BMC Developmental Biology
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Transgenic and knockout analyses of Masculinizer and doublesex illuminated the unique functions of doublesex in germ cell sexual development of the silkworm, Bombyx mori
BMC Developmental Biology - Tập 20 - Trang 1-15 - 2020
Masculinizer (Masc) plays a pivotal role in male sex determination in the silkworm, Bombyx mori. Masc is required for male-specific splicing of B. mori doublesex (Bmdsx) transcripts. The male isoform of Bmdsx (BmdsxM) induces male differentiation in somatic cells, while females express the female isoform of Bmdsx (BmdsxF), which promotes female differentiation in somatic cells. Our previous findin......
Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish
BMC Developmental Biology - - 2007
Little is known about the control of the development of vertebrate unpaired appendages such as the caudal fin, one of the key morphological specializations of fishes. Recent analysis of lamprey and dogshark median fins suggests the co-option of some molecular mechanisms between paired and median in Chondrichthyes. However, the extent to which the molecular mechanisms patterning paired and median f......
Penetrance of eye defects in mice heterozygous for mutation of Gli3 is enhanced by heterozygous mutation of Pax6
BMC Developmental Biology - Tập 6 - Trang 1-11 - 2006
Knowledge of the consequences of heterozygous mutations of developmentally important genes is important for understanding human genetic disorders. The Gli3 gene encodes a zinc finger transcription factor and homozygous loss-of-function mutations of Gli3 are lethal. Humans heterozygous for mutations in this gene suffer Greig cephalopolysyndactyly or Pallister-Hall syndromes, in which limb defects a......
Isoform-specific functions of Mud/NuMA mediate binucleation of Drosophilamale accessory gland cells
BMC Developmental Biology - - 2014
A highly conserved regulatory element controls hematopoietic expression of GATA-2in zebrafish
BMC Developmental Biology - Tập 7 - Trang 1-13 - 2007
GATA-2 is a transcription factor required for hematopoietic stem cell survival as well as for neuronal development in vertebrates. It has been shown that specific expression of GATA-2 in blood progenitor cells requires distal cis-acting regulatory elements. Identification and characterization of these elements should help elucidating transcription regulatory mechanisms of GATA-2 expression in hema......
Identification of genes differentially expressed during larval molting and metamorphosis of Helicoverpa armigera
BMC Developmental Biology - Tập 7 - Trang 1-16 - 2007
Larval molting and metamorphosis are important physiological processes in the life cycle of the holometabolous insect. We used suppression subtractive hybridization (SSH) to identify genes differentially expressed during larval molting and metamorphosis. We performed SSH between tissues from a variety of developmental stages, including molting 5th and feeding 6th instar larvae, metamorphically com......
Differences among families in craniofacial shape at early life-stages of Arctic charr (Salvelinus alpinus)
BMC Developmental Biology - Tập 20 - Trang 1-15 - 2020
Organismal fitness can be determined at early life-stages, but phenotypic variation at early life-stages is rarely considered in studies on evolutionary diversification. The trophic apparatus has been shown to contribute to sympatric resource-mediated divergence in several taxa. However, processes underlying diversification in trophic traits are poorly understood. Using phenotypically variable Ice......
Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes
BMC Developmental Biology - Tập 8 - Trang 1-14 - 2008
The maternal contribution of transcripts and proteins supplied to the zygote is crucial for the progression from a gametic to an embryonic control of preimplantation development. Here we compared the transcriptional profiles of two types of mouse MII oocytes, one which is developmentally competent (MIISN oocyte), the other that ceases development at the 2-cell stage (MIINSN oocyte), with the aim o......
The lin-35/ Rb and RNAi pathways cooperate to regulate a key cell cycle transition in C. elegans
BMC Developmental Biology - Tập 7 Số 1 - Trang 1-16 - 2007
The Retinoblastoma gene product (Rb) has been shown to regulate the transcription of key genes involved in cell growth and proliferation. Consistent with this, mutations in Rb are associated with numerous types of cancer making it a critical tumour suppressor gene. Its function is conferred through a large multiprotein complex that exhibits a dual function in both activation and repression of gene......
Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo
BMC Developmental Biology - Tập 5 - Trang 1-12 - 2005
Huntingtin, the HD gene encoded protein mutated by polyglutamine expansion in Huntington's disease, is required in extraembryonic tissues for proper gastrulation, implicating its activities in nutrition or patterning of the developing embryo. To test these possibilities, we have used whole mount in situ hybridization to examine embryonic patterning and morphogenesis in homozygous Hdhex4/5huntingti......
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