc. have been largely used in traditional Chinese medicine for the treatment of inflammatory diseases. Numerous diterpenoids have been isolated from the Genkwa Flos (yuanhua in Chinese), including a series of daphnane-type diterpene designated as yuanhuacin (YC, often improperly designated as yuanhuacine) and analogues with a patr...... hiện toàn bộ
Phytochemical Analysis and Biological Activities of the Ethanolic Extract of Daphne sericea Vahl Flowering Aerial Parts Collected in Central Italy
Biomolecules - Tập 11 Số 3 - Trang 379
Claudio Frezza, Alessandro Venditti, Daniela De Vita, Fabio Sciubba, Pierpaolo Tomai, Marco Franceschin, Mirella Di Cecco, Giampiero Ciaschetti, Antonella Di Sotto, Annarita Stringaro, Marisa Colone, Alessandra Gentili, Mauro Serafini, Armandodoriano Bianco
In this paper, the first phytochemical analysis of the ethanolic extract of Daphne sericea Vahl flowering aerial parts collected in Italy and its biological activities were reported. Eleven compounds were identified i.e., α-linolenic acid (1), tri-linoleoyl-sn-glycerol (2), pheophorbide a ethyl ester (3), pilloin (4), sinensetin (5), yuanhuanin (6), rutamontine (7), syringin (8), p-coumari...... hiện toàn bộ
Role of Antioxidants in Alleviating Bisphenol A Toxicity
Biomolecules - Tập 10 Số 8 - Trang 1105
Shehreen Amjad, Md Saidur Rahman, Myung‐Geol Pang
Bisphenol A (BPA) is an oestrogenic endocrine disruptor widely used in the production of certain plastics, e.g., polycarbonate, hard and clear plastics, and epoxy resins that act as protective coating for food and beverage cans. Human exposure to this chemical is thought to be ubiquitous. BPA alters endocrine function, thereby causing many diseases in human and animals. In the last few dec...... hiện toàn bộ
Immunothrombosis in COVID-19: Implications of Neutrophil Extracellular Traps
Biomolecules - Tập 11 Số 5 - Trang 694
Brandon Bautista-Becerril, Rebeca Campi-Caballero, Samuel Sevilla-Fuentes, Laura M. Hernández-Regino, Alejandro Hanono, Al Flores-Bustamante, Julieta González-Flores, Carlos García-Ávila, Arnoldo Aquino‐Gálvez, Manuel Castillejos‐López, Armida Juárez-Cisneros, Ángel Camarena
SARS-CoV-2 is a member of the family of coronaviruses associated with severe outbreaks of respiratory diseases in recent decades and is the causative agent of the COVID-19 pandemic. The recognition by and activation of the innate immune response recruits neutrophils, which, through their different mechanisms of action, form extracellular neutrophil traps, playing a role in infection contro...... hiện toàn bộ
Obesity-Related Changes in Human Plasma Lipidome Determined by the Lipidyzer Platform
Biomolecules - Tập 11 Số 2 - Trang 326
Péter Pikó, László Pál, Sándor Szűcs, Zsigmond Kósa, János Sándor, Róza Ádány
Obesity is an increasing public health concern both in the developed and developing countries. Previous studies have demonstrated that considerable alterations in lipid metabolism and consequently marked changes in lipid profile are associated with the onset and progression of obesity-related complications. To characterize the full spectrum of obesity-induced changes in lipid metabolism, d...... hiện toàn bộ
Anandamide Revisited: How Cholesterol and Ceramides Control Receptor-Dependent and Receptor-Independent Signal Transmission Pathways of a Lipid Neurotransmitter
Biomolecules - Tập 8 Số 2 - Trang 31
Coralie Di Scala, Jacques Fantini, Nouara Yahi, Francisco J. Barrantes, Henri Chahinian
Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and arachidonic acid result in a slightly enhanced solubility in water and absence of an ionisable group for the neurotransmitter compared with the fatty acid. In this review, we first analyze the conformational flexibility of anandamide in aqueous...... hiện toàn bộ
Physicochemical Characterization and Antioxidant Activity Evaluation of Idebenone/Hydroxypropyl-β-Cyclodextrin Inclusion Complex †
Biomolecules - Tập 9 Số 10 - Trang 531
Valentina Venuti, Vincenza Crupi, Barbara Fazio, D. Majolino, Giuseppe Acri, Barbara Testagrossa, Rosanna Stancanelli, Federica De Gaetano, Agnese Gagliardi, Donatella Paolino, Giuseppe Floresta, Venerando Pistarà, Antonio Rescifina, Cinzia Anna Ventura
Idebenone (IDE) is an antioxidant drug active at the level of the central nervous system (CNS), whose poor water solubility limits its clinical application. An IDE/2-hydroxypropyl-β-cyclodextrin (IDE/HP-β-CD) inclusion complex was investigated by combining experimental methods and theoretical approaches. Furthermore, biological in vitro/ex vivo assays were performed. Phase solubility studi...... hiện toàn bộ
Impact of Oxidative Stress on Exercising Skeletal Muscle
Biomolecules - Tập 5 Số 2 - Trang 356-377
Peter Steinbacher, Peter Eckl
It is well established that muscle contractions during exercise lead to elevated levels of reactive oxygen species (ROS) in skeletal muscle. These highly reactive molecules have many deleterious effects, such as a reduction of force generation and increased muscle atrophy. Since the discovery of exercise-induced oxidative stress several decades ago, evidence has accumulated that ROS produc...... hiện toàn bộ
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