DNases and apoptosis

Biochemistry and Cell Biology - Tập 78 Số 4 - Trang 405-414 - 2000
M.F. Counis1, Alicia Torriglia
1Unité 450 INSERM, Vieillissement et Pathologie de la Rétine, Paris, France. [email protected]

Tóm tắt

Here we review the different apoptotic DNases. From a functional point of view, DNases implicated in apoptosis may be classified into three groups: the Ca2+/Mg2+endonucleases, the Mg2+-endonucleases, and the cation-independent endonucleases. The first group includes DNase I which has no specificity for the linker region, DNase gamma which has some homology with DNase I, and other DNases which cleave DNA in the linker region. Both DNase I and DNase gamma have been cloned. The other nucleases of this category have dispersed molecular weights. Their sequences are unknown and it is difficult to determine their role(s) in apoptosis. It seems that different pathways are present and that these nucleases may be activated either by caspases or serine proteases. The caspase 3 activated DNase (CAD, CPAN, or DFF40) belongs to the Mg2+-dependent endonucleases. DNase II belongs to the third group of acid endonucleases or cation-independent DNases. We have shown the involvement of DNase II in lens cell differentiation. Recently, the molecular structure of two different enzymes has been elucidated, one of which has a signal peptide and appears to be secreted. The other, called L-DNase II, is an intracellular protein having two enzymatic activities; in its native form, it is an anti-protease, and after posttranslational modification, it becomes a nuclease.Key words: endonucleases, apoptosis, caspases, serine proteases.

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Tài liệu tham khảo

Arends M.J., 1990, Am. J. Pathol., 136, 593

Arends M.J., 1991, Int. Rev. Exp. Pathol., 32, 223, 10.1016/B978-0-12-364932-4.50010-1

Arruti C., 1995, Cell Death Diff., 2, 47

Bai J.Z., 1999, Biochem. J., 343, 53, 10.1042/bj3430053

Baker K.P., 1998, Gene, 215, 281, 10.1016/S0378-1119(98)00280-7

Barry M.A., 1992, Biochem. Biophys. Res. Comm., 186, 782, 10.1016/0006-291X(92)90814-2

Barry M.A., 1993, Arch. Biochem. Biophys., 300, 440, 10.1006/abbi.1993.1060

Barry M.A., 1993, Cancer Res., 55, 2349

Belmokhtar C.A., 2000, Exp. Cell Res., 254, 99, 10.1006/excr.1999.4737

Bernardi G., 1966, Biochim. Biophys. Acta, 129, 1, 10.1016/0005-2787(66)90002-5

Bernandi G., 1971, In The Enzymes, 4, 271, 10.1016/S1874-6047(08)60371-6

Bird C.H., 1998, Mol. Cell Biol., 18, 6387, 10.1128/MCB.18.11.6387

Counis M.F., 1998, Cell Death Diff., 5, 251, 10.1038/sj.cdd.4400351

Czene S., 1997, Biochemistry, 323, 337, 10.1042/bj3230337

Enari M., 1998, Nature (London), 391, 43, 10.1038/34112

Eastman A., 1994, Cell Death Diff., 1, 7

Famulski K.S., 1999, Cell Death Diff., 6, 281, 10.1038/sj.cdd.4400495

Furlong I.J., 1997, J. Cell Sci., 110, 653, 10.1242/jcs.110.5.653

Gaido M.L., 1991, J. Biol. Chem., 266, 580, 10.1016/S0021-9258(18)55102-4

Gorman A.M., 1999, Cell Death Diff., 6, 207, 10.1038/sj.cdd.4400481

Gottlieb R.A., 1996, Apoptosis, 1, 40, 10.1007/BF00142077

Gottlieb R.A., 1996, Proc. Natl. Acad. Sci. U. S.A., 93, 654, 10.1073/pnas.93.2.654

Halenbeck R., 1998, Curr. Biol., 8, 537, 10.1016/S0960-9822(98)79298-X

Hewish D.R., 1973, Biochem. Biophys. Res. Comm., 52, 504, 10.1016/0006-291X(73)90740-7

Hughes F.M., Jr., 1998, Cell Death Diff., 5, 1017, 10.1038/sj.cdd.4400418

Inohara N., 1998, EMBO J., 17, 2526, 10.1093/emboj/17.9.2526

Kluck R.M., 1994, Biochim. Biophys. Acta, 1223, 247, 10.1016/0167-4889(94)90233-X

Korpula-Mastalerz R., 1996, Acta Biochim. Polonica, 43, 419, 10.18388/abp.1996_4474

