Biomolecules
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Measuring Treatment Response in Progressive Multiple Sclerosis—Considerations for Adapting to an Era of Multiple Treatment Options
Biomolecules - Tập 11 Số 9 - Trang 1342
Disability in multiple sclerosis accrues predominantly in the progressive forms
of the disease. While disease-modifying treatment of relapsing MS has
drastically evolved over the last quarter-century, the development of efficient
drugs for preventing or at least delaying disability in progressive MS has
proven more challenging. In that way, many drugs (especially disease-modifying
treatments) have...
Endolysosomal TRPMLs in Cancer
Biomolecules - Tập 11 Số 1 - Trang 65
Lysosomes, the degradative endpoints and sophisticated cellular signaling hubs,
are emerging as intracellular Ca2+ stores that govern multiple cellular
processes. Dys-homeostasis of lysosomal Ca2+ is intimately associated with a
variety of human diseases including cancer. Recent studies have suggested that
the Ca2+-permeable channels Transient Receptor Potential (TRP) Mucolipins
(TRPMLs, TRPML1-3)...
Yuanhuacin and Related Anti-Inflammatory and Anticancer Daphnane Diterpenes from Genkwa Flos—An Overview
Biomolecules - Tập 12 Số 2 - Trang 192
The dried flower buds of the plant Daphne genkwa Sieb. et Zucc. have been
largely used in traditional Chinese medicine for the treatment of inflammatory
diseases. Numerous diterpenoids have been isolated from the Genkwa Flos (yuanhua
in Chinese), including a series of daphnane-type diterpene designated as
yuanhuacin (YC, often improperly designated as yuanhuacine) and analogues with a
patronymic n...
Phytochemical Analysis and Biological Activities of the Ethanolic Extract of Daphne sericea Vahl Flowering Aerial Parts Collected in Central Italy
Biomolecules - Tập 11 Số 3 - Trang 379
In this paper, the first phytochemical analysis of the ethanolic extract of
Daphne sericea Vahl flowering aerial parts collected in Italy and its biological
activities were reported. Eleven compounds were identified i.e., α-linolenic
acid (1), tri-linoleoyl-sn-glycerol (2), pheophorbide a ethyl ester (3), pilloin
(4), sinensetin (5), yuanhuanin (6), rutamontine (7), syringin (8), p-coumaric
acid (...
Role of Antioxidants in Alleviating Bisphenol A Toxicity
Biomolecules - Tập 10 Số 8 - Trang 1105
Bisphenol A (BPA) is an oestrogenic endocrine disruptor widely used in the
production of certain plastics, e.g., polycarbonate, hard and clear plastics,
and epoxy resins that act as protective coating for food and beverage cans.
Human exposure to this chemical is thought to be ubiquitous. BPA alters
endocrine function, thereby causing many diseases in human and animals. In the
last few decades, st...
Immunothrombosis in COVID-19: Implications of Neutrophil Extracellular Traps
Biomolecules - Tập 11 Số 5 - Trang 694
SARS-CoV-2 is a member of the family of coronaviruses associated with severe
outbreaks of respiratory diseases in recent decades and is the causative agent
of the COVID-19 pandemic. The recognition by and activation of the innate immune
response recruits neutrophils, which, through their different mechanisms of
action, form extracellular neutrophil traps, playing a role in infection control
and tr...
Obesity-Related Changes in Human Plasma Lipidome Determined by the Lipidyzer Platform
Biomolecules - Tập 11 Số 2 - Trang 326
Obesity is an increasing public health concern both in the developed and
developing countries. Previous studies have demonstrated that considerable
alterations in lipid metabolism and consequently marked changes in lipid profile
are associated with the onset and progression of obesity-related complications.
To characterize the full spectrum of obesity-induced changes in lipid
metabolism, direct in...
Anandamide Revisited: How Cholesterol and Ceramides Control Receptor-Dependent and Receptor-Independent Signal Transmission Pathways of a Lipid Neurotransmitter
Biomolecules - Tập 8 Số 2 - Trang 31
Anandamide is a lipid neurotransmitter derived from arachidonic acid, a
polyunsaturated fatty acid. The chemical differences between anandamide and
arachidonic acid result in a slightly enhanced solubility in water and absence
of an ionisable group for the neurotransmitter compared with the fatty acid. In
this review, we first analyze the conformational flexibility of anandamide in
aqueous and mem...
Physicochemical Characterization and Antioxidant Activity Evaluation of Idebenone/Hydroxypropyl-β-Cyclodextrin Inclusion Complex †
Biomolecules - Tập 9 Số 10 - Trang 531
Idebenone (IDE) is an antioxidant drug active at the level of the central
nervous system (CNS), whose poor water solubility limits its clinical
application. An IDE/2-hydroxypropyl-β-cyclodextrin (IDE/HP-β-CD) inclusion
complex was investigated by combining experimental methods and theoretical
approaches. Furthermore, biological in vitro/ex vivo assays were performed.
Phase solubility studies showe...
Impact of Oxidative Stress on Exercising Skeletal Muscle
Biomolecules - Tập 5 Số 2 - Trang 356-377
It is well established that muscle contractions during exercise lead to elevated
levels of reactive oxygen species (ROS) in skeletal muscle. These highly
reactive molecules have many deleterious effects, such as a reduction of force
generation and increased muscle atrophy. Since the discovery of exercise-induced
oxidative stress several decades ago, evidence has accumulated that ROS produced
durin...
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