BMC Genomic Data
SCOPUS (2021-2025)SCIE-ISI
2730-6844
Cơ quản chủ quản: BMC , BioMed Central Ltd.
Lĩnh vực:
GeneticsHealth Informatics
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Các bài báo tiêu biểu
Perspective on the combined use of an independent transgenic sexing and a multifactorial reproductive sterility system to avoid resistance development against transgenic Sterile Insect Technique approaches
Tập 15 Số S2 - 2014
Abstract Background The Sterile Insect Technique (SIT) is an accepted
species-specific genetic control approach that acts as an insect birth control
measure, which can be improved by biotechnological engineering to facilitate its
use and widen its applicability. First transgenic insects carrying a single
killing system have already been released in small scale trials. However, to
evade resistance ...
Australian endemic pest tephritids: genetic, molecular and microbial tools for improved Sterile Insect Technique
Tập 15 Số S2 - 2014
AbstractAmong Australian endemic tephritid fruit flies, the sibling
speciesBactrocera tryoniandBactrocera neohumeralishave been serious
horticultural pests since the introduction of horticulture in the nineteenth
century. More recently,Bactrocera jarvisihas also been declared a pest in
northern Australia. After several decades of genetic research there is now a
range of classical and molecular gen...
Genome-wide bioinformatics analysis of Cellulose Synthase gene family in common bean (Phaseolus vulgaris L.) and the expression in the pod development
Tập 23 Số 1 - 2022
Abstract Background CesA and Csl gene families, which belong to the cellulose
synthase gene superfamily, plays an important role in the biosynthesis of the
plant cell wall. Although researchers have investigated this gene superfamily in
several model plants, to date, no comprehensive analysis has been conducted in
the common bean. Results In this study, we identified 39 putative cellulose
synthase...
Re-wiring and gene expression changes of AC025034.1 and ATP2B1 play complex roles in early-to-late breast cancer progression
- 2022
Abstract Background Elucidating the dynamic topological changes across different
stages of breast cancer, called stage re-wiring, could lead to identifying key
latent regulatory signatures involved in cancer progression. Such dynamic
regulators and their functions are mostly unknown. Here, we reconstructed
differential co-expression networks for four stages of breast cancer to assess
the dynamic p...
Transcriptome analysis to identify the downstream genes of androgen receptor in dermal papilla cells
Tập 23 - Trang 1-10 - 2022
Testosterone signaling mediates various diseases, such as androgenetic alopecia
and prostate cancer. Testosterone signaling is mediated by the androgen receptor
(AR). In this study, we fortuitously found that primary and immortalized dermal
papilla cells suppressed AR expression, although dermal papilla cells express AR
in vivo. To analyze the AR signaling pathway, we exogenously introduced the AR...
Deep whole-genome resequencing sheds light on the distribution and effect of amphioxus SNPs
- 2022
Abstract Background Amphioxus is a model organism for vertebrate evolutionary
research. The significant contrast between morphological phenotypic similarity
and high-level genetic polymorphism among amphioxus populations has aroused
scientists' attention. Here we resequenced 21 amphioxus genomes to over 100X
depth and mapped them to a haploid reference. Results More than 11.5 million
common SNPs w...
Morphological and microsatellite DNA diversity of Djallonké sheep in Guinea-Bissau
- 2022
AbstractBackgroundThe present study aimed at characterizing the Djallonké Sheep
(DS), the only local sheep breed raised in Guinea-Bissau. A total of 200 animals
were sampled from four regions (Bafatá, Gabú, Oio and Cacheu) and described
using 7 visual criteria and 8 measurements. These parameters have been studied
by principal components analysis. The genetic diversity and population structure
of ...
Transcriptome signature of miRNA-26b KO mouse model suggests novel targets
Tập 22 Số 1 - 2021
Abstract Background MicroRNAs (miRNAs) are short (20–24 nt) non-coding RNAs that
are involved in post-transcriptional regulation of gene expression in
multicellular organisms by affecting both the stability and translation of
mRNAs. One of the miRNAs that has been shown to play a role in various
pathologies like cancer, neurological disorders and cardiovascular diseases is
miRNA-26b. However, thes...
Identification of prognostic stemness biomarkers in colon adenocarcinoma drug resistance
Tập 23 Số 1
Abstract Background Colon adenocarcinoma (COAD) is one of the leading causes of
death worldwide. Cancer stem cells (CSCs) are vital for COAD chemoresistance and
recurrence, however little is known about stem cell-related biomarkers in drug
resistance and COAD prognosis prediction. Methods To uncover the roles of CSC in
COAD tumorigenesis, chemoresistance, and prognosis, we retrieved COAD patients’...
A statistical measure for the skewness of X chromosome inactivation for quantitative traits and its application to the MCTFR data
- 2021
Abstract Background X chromosome inactivation (XCI) is that one of two
chromosomes in mammalian females is silenced during early development of
embryos. There has been a statistical measure for the degree of the skewness of
XCI for qualitative traits. However, no method is available for such task at
quantitative trait loci. Results In this article, we extend the existing
statistical measure for th...