BMC Physiology
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Subcellular dissemination of prothymosin alpha at normal physiology: immunohistochemical vis-a-vis western blotting perspective
BMC Physiology - Tập 16 - Trang 1-13 - 2016
The cell type, cell status and specific localization of Prothymosin α (PTMA) within cells seemingly determine its function. PTMA undergoes 2 types of protease proteolytic modifications that are useful in elucidating its interactions with other molecules; a factor that typifies its roles. Preferably a nuclear protein, PTMA has been shown to function in the cytoplasm and extracellularly with much ev......
CaMKII content affects contractile, but not mitochondrial, characteristics in regenerating skeletal muscle
BMC Physiology - Tập 14 - Trang 1-16 - 2014
The multi-meric calcium/calmodulin-dependent protein kinase II (CaMKII) is the main CaMK in skeletal muscle and its expression increases with endurance training. CaMK family members are implicated in contraction-induced regulation of calcium handling, fast myosin type IIA expression and mitochondrial biogenesis. The objective of this study was to investigate the role of an increased CaMKII content......
An extensive phenotypic characterization of the hTNFα transgenic mice
BMC Physiology - Tập 7 - Trang 1-16 - 2007
Tumor necrosis factor alpha (TNFα) is implicated in a wide variety of pathological and physiological processes, including chronic inflammatory conditions, coronary artery disease, diabetes, obesity, and cachexia. Transgenic mice expressing human TNFα (hTNFα) have previously been described as a model for progressive rheumatoid arthritis. In this report, we describe extensive characterization of an ......
Điện tâm đồ bình thường ở cừu non trong giai đoạn sơ sinh và sự tiến triển của nó Dịch bởi AI
BMC Physiology - Tập 16 - Trang 1-12 - 2016
Chuyên ngành tim mạch thú y, đặc biệt là điện tâm đồ, đã có những tiến bộ lớn cho tất cả các loài động vật. Do đó, số lượng loài cừu được sử dụng làm động vật thí nghiệm đã tăng lên đến nay. Một số ít nghiên cứu đã được công bố về điện tâm đồ hệ thống ở cừu, đặc biệt liên quan đến sinh lý và sơ sinh của cừu non. Nghiên cứu này nhằm tiêu chuẩn hóa các giá trị của sóng, phức hợp và khoảng thời gian ......
#tim mạch thú y #điện tâm đồ #cừu non #sinh lý #sơ sinh #nhịp tim #khoảng thời gian khí quản
Coral bleaching under thermal stress: putative involvement of host/symbiont recognition mechanisms
BMC Physiology - Tập 9 - Trang 1-16 - 2009
Coral bleaching can be defined as the loss of symbiotic zooxanthellae and/or their photosynthetic pigments from their cnidarian host. This major disturbance of reef ecosystems is principally induced by increases in water temperature. Since the beginning of the 1980s and the onset of global climate change, this phenomenon has been occurring at increasing rates and scales, and with increasing severi......
Dual role of nNOS in ischemic injury and preconditioning
BMC Physiology - Tập 10 - Trang 1-8 - 2010
Nitric oxide (NO) is cardioprotective and a mediator of ischemic preconditioning (IP). Endothelial nitric oxide synthase (eNOS) is protective against myocardial ischemic injury and a component of IP but the role and location of neuronal nitric oxide synthase (nNOS) remains unclear. Therefore, the aims of these studies were to: (i) investigate the role of nNOS in ischemia/reoxygenation-induced inju......
Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature
BMC Physiology - Tập 5 - Trang 1-18 - 2005
Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined. We examined the localization of each of the KATP channel subunits in the mouse and rat heart. Immunohistochemistry of cardiac cryosections demonstrate Kir6.1 protein to be expressed in ventricular myocytes, as well as ......
Short-term pacing in the mouse alters cardiac expression of connexin43
BMC Physiology - Tập 8 - Trang 1-12 - 2008
Cardiac insults such as ischemia, infarction, hypertrophy and dilatation are often accompanied by altered abundance and/or localization of the connexin43 gap junction protein, which may predispose towards arrhythmic complications. Models of chronic dyssynchronous cardiac activation have also been shown to result in redistribution of connexin43 in cardiomyocytes. We hypothesized that alterations in......
A novel method for the evaluation of proximal tubule epithelial cellular necrosis in the intact rat kidney using ethidium homodimer
BMC Physiology - Tập 7 - Trang 1-14 - 2007
Ethidium homodimer is a cell-membrane impermeant nuclear fluorochrome that has been widely used to identify necrotic cells in culture. Here, we describe a novel technique for evaluating necrosis of epithelial cells in the proximal tubule that involves perfusing ethidium homodimer through the intact rat kidney. As a positive control for inducing necrosis, rats were treated with 3.5, 1.75, 0.87 and ......
Exercise training improves relaxation response and SOD-1 expression in aortic and mesenteric rings from high caloric diet-fed rats
BMC Physiology - Tập 8 - Trang 1-8 - 2008
Obesity has been associated with a variety of disease such as type II diabetes mellitus, arterial hypertension and atherosclerosis. Evidences have shown that exercise training promotes beneficial effects on these disorders, but the underlying mechanisms are not fully understood. The aim of this study was to investigate whether physical preconditioning prevents the deleterious effect of high calori......
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