BMC Genomic Data

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Bioinformatics analysis reveals the potential target of rosiglitazone as an antiangiogenic agent for breast cancer therapy
BMC Genomic Data - Tập 23 - Trang 1-17 - 2022
Adam Hermawan, Herwandhani Putri
Several studies have demonstrated the antitumor activity of rosiglitazone (RGZ) in cancer cells, including breast cancer cells. However, the molecular targets of RGZ in the inhibition of angiogenesis in breast cancer cells remain unclear. This study aimed to explore the potential targets of RGZ in inhibiting breast cancer angiogenesis using bioinformatics-based analysis. Venn diagram analysis reve...... hiện toàn bộ
Multiple datasets to explore the molecular mechanism of sepsis
BMC Genomic Data - Tập 23 Số 1 - Trang 1-13 - 2022
Lin, Shuang, Luo, Bin, Ma, Junqi
This study aimed to identify potential biomarkers, by means of bioinformatics, affecting the occurrence and development of septic shock. Download GSE131761 septic shock data set from NCBI geo database, including 33 control samples and 81 septic shock samples. GSE131761 and sequencing data were used to identify and analyze differentially expressed genes in septic shock patients and normal subjects....... hiện toàn bộ
Phân tích biểu hiện gen của tuyến tùng cho thấy sự điều hòa khác biệt của lncRNA và mRNA liên quan đến năng suất trong cừu STH với hai kiểu gen FecB Dịch bởi AI
BMC Genomic Data - Tập 22 - Trang 1-17 - 2021
Chunyan Li, Xiaoyun He, Zijun Zhang, Chunhuan Ren, Mingxing Chu
RNA không mã hóa dài (lncRNA) đã được xác định là yếu tố điều chỉnh quan trọng trong trục hạ đồi-tuyến yên-buồng trứng liên quan đến năng suất sinh sản ở cừu. Tuy nhiên, rất ít thông tin về mô hình biểu hiện và vai trò tiềm năng của chúng trong tuyến tùng của cừu được biết đến. Ở đây, RNA-Seq đã được sử dụng để phát hiện mô hình biểu hiện transcriptome trong tuyến tùng giữa pha nang trứng (FP) và ...... hiện toàn bộ
#lncRNA #mRNA #tuyến tùng #cừu STH #năng suất sinh sản #RNA-Seq
Polyploidization of Indotyphlops braminus: evidence from isoform-sequencing
BMC Genomic Data - - 2024
Fei Zhu, Jing Lu, Ke Sun, Cao Deng, Yu Xu
Indotyphlops braminus, the only known triploid parthenogenetic snake, is a compelling species for revealing the mechanism of polyploid emergence in vertebrates. In this study, we applied PacBio isoform sequencing technology to generate the first full-length transcriptome of I. braminus, aiming to improve the understanding of the molecular characteristics of this species. A total of 51,849 nonredun...... hiện toàn bộ
Mapping phenotypic performance and novel SNPs for cold tolerance in tomato (Solanum lycopersicum) genotypes through GWAS and population genetics
BMC Genomic Data -
Labiba Riyaz Shah, Nazeer Ahmed, Khursheed Hussain, Sheikh Mansoor, Tamana Khan, İmran Khan, Sumati Narayan, Baseerat Afroza, Imtiyaz Murtaza, Asif B. Shikari, Basharat Bhat, Khalid Z. Masoodi
AbstractThe cold stress susceptibility of tomato (Solanum lycopersicum) curtails its cultivation, with significant impact in temperate regions and on cropping seasons. To unravel genomic regions responsible for cold stress resilience, a diverse set of fifty genotypes encompassing cultivated, wild species, and landraces were genotyped usin...... hiện toàn bộ
Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure
BMC Genomic Data - Tập 23 Số 1 - Trang 1-18 - 2022
Osman, Noha, Shawky, Abd-El-Monsif, Brylinski, Michal
Numerous genome-wide association studies (GWAS) conducted to date revealed genetic variants associated with various diseases, including breast and prostate cancers. Despite the availability of these large-scale data, relatively few variants have been functionally characterized, mainly because the majority of single-nucleotide polymorphisms (SNPs) map to the non-coding regions of the human genome. ...... hiện toàn bộ
Comprehensive analysis of m6A regulators and relationship with tumor microenvironment, immunotherapy strategies in colorectal adenocarcinoma
BMC Genomic Data - Tập 24 - Trang 1-13 - 2023
Jian Ji, Shichao Liu, Yongyuan Liang, Guixi Zheng
The N6-methyladenosine (m6A) RNA modification is the most prevalent and abundant type found in eukaryotic cells. It plays a crucial role in the initiation and progression of cancers. In this study, we aimed to comprehensively investigate the landscape of m6A regulators and their association with tumor microenvironment (TME), immunotherapeutic strategies in colon adenocarcinoma (COAD). The differen...... hiện toàn bộ
In depth analysis of Cyprus-specific mutations of SARS-CoV-2 strains using computational approaches
BMC Genomic Data - Tập 22 - Trang 1-15 - 2021
Anastasis Oulas, Jan Richter, Maria Zanti, Marios Tomazou, Kyriaki Michailidou, Kyproula Christodoulou, Christina Christodoulou, George M. Spyrou
This study aims to characterize SARS-CoV-2 mutations which are primarily prevalent in the Cypriot population. Moreover, using computational approaches, we assess whether these mutations are associated with changes in viral virulence. We utilize genetic data from 144 sequences of SARS-CoV-2 strains from the Cypriot population obtained between March 2020 and January 2021, as well as all data availab...... hiện toàn bộ
Revised eutherian gene collections
BMC Genomic Data - Tập 23 - Trang 1-4 - 2022
Marko Premzl
The most recent research projects in scientific field of eutherian comparative genomics included intentions to sequence every extant eutherian species genome in foreseeable future, so that future revisions and updates of eutherian gene data sets were expected. Using 35 public eutherian reference genomic sequence assemblies and free available software, the eutherian comparative genomic analysis pro...... hiện toàn bộ
Morphological characterization and genetic diversity analysis of Tunisian durum wheat (Triticum turgidum var. durum) accessions
BMC Genomic Data - Tập 22 - Trang 1-17 - 2021
Maroua Ouaja, Bochra A. Bahri, Lamia Aouini, Sahbi Ferjaoui, Maher Medini, Thierry C. Marcel, Sonia Hamza
Tunisia is considered a secondary center of diversification of durum wheat and has a large number of abandoned old local landraces. An accurate investigation and characterization of the morphological and genetic features of these landraces would allow their rehabilitation and utilization in wheat breeding programs. Here, we investigated a diverse collection of 304 local accessions of durum wheat c...... hiện toàn bộ
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