Bioinformatics
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Penalized Cox regression analysis in the high-dimensional and low-sample size settings, with applications to microarray gene expression data
Bioinformatics - Tập 21 Số 13 - Trang 3001-3008 - 2005
UCHIME improves sensitivity and speed of chimera detectionAbstract
Motivation: Chimeric DNA sequences often form during polymerase chain reaction amplification, especially when sequencing single regions (e.g. 16S rRNA or fungal Internal Transcribed Spacer) to assess diversity or compare populations. Undetected chimeras may be misinterpreted as novel species, causing inflated estimates of diversity and spuri... ...
Bioinformatics - Tập 27 Số 16 - Trang 2194-2200 - 2011
InterProScan 5: genome-scale protein function classificationAbstract
Motivation: Robust large-scale sequence analysis is a major challenge in modern genomic science, where biologists are frequently trying to characterize many millions of sequences. Here, we describe a new Java-based architecture for the widely used protein function prediction software package InterProScan. Developments include improvements an... ...
Bioinformatics - Tập 30 Số 9 - Trang 1236-1240 - 2014
BEDTools: a flexible suite of utilities for comparing genomic featuresAbstract
Motivation: Testing for correlations between different sets of genomic features is a fundamental task in genomics research. However, searching for overlaps between features with existing web-based methods is complicated by the massive datasets that are routinely produced with current sequencing technologies. Fast and flexible tools are there... ...
Bioinformatics - Tập 26 Số 6 - Trang 841-842 - 2010
Two-stage designs for experiments with a large number of hypotheses
Bioinformatics - Tập 21 Số 19 - Trang 3771-3777 - 2005
A novel hybrid gene prediction method employing protein multiple sequence alignmentsAbstract Motivation: As improved DNA sequencing techniques have increased enormously the speed of producing new eukaryotic genome assemblies, the further development of automated gene prediction methods continues to be essential. While the classification of proteins into families is a task heavily relying on correct gene predictions, it can at the sa... ...
Bioinformatics - Tập 27 Số 6 - Trang 757-763 - 2011
QuickGO: a web-based tool for Gene Ontology searchingAbstract
Summary: QuickGO is a web-based tool that allows easy browsing of the Gene Ontology (GO) and all associated electronic and manual GO annotations provided by the GO Consortium annotation groups QuickGO has been a popular GO browser for many years, but after a recent redevelopment it is now able to offer a greater range of facilities including... ...
Bioinformatics - Tập 25 Số 22 - Trang 3045-3046 - 2009
The role of indirect connections in gene networks in predicting functionAbstract Motivation: Gene networks have been used widely in gene function prediction algorithms, many based on complex extensions of the ‘guilt by association’ principle. We sought to provide a unified explanation for the performance of gene function prediction algorithms in exploiting network structure and thereby simplify future analysis. Results: ... ...
Bioinformatics - Tập 27 Số 13 - Trang 1860-1866 - 2011
ProtTest 3: fast selection of best-fit models of protein evolutionAbstract
Summary: We have implemented a high-performance computing (HPC) version of ProtTest that can be executed in parallel in multicore desktops and clusters. This version, called ProtTest 3, includes new features and extended capabilities.
Availability: ProtTest 3 source code and binaries are freely available under... ...
Bioinformatics - Tập 27 Số 8 - Trang 1164-1165 - 2011
Tổng số: 211
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