Se Chan Kim, Alexander Ghanem, Heidi Stapel, Klaus Tiemann, Pascal Knuefermann, Andreas Hoeft, Rainer Meyer, Christian Grohé, Anne A Knowlton, Georg Baumgarten
AbstractBackgoundIt has been reported that Toll-like receptor 4 (TLR4) deficiency reduces infarct size after myocardial ischemia/reperfusion (MI/R). However, measurement of MI/R injury was limited and did not include cardiac function. In a chronic closed-chest model we as...... hiện toàn bộ
Yajun Liu, Lian-Bi Chen, Xiaoqun Xu, Éric Vicaut, R. Sercombe
AbstractBackgroundA major endogenous protective mechanism in many organs against ischemia/reperfusion (I/R) injury is ischemic preconditioning (IPC). By moderately uncoupling the mitochondrial respiratory chain and decreasing production of reactive oxygen species (ROS), IPC reduces apoptosis in...... hiện toàn bộ
Tuuli Lahti, Sami Leppämäki, Jouko Lönnqvist, Timo Partonen
AbstractBackgroundThe aim of this study was to analyze the effects of transition out of and into daylight saving time on the rest-activity cycles and sleep. Rest-activity cycles of nine healthy participants aged 20 to 40 years were measured around transitions out of and into daylight saving tim...... hiện toàn bộ
Sergio A. Gradilone, Pamela S. Tietz, Patrick L. Splinter, Raúl A. Marinelli, Nicholas F. LaRusso
AbstractBackgroundRecent data suggest that canalicular bile secretion involves selective expression and coordinated regulation of aquaporins (AQPs), a family of water channels proteins. In order to further characterize the role of AQPs in this process, an in vitro cel...... hiện toàn bộ
Jussi T. Koivumäki, Tapani Korhonen, Jouni Takalo, Matti Weckström, Pasi Tavi
AbstractBackgroundThe cardiomyocyte is a prime example of inherently complex biological system with inter- and cross-connected feedback loops in signalling, forming the basic properties of intracellular homeostasis. Functional properties of cells and tissues have been studied e.g. with powerful...... hiện toàn bộ