BMC Genomic Data
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Bioinformatics analysis reveals the potential target of rosiglitazone as an antiangiogenic agent for breast cancer therapy
BMC Genomic Data - Tập 23 - Trang 1-17 - 2022
Several studies have demonstrated the antitumor activity of rosiglitazone (RGZ) in cancer cells, including breast cancer cells. However, the molecular targets of RGZ in the inhibition of angiogenesis in breast cancer cells remain unclear. This study aimed to explore the potential targets of RGZ in inhibiting breast cancer angiogenesis using bioinformatics-based analysis. Venn diagram analysis reve......
Phân tích biểu hiện gen của tuyến tùng cho thấy sự điều hòa khác biệt của lncRNA và mRNA liên quan đến năng suất trong cừu STH với hai kiểu gen FecB Dịch bởi AI
BMC Genomic Data - Tập 22 - Trang 1-17 - 2021
RNA không mã hóa dài (lncRNA) đã được xác định là yếu tố điều chỉnh quan trọng trong trục hạ đồi-tuyến yên-buồng trứng liên quan đến năng suất sinh sản ở cừu. Tuy nhiên, rất ít thông tin về mô hình biểu hiện và vai trò tiềm năng của chúng trong tuyến tùng của cừu được biết đến. Ở đây, RNA-Seq đã được sử dụng để phát hiện mô hình biểu hiện transcriptome trong tuyến tùng giữa pha nang trứng (FP) và ......
#lncRNA #mRNA #tuyến tùng #cừu STH #năng suất sinh sản #RNA-Seq
Polyploidization of Indotyphlops braminus: evidence from isoform-sequencing
BMC Genomic Data - - 2024
Indotyphlops braminus, the only known triploid parthenogenetic snake, is a compelling species for revealing the mechanism of polyploid emergence in vertebrates. In this study, we applied PacBio isoform sequencing technology to generate the first full-length transcriptome of I. braminus, aiming to improve the understanding of the molecular characteristics of this species. A total of 51,849 nonredun......
Mapping phenotypic performance and novel SNPs for cold tolerance in tomato (Solanum lycopersicum) genotypes through GWAS and population geneticsAbstract The cold stress susceptibility of tomato (Solanum lycopersicum ) curtails its cultivation, with significant impact in temperate regions and on cropping seasons. To unravel genomic regions responsible for cold stress resilience, a diverse set of fifty genotypes encompassing cultivated, wild species, and landraces were genotyped usin... ...
BMC Genomic Data -
Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure
BMC Genomic Data - Tập 23 Số 1 - Trang 1-18 - 2022
Numerous genome-wide association studies (GWAS) conducted to date revealed genetic variants associated with various diseases, including breast and prostate cancers. Despite the availability of these large-scale data, relatively few variants have been functionally characterized, mainly because the majority of single-nucleotide polymorphisms (SNPs) map to the non-coding regions of the human genome. ......
Comprehensive analysis of m6A regulators and relationship with tumor microenvironment, immunotherapy strategies in colorectal adenocarcinoma
BMC Genomic Data - Tập 24 - Trang 1-13 - 2023
The N6-methyladenosine (m6A) RNA modification is the most prevalent and abundant type found in eukaryotic cells. It plays a crucial role in the initiation and progression of cancers. In this study, we aimed to comprehensively investigate the landscape of m6A regulators and their association with tumor microenvironment (TME), immunotherapeutic strategies in colon adenocarcinoma (COAD). The differen......
Revised eutherian gene collections
BMC Genomic Data - Tập 23 - Trang 1-4 - 2022
The most recent research projects in scientific field of eutherian comparative genomics included intentions to sequence every extant eutherian species genome in foreseeable future, so that future revisions and updates of eutherian gene data sets were expected. Using 35 public eutherian reference genomic sequence assemblies and free available software, the eutherian comparative genomic analysis pro......
Long-term dynamic compression enhancement TGF-β3-induced chondrogenesis in bovine stem cells: a gene expression analysis
BMC Genomic Data - Tập 22 - Trang 1-12 - 2021
Bioengineering has demonstrated the potential of utilising mesenchymal stem cells (MSCs), growth factors, and mechanical stimuli to treat cartilage defects. However, the underlying genes and pathways are largely unclear. This is the first study on screening and identifying the hub genes involved in mechanically enhanced chondrogenesis and their potential molecular mechanisms. The datasets were dow......
Whole-genome sequence of Macaca fascicularis: liver tissue
BMC Genomic Data - Tập 24 - Trang 1-3 - 2023
Thrombocytopenia is a condition that causes a low amount of blood platelets. Platelets are blood cells that play an essential role in blood coagulation. Therefore, thrombocytopenia can put the patient at risk for mild to severe bleeding. Thrombocytopenia is caused by a decrease in platelet production in the bone marrow or by a drug or immune system problem when production is normal. In particular,......
SARS-CoV-2 and human retroelements: a case for molecular mimicry?
BMC Genomic Data - Tập 23 - Trang 1-9 - 2022
The factors driving the late phase of COVID-19 are still poorly understood. However, autoimmunity is an evolving theme in COVID-19’s pathogenesis. Additionally, deregulation of human retroelements (RE) is found in many viral infections, and has also been reported in COVID-19. Unexpectedly, coronaviruses (CoV) – including SARS-CoV-2 – harbour many RE-identical sequences (up to 35 base pairs), and s......
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