Biomechanics and Modeling in Mechanobiology

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Variations in mass transfer to single endothelial cells
Biomechanics and Modeling in Mechanobiology - Tập 8 - Trang 183-193 - 2008
Mark A. Van Doormaal, Ji Zhang, Shigeo Wada, James E. Shaw, Doyon Won, Myron I. Cybulsky, Chris M. Yip, C. Ross Ethier
Mass transfer between flowing blood and arterial mural cells (including vascular endothelial cells) may play an important role in atherogenesis. Endothelial cells are known to have an apical surface topography that is not flat, and hence mass transfer patterns to individual endothelial cells are likely affected by the local cellular topography. The purpose of this paper is to investigate the relat...... hiện toàn bộ
Three-dimensional flows in a hyperelastic vessel under external pressure
Biomechanics and Modeling in Mechanobiology - Tập 17 - Trang 1187-1207 - 2018
Sen Zhang, Xiaoyu Luo, Zongxi Cai
We study the collapsible behaviour of a vessel conveying viscous flows subject to external pressure, a scenario that could occur in many physiological applications. The vessel is modelled as a three-dimensional cylindrical tube of nonlinear hyperelastic material. To solve the fully coupled fluid–structure interaction, we have developed a novel approach based on the Arbitrary Lagrangian–Eulerian (A...... hiện toàn bộ
Longitudinal computational fluid dynamics study of stenosis and aneurysmal degeneration of an aortorenal bypass
Biomechanics and Modeling in Mechanobiology - Tập 19 Số 5 - Trang 1965-1975 - 2020
Zhuxiang Xiong, Yi Wang, Zeyang Mou, Yan Li, Zhan Li, Jun Wen, Ding Yuan, Tinghui Zheng
Refeeding reverses fasting-induced remodeling of afferent nerve activity in rat small intestine
Biomechanics and Modeling in Mechanobiology - Tập 18 - Trang 1915-1926 - 2019
Lingxia Bao, Jingbo Zhao, Donghua Liao, Guixue Wang, Hans Gregersen
Intestinal afferents play an important role in coordinating intestinal motor control. Fasting induces morpho-mechanical intestinal remodeling. This study aimed to characterize the effect of fasting and refeeding on mechanosensitivity in mesenteric afferent nerves in isolated Sprague–Dawley rat jejunum. A control group fed ad libitum, a group fasted for 7 days and a group refed 7 days after 7 days ...... hiện toàn bộ
Vital erythrocyte phenomena: what can theory, modeling, and simulation offer?
Biomechanics and Modeling in Mechanobiology - Tập 19 - Trang 1361-1388 - 2020
Robert J. Asaro, Qiang Zhu
We overview recent advances in the theoretical modeling, in particular via numerical simulation, of various vital human erythrocyte phenomena. The review is novel in how it interconnects a range of analysis within a coherent framework and focuses on extracting from them specific suggestions for experimental studies focused on, either validation of the analysis’ mechanistic basis, or uncovering her...... hiện toàn bộ
Propagation of material behavior uncertainty in a nonlinear finite element model of reconstructive surgery
Biomechanics and Modeling in Mechanobiology - Tập 17 Số 6 - Trang 1857-1873 - 2018
Taeksang Lee, Sergey Y. Turin, Arun K. Gosain, Ilias Bilionis, Adrián Buganza Tepole
Structure-induced nonlinear viscoelasticity of non-woven fibrous matrices
Biomechanics and Modeling in Mechanobiology - - 2016
Mohd Suhail Rizvi, Anupam Pal, Sovan Lal Das
Fibrous materials are widely utilized as tissue engineering scaffolds for tissue regeneration and other bioengineering applications. The structural as well as mechanical characteristics of the fibrous matrices under static and dynamic mechanical loading conditions influence the response of the cells. In this paper, we study the mechanical response of the non-woven fibrous matrices under oscillator...... hiện toàn bộ
Simulating single cell experiments in mechanical testing of adipocytes
Biomechanics and Modeling in Mechanobiology - Tập 14 - Trang 537-547 - 2014
Rona Katzengold, Naama Shoham, Dafna Benayahu, Amit Gefen
This study introduces new three-dimensional finite element cell modeling for simulating the structural, large deformation behavior of maturing adipocytes, based on empirically acquired geometrical properties of cultured adipocyte cells. We created models of adipocyte differentiation and maturation, which represented four stages along that process. The modeling focused on two specific and commonly ...... hiện toàn bộ
A phase-field model for fracture in biological tissues
Biomechanics and Modeling in Mechanobiology - Tập 15 - Trang 479-496 - 2015
Arun Raina, Christian Miehe
This work presents a recently developed phase-field model of fracture equipped with anisotropic crack driving force to model failure phenomena in soft biological tissues at finite deformations. The phase-field models present a promising and innovative approach to thermodynamically consistent modeling of fracture, applicable to both rate-dependent or rate-independent brittle and ductile failure mod...... hiện toàn bộ
A fast computational model for circulatory dynamics: effects of left ventricle–aorta coupling
Biomechanics and Modeling in Mechanobiology - Tập 22 - Trang 947-959 - 2023
Michael J. Moulton, Timothy W. Secomb
The course of diseases such as hypertension, systolic heart failure and heart failure with a preserved ejection fraction is affected by interactions between the left ventricle (LV) and the vasculature. To study these interactions, a computationally efficient, biophysically based mathematical model for the circulatory system is presented. In a four-chamber model of the heart, the LV is represented ...... hiện toàn bộ
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