BMC Genomic Data
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Bioinformatics analysis reveals the potential target of rosiglitazone as an antiangiogenic agent for breast cancer therapy
BMC Genomic Data - Tập 23 - Trang 1-17 - 2022
Several studies have demonstrated the antitumor activity of rosiglitazone (RGZ) in cancer cells, including breast cancer cells. However, the molecular targets of RGZ in the inhibition of angiogenesis in breast cancer cells remain unclear. This study aimed to explore the potential targets of RGZ in inhibiting breast cancer angiogenesis using bioinformatics-based analysis. Venn diagram analysis reve......
Phân tích biểu hiện gen của tuyến tùng cho thấy sự điều hòa khác biệt của lncRNA và mRNA liên quan đến năng suất trong cừu STH với hai kiểu gen FecB Dịch bởi AI
BMC Genomic Data - Tập 22 - Trang 1-17 - 2021
RNA không mã hóa dài (lncRNA) đã được xác định là yếu tố điều chỉnh quan trọng trong trục hạ đồi-tuyến yên-buồng trứng liên quan đến năng suất sinh sản ở cừu. Tuy nhiên, rất ít thông tin về mô hình biểu hiện và vai trò tiềm năng của chúng trong tuyến tùng của cừu được biết đến. Ở đây, RNA-Seq đã được sử dụng để phát hiện mô hình biểu hiện transcriptome trong tuyến tùng giữa pha nang trứng (FP) và ......
#lncRNA #mRNA #tuyến tùng #cừu STH #năng suất sinh sản #RNA-Seq
Mapping phenotypic performance and novel SNPs for cold tolerance in tomato (Solanum lycopersicum) genotypes through GWAS and population geneticsAbstract The cold stress susceptibility of tomato (Solanum lycopersicum ) curtails its cultivation, with significant impact in temperate regions and on cropping seasons. To unravel genomic regions responsible for cold stress resilience, a diverse set of fifty genotypes encompassing cultivated, wild species, and landraces were genotyped usin... ...
BMC Genomic Data -
Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure
BMC Genomic Data - Tập 23 Số 1 - Trang 1-18 - 2022
Numerous genome-wide association studies (GWAS) conducted to date revealed genetic variants associated with various diseases, including breast and prostate cancers. Despite the availability of these large-scale data, relatively few variants have been functionally characterized, mainly because the majority of single-nucleotide polymorphisms (SNPs) map to the non-coding regions of the human genome. ......
Whole-genome sequence of Macaca fascicularis: liver tissue
BMC Genomic Data - Tập 24 - Trang 1-3 - 2023
Thrombocytopenia is a condition that causes a low amount of blood platelets. Platelets are blood cells that play an essential role in blood coagulation. Therefore, thrombocytopenia can put the patient at risk for mild to severe bleeding. Thrombocytopenia is caused by a decrease in platelet production in the bone marrow or by a drug or immune system problem when production is normal. In particular,......
Assessing whole-exome sequencing data from undiagnosed Brazilian patients to improve the diagnostic yield of inborn errors of immunity
BMC Genomic Data - Tập 24 - Trang 1-5 - 2023
Inborn error of immunity (IEI) comprises a broad group of inherited immunological disorders that usually display an overlap in many clinical manifestations challenging their diagnosis. The identification of disease-causing variants from whole-exome sequencing (WES) data comprises the gold-standard approach to ascertain IEI diagnosis. The efforts to increase the availability of clinically relevant ......
Identification and genetic characterization of a minor norovirus genotype, GIX.1[GII.P15], from China
BMC Genomic Data - Tập 23 - Trang 1-11 - 2022
Human noroviruses, single-stranded RNA viruses in the family Caliciviridae, are a leading cause of nonbacterial acute gastroenteritis in people of all ages worldwide. Despite three decades of genomic sequencing and epidemiological norovirus studies, full-length genome analyses of the non-epidemic or minor norovirus genotypes are rare and genomic regions other than ORF2 and 3′-end of ORF1 have been......
On the importance of metadata when sharing and opening data
BMC Genomic Data - Tập 23 - Trang 1-3 - 2022
While data sharing increases, most open data are difficult to re-use or to identify due to the lack of related metada. In this editorial, I discussed about the importance of those metadata in the context of genomic, and why they are mandatory to ensure the success of data sharing.
Analysis of transcriptomic data sets supports the role of IL-6 in NETosis and immunothrombosis in severe COVID-19
BMC Genomic Data - Tập 22 - Trang 1-14 - 2021
There is an urgent need to understand the key events driving pathogenesis of severe COVID-19 disease, so that precise treatment can be instituted. In this respect NETosis is gaining increased attention in the scientific community, as an important pathological process contributing to mortality. We sought to test if indeed there exists robust evidence of NETosis in multiple transcriptomic data sets ......
High-quality genome resource of Lasiodiplodia pseudotheobromae associated with die-back on Eucalyptus trees
BMC Genomic Data - Tập 25 - Trang 1-4 - 2024
Lasiodiplodia pseudotheobromae is an important fungal pathogen associated with die-back, canker and shoot blight in many plant hosts with a wide geographic distribution. The aim of our study was to provide high-quality genome assemblies and sequence annotation resources of L. pseudotheobromae, to facilitate future studies on the systematics, population genetics and genomics of the fungal pathogen ......
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