Biomolecules

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Obesity-Related Changes in Human Plasma Lipidome Determined by the Lipidyzer Platform
Biomolecules - Tập 11 Số 2 - Trang 326
Péter Pikó, László Pál, Sándor Szűcs, Zsigmond Kósa, János Sándor, Róza Ádány
Obesity is an increasing public health concern both in the developed and developing countries. Previous studies have demonstrated that considerable alterations in lipid metabolism and consequently marked changes in lipid profile are associated with the onset and progression of obesity-related complications. To characterize the full spectrum of obesity-induced changes in lipid metabolism, d...... hiện toàn bộ
Anandamide Revisited: How Cholesterol and Ceramides Control Receptor-Dependent and Receptor-Independent Signal Transmission Pathways of a Lipid Neurotransmitter
Biomolecules - Tập 8 Số 2 - Trang 31
Coralie Di Scala, Jacques Fantini, Nouara Yahi, Francisco J. Barrantes, Henri Chahinian
Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and arachidonic acid result in a slightly enhanced solubility in water and absence of an ionisable group for the neurotransmitter compared with the fatty acid. In this review, we first analyze the conformational flexibility of anandamide in aqueous...... hiện toàn bộ
Physicochemical Characterization and Antioxidant Activity Evaluation of Idebenone/Hydroxypropyl-β-Cyclodextrin Inclusion Complex †
Biomolecules - Tập 9 Số 10 - Trang 531
Valentina Venuti, Vincenza Crupi, Barbara Fazio, D. Majolino, Giuseppe Acri, Barbara Testagrossa, Rosanna Stancanelli, Federica De Gaetano, Agnese Gagliardi, Donatella Paolino, Giuseppe Floresta, Venerando Pistarà, Antonio Rescifina, Cinzia Anna Ventura
Idebenone (IDE) is an antioxidant drug active at the level of the central nervous system (CNS), whose poor water solubility limits its clinical application. An IDE/2-hydroxypropyl-β-cyclodextrin (IDE/HP-β-CD) inclusion complex was investigated by combining experimental methods and theoretical approaches. Furthermore, biological in vitro/ex vivo assays were performed. Phase solubility studi...... hiện toàn bộ
Intracellular Peptides in Cell Biology and Pharmacology
Biomolecules - Tập 9 Số 4 - Trang 150
Christiane B. de Araujo, Andrea S. Heimann, Ricardo A. Remer, Lilian C. Russo, Alison Colquhoun, Fábio Luís Forti, Emer S. Ferro
Intracellular peptides are produced by proteasomes following degradation of nuclear, cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases generating a larger pool of peptides within cells. Thousands of intracellular peptides have been sequenced in plants, yeast, zebrafish, rodents, and in human cells and tissues. Relative levels of intracellular pept...... hiện toàn bộ
Bullous Pemphigoid: Trigger and Predisposing Factors
Biomolecules - Tập 10 Số 10 - Trang 1432
Francesco Moro, Luca Fania, Jo Linda Sinagra, Adele Salemme, Giovanni Di Zenzo
Bullous pemphigoid (BP) is the most frequent autoimmune subepidermal blistering disease provoked by autoantibodies directed against two hemidesmosomal proteins: BP180 and BP230. Its pathogenesis depends on the interaction between predisposing factors, such as human leukocyte antigen (HLA) genes, comorbidities, aging, and trigger factors. Several trigger factors, such as drugs, thermal or e...... hiện toàn bộ
Influence of the Levels of Arsenic, Cadmium, Mercury and Lead on Overall Survival in Lung Cancer
Biomolecules - Tập 11 Số 8 - Trang 1160
Sandra Pietrzak, Janusz Wójcik, Piotr Baszuk, Wojciech Marciniak, Małgorzata Wojtyś, Tadeusz Dębniak, Cezary Cybulski, Jacek Gronwald, Jacek Alchimowicz, Bartłomiej Masojć, Piotr Waloszczyk, Darko Gajić, Tomasz Grodzki, Anna Jakubowska, Rodney J. Scott, Jan Lubiński, Marcin Lener
The effects of heavy metals on cancer risk have been widely studied in recent decades, but there is limited data on the effects of these elements on cancer survival. In this research, we examined whether blood concentrations of the heavy metals arsenic, cadmium, mercury and lead were associated with the overall survival of lung cancer patients. The study group consisted of 336 patients wit...... hiện toàn bộ
Function and Pathological Implications of Exon Junction Complex Factor Y14
Biomolecules - Tập 5 Số 2 - Trang 343-355
Tzu-Wei Chuang, Kuo-Ming Lee, Woan‐Yuh Tarn
Eukaryotic mRNA biogenesis involves a series of interconnected steps, including nuclear pre-mRNA processing, mRNA export, and surveillance. The exon-junction complex (EJC) is deposited on newly spliced mRNAs and coordinates several downstream steps of mRNA biogenesis. The EJC core protein, Y14, functions with its partners in nonsense-mediated mRNA decay and translational enhancement. Y14 p...... hiện toàn bộ
Chaperonin GroEL Reassembly: An Effect of Protein Ligands and Solvent Composition
Biomolecules - Tập 4 Số 2 - Trang 458-473
N. A. Ryabova, Victor Marchenkov, Н.В. Котова, Gennady V. Semisotnov
Chaperonin GroEL is a complex oligomeric heat shock protein (Hsp60) assisting the correct folding and assembly of other proteins in the cell. An intriguing question is how GroEL folds itself. According to the literature, GroEL reassembly is dependent on chaperonin ligands and solvent composition. Here we demonstrate dependence of GroEL reassembly efficiency on concentrations of the essenti...... hiện toàn bộ
Measuring Treatment Response in Progressive Multiple Sclerosis—Considerations for Adapting to an Era of Multiple Treatment Options
Biomolecules - Tập 11 Số 9 - Trang 1342
Nik Krajnc, Thomas Berger, Gabriel Bsteh
Disability in multiple sclerosis accrues predominantly in the progressive forms of the disease. While disease-modifying treatment of relapsing MS has drastically evolved over the last quarter-century, the development of efficient drugs for preventing or at least delaying disability in progressive MS has proven more challenging. In that way, many drugs (especially disease-modifying treatmen...... hiện toàn bộ
Endolysosomal TRPMLs in Cancer
Biomolecules - Tập 11 Số 1 - Trang 65
Mengnan Xu, Xian‐Ping Dong
Lysosomes, the degradative endpoints and sophisticated cellular signaling hubs, are emerging as intracellular Ca2+ stores that govern multiple cellular processes. Dys-homeostasis of lysosomal Ca2+ is intimately associated with a variety of human diseases including cancer. Recent studies have suggested that the Ca2+-permeable channels Transient Receptor Potential (TRP) Mucolipins (TRPMLs, T...... hiện toàn bộ
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