Biochemistry and Cell Biology

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Physico-chemical and in-silico analysis of a phytocystatin purified fromBrassica junceacultivar RoAgro 5444
Biochemistry and Cell Biology - Tập 94 Số 6 - Trang 584-596 - 2016
Shumaila Khan, Sabahuddin Ahmad, Mohammad Imran Siddiqi, Bilqees Bano
This study describes the isolation and purification of a phytocystatin from seeds of Brassica juncea (Indian mustard; cultivar RoAgro 5444), which is an important oilseed crop both agriculturally and economically. The protein was purified by gel filtration chromatography with 24.3% yield and 204-fold purification, and visualised by 2D gel electrophoresis. The 18.1 kDa mustard cystatin was ...... hiện toàn bộ
Disruption of protein function by pathogenic mutations: common and uncommon mechanisms
Biochemistry and Cell Biology - Tập 97 Số 1 - Trang 46-57 - 2019
Mikko Taipale
Mutations in protein-coding regions underlie almost all Mendelian disorders, drive tumorigenesis, and contribute to susceptibility to common diseases. Despite the great diversity of diseases that are caused by coding mutations, the cellular processes that affect, and are affected by, pathogenic variants at the molecular level are fundamentally conserved. Experimental and computational app...... hiện toàn bộ
A Zn(II)-translocating P-type ATPase from <i>Proteus mirabilis</i>
Biochemistry and Cell Biology - Tập 76 Số 5 - Trang 787-790 - 1998
Christopher Rensing, Bharati Mitra, Barry P. Rosen
Effect of glutaraldehyde on hemoglobin: functional aspects and Mössbauer parameters
Biochemistry and Cell Biology - Tập 64 Số 1 - Trang 29-37 - 1986
Didier Guillochon, Mokambes Waran Vijayalakshmi, Atsu Thiam-Sow, Daniel Thomas, Alain Chevalier
Glutaraldehyde is widely used for the cross-linking of hemoglobin for blood substitute research or for technological purposes. The effects of this reagent on the biochemical properties of hemoglobin were correlated with Mössbauer data. Human hemoglobin was cross-linked by glutaraldehyde as soluble polymers and insoluble particles. Effects of cross-linking on oxygen affinity, oxidation–red...... hiện toàn bộ
DNases and apoptosis
Biochemistry and Cell Biology - Tập 78 Số 4 - Trang 405-414 - 2000
M.F. Counis, Alicia Torriglia
Here we review the different apoptotic DNases. From a functional point of view, DNases implicated in apoptosis may be classified into three groups: the Ca2+/Mg2+endonucleases, the Mg2+-endonucleases, and the cation-independent endonucleases. The first group includes DNase I which has no specificity for the linker region, DNase ...... hiện toàn bộ
Solid-state NMR studies of magnetically aligned phospholipid membranes: taming lanthanides for membrane protein studies
Biochemistry and Cell Biology - Tập 76 Số 2-3 - Trang 443-451 - 1998
R. Scott Prosser, V. B. Volkov, Irina Shiyanovskaya
The addition of lanthanides (Tm3+, Yb3+, Er3+, or Eu3+) to a solution of long-chain phospholipids such as dimyristoylphosphatidylcholine (DMPC) and short-chain phospholipids such as dihexanoylphosphatidylcholine (DHPC) is known to result in a bilayer phase in which the average bilayer normal aligns paralle...... hiện toàn bộ
Increases in DNA lesions and the DNA damage indicator Gadd45 following transient cerebral ischemia
Biochemistry and Cell Biology - Tập 75 Số 4 - Trang 383-392 - 1997
Sheng T. Hou, John P. MacManus
Nrf2 inducer and cncC overexpression attenuates neurodegeneration due to α-synuclein in Drosophila
Biochemistry and Cell Biology - Tập 93 Số 4 - Trang 351-358 - 2015
Bing Wang, Qingqing Liu, Hongyun Shan, Chunlin Xia, Zhaohui Liu
The study of the genes that are related to the pathogenesis of Parkinson’s disease (PD) will improve our understanding of the mechanisms that underlie the development of PD. α-Synuclein is a major protein component of Lewy bodies, which are characteristic structures of PD pathology. Mutations in α-synuclein are closely related to the early onset of autosomal dominant PD. Transgenic flies ...... hiện toàn bộ
Submitochondrial localization of kidney 25-hydroxycholecalciferol 1α-hydroxylase in vitamin D repleted weanling guinea pigs
Biochemistry and Cell Biology - Tập 65 Số 7 - Trang 673-676 - 1987
Xiaodong Yan, G Charette, EE Delvin
We have studied the submitochondrial localization of guinea-pig kidney 25-hydroxycholecalciferol 1α-hydroxylase. Treatment of the mitochondrial-enriched fraction with recrystallized digitonin produced mitoplasts bordered by a single membrane and with intact matrix. They contained nearly 90% of the 25-hydroxycholecalciferol 1α-hydroxylase activity and nearly 100% of the cytochrome-c: oxyge...... hiện toàn bộ
Mối quan hệ cấu trúc-chức năng của peptide kháng khuẩn Dịch bởi AI
Biochemistry and Cell Biology - Tập 76 Số 2-3 - Trang 235-246 - 1998
Paul M. Hwang, Hans J. Vogel
Peptide kháng khuẩn được sản xuất phổ biến trong tự nhiên. Nhiều peptide ngắn (6-50 amino acid) này có khả năng tiêu diệt vi khuẩn và nấm, tuy nhiên chúng thể hiện độc tính tối thiểu đối với tế bào động vật có vú. Tất cả peptide đều mang điện tích dương cao và có tính ưa nước thấp. Người ta tin rằng chúng hoạt động thông qua việc gắn kết không chuyên biệt với màng sinh học, mặc dù bản chấ...... hiện toàn bộ
#cấu trúc #peptide kháng khuẩn #NMR #màng #huyết tán.
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