Se Chan Kim, Alexander Ghanem, Heidi Stapel, Klaus Tiemann, Pascal Knuefermann, Andreas Hoeft, Rainer Meyer, Christian Grohé, Anne A Knowlton, Georg Baumgarten
Abstract Backgound It has been reported that Toll-like receptor 4 (TLR4)
deficiency reduces infarct size after myocardial ischemia/reperfusion (MI/R).
However, measurement of MI/R injury was limited and did not include cardiac
function. In a chronic closed-chest model we assessed whether cardiac function
is preserved in TLR4-deficient mice (C3H/HeJ) following MI/R, and whether
myocardial and syste... hiện toàn bộ
Yajun Liu, Lian-Bi Chen, Xiaoqun Xu, Éric Vicaut, R. Sercombe
Abstract Background A major endogenous protective mechanism in many organs
against ischemia/reperfusion (I/R) injury is ischemic preconditioning (IPC). By
moderately uncoupling the mitochondrial respiratory chain and decreasing
production of reactive oxygen species (ROS), IPC reduces apoptosis induced by
I/R by reducing cytochrome c release from the mitochondria. One element believed
to contribute... hiện toàn bộ
Tuuli Lahti, Sami Leppämäki, Jouko Lönnqvist, Timo Partonen
Abstract Background The aim of this study was to analyze the effects of
transition out of and into daylight saving time on the rest-activity cycles and
sleep. Rest-activity cycles of nine healthy participants aged 20 to 40 years
were measured around transitions out of and into daylight saving time on fall
2005 and spring 2006 respectively. Rest-activity cycles were measured using
wrist-worn accele... hiện toàn bộ
Sergio A. Gradilone, Pamela S. Tietz, Patrick L. Splinter, Raúl A. Marinelli, Nicholas F. LaRusso
Abstract Background Recent data suggest that canalicular bile secretion involves
selective expression and coordinated regulation of aquaporins (AQPs), a family
of water channels proteins. In order to further characterize the role of AQPs in
this process, an in vitro cell system with retained polarity and expression of
AQPs and relevant solute transporters involved in bile formation is highly
desir... hiện toàn bộ
Jussi T. Koivumäki, Tapani Korhonen, Jouni Takalo, Matti Weckström, Pasi Tavi
Abstract Background The cardiomyocyte is a prime example of inherently complex
biological system with inter- and cross-connected feedback loops in signalling,
forming the basic properties of intracellular homeostasis. Functional properties
of cells and tissues have been studied e.g. with powerful tools of genetic
engineering, combined with extensive experimentation. While this approach
provides ac... hiện toàn bộ