Krieser R.J., 1998, J. Biol. Chem., 273, 909, 10.1074/jbc.273.47.30909

Lack S.A., 1981, J. Biol. Chem., 256, 2644, 10.1016/S0021-9258(19)69662-6

Lebedeva L.G., 1995, Biochem. Molec. Biol. Inter., 35, 433

Li J., 1995, J. Biol. Chem., 270, 3203, 10.1074/jbc.270.7.3203

Liao T.H., 1985, J. Biol. Chem., 260, 708

Liao T.H., 1989, Biochim. Biophys. Acta, 1007, 15, 10.1016/0167-4781(89)90124-3

Liu Q.S., 1998, Biochemistry, 37, 134

Liu X., 1998, Proc. Natl. Acad. Sci. U.S.A., 95, 8461, 10.1073/pnas.95.15.8461

Montague J.W., 1994, J. Biol. Chem., 269, 877, 10.1016/S0021-9258(17)32249-4

Mukae N., 1998, Proc. Natl. Acad. Sci. U.S.A., 95, 9123, 10.1073/pnas.95.16.9123

Pandey S., 1997, Biochemistry, 36, 711, 10.1021/bi962387h

Peitsch M.C., 1993, EMBO J., 1, 371, 10.1002/j.1460-2075.1993.tb05666.x

Polzar B., 1991, Nucleic Acids Res., 18, 7151, 10.1093/nar/18.23.7151

Potempa J., 1988, J. Biol. Chem., 263, 7364, 10.1016/S0021-9258(18)68651-X

Ribeiro J.M., 1993, Biochemistry, 32, 9129, 10.1021/bi00086a018

Sakahira H., 1998, Nature (London), 391, 96, 10.1038/34214

Samejima K., 1998, Exp. Cell Res., 243, 453, 10.1006/excr.1998.4212

Segal-Bendirdjian E., 1995, Exp. Cell Res., 218, 201, 10.1006/excr.1995.1148

Shak S., 1990, Proc. Natl. Acad. Sci. U.S.A., 87, 9188, 10.1073/pnas.87.23.9188

Sharma K., 1998, Biochem. Biophys. Res. Comm., 242, 134, 10.1006/bbrc.1997.7933

Shiokawa D., 1997, Biochem. J., 326, 675, 10.1042/bj3260675

Shiokawa D., 1997, Arch. Biochem. Biophys., 346, 15, 10.1006/abbi.1997.0275

Shiokawa D., 1998, Biochem. J., 332, 713, 10.1042/bj3320713

Shiokawa D., 1998, Biochem. Biophys. Res. Comm., 247, 864, 10.1006/bbrc.1998.8839

Shiokawa D., 1998, Apoptosis, 3, 85, 10.1023/A:1009692807692

Torriglia A., 1995, J. Biol. Chem., 270, 579, 10.1074/jbc.270.48.28579

Torriglia A., 1997, Biochimie, 79, 435, 10.1016/S0300-9084(97)86153-6

Torriglia A., 1998, Inbitor. Mol. Cell Biol., 18, 3612, 10.1128/MCB.18.6.3612

Torriglia A., 1999, Cell Death Diff., 6, 234, 10.1038/sj.cdd.4400486

Ucker D.S., 1992, Mol. Cell Biol., 12, 3060, 10.1128/MCB.12.7.3060

Urbano A., 1998, J. Biol. Chem., 273, 820, 10.1074/jbc.273.52.34820

Walisser J.A., 1999, Exp. Cell Res., 251, 401, 10.1006/excr.1999.4589

Walker P.R., 1997, Biochem. Cell Biol., 75, 287, 10.1139/o97-053

Wang C.C., 1998, J. Biol. Chem., 273, 192

Wiberg J.S., 1958, Arch. Biochem. Biophys., 73, 337, 10.1016/0003-9861(58)90280-7

Wolf B.B., 1999, J. Biol. Chem., 274, 049

Worrall A.F., 1990, J. Biol. Chem., 265, 889, 10.1016/S0021-9258(18)45822-X

Wright S.C., 1994, J. Exp. Med., 180, 2113, 10.1084/jem.180.6.2113

Wright S.C., 1998, Biochem. Biophys. Res. Comm., 245, 797, 10.1006/bbrc.1998.8508

Wyllie A.H., 1980, Nature (London), 284, 555, 10.1038/284555a0

Yasuda T., 1992, Biochim. Biophys. Acta, 1119, 185, 10.1016/0167-4838(92)90390-Y

Yasuda T., 1998, J. Biol. Chem., 273, 2610, 10.1074/jbc.273.5.2610

Yasuda T., 1998, Ann. Hum. Genet., 62, 299, 10.1046/j.1469-1809.1998.6240299.x

Zhang J., 1998, Proc. Natl. Acad. Sci. U.S.A., 95, 480

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Biochemistry and Cell Biology

Tập 78 Số 4

405-414

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