BMC Developmental Biology

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Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish
BMC Developmental Biology - - 2007
Yavor Hadzhiev, Zsolt Lele, Simone Schindler, Stephen W Wilson, Per Ahlberg, Uwe Strähle, Ferenc Müller
Little is known about the control of the development of vertebrate unpaired appendages such as the caudal fin, one of the key morphological specializations of fishes. Recent analysis of lamprey and dogshark median fins suggests the co-option of some molecular mechanisms between paired and median in Chondrichthyes. However, the extent to which the molecular mechanisms patterning paired and median f...... hiện toàn bộ
The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation
BMC Developmental Biology - Tập 8 Số 1 - 2008
Veronica Ulici, Katie D. Hoenselaar, J. R. Gillespie, Frank Beier
Abstract Background The majority of our bones develop through the process of endochondral ossification that involves chondrocyte proliferation and hypertrophic differentiation in the cartilage growth plate. A large number of growth factors and hormones have been implicated in the regulation of gr...... hiện toàn bộ
Generation of diverse neuronal subtypes in cloned populations of stem-like cells
BMC Developmental Biology - Tập 8 - Trang 1-18 - 2008
Balázs V Varga, Nóra Hádinger, Elen Gócza, Vered Dulberg, Kornél Demeter, Emília Madarász, Balázs Herberth
The central nervous tissue contains diverse subtypes of neurons with characteristic morphological and physiological features and different neurotransmitter phenotypes. The generation of neurons with defined neurotransmitter phenotypes seems to be governed by factors differently expressed along the anterior-posterior and dorsal-ventral body axes. The mechanisms of the cell-type determination, howev...... hiện toàn bộ
Developmental cues and persistent neurogenic potential within an in vitro neural niche
BMC Developmental Biology -
Chris Pierret, Jason A. Morrison, Peter Rath, Rachel E. Zigler, Laura A. Engel, Corinne L. Fairchild, Huidong Shi, J.A. Maruniak, Mark D. Kirk
Abstract Background Neurogenesis, the production of neural cell-types from neural stem cells (NSCs), occurs during development as well as within select regions of the adult brain. NSCs in the adult subependymal zone (SEZ) exist in a well-categorized niche microenvironment established by surrounding ...... hiện toàn bộ
Notochord-derived hedgehog is essential for tail regeneration in Xenopus tadpole
BMC Developmental Biology - Tập 14 - Trang 1-9 - 2014
Yuka Taniguchi, Kenji Watanabe, Makoto Mochii
Appendage regeneration in amphibians is regulated by the combinatorial actions of signaling molecules. The requirement of molecules secreted from specific tissues is reflected by the observation that the whole process of regeneration can be inhibited if a certain tissue is removed from the amputated stump. Interestingly, urodeles and anurans show different tissue dependencies during tail regenerat...... hiện toàn bộ
Sox7 is dispensable for primitive endoderm differentiation from mouse ES cells
BMC Developmental Biology - Tập 15 - Trang 1-11 - 2015
Masaki Kinoshita, Daisuke Shimosato, Mariko Yamane, Hitoshi Niwa
Primitive endoderm is a cell lineage segregated from the epiblast in the blastocyst and gives rise to parietal and visceral endoderm. Sox7 is a member of the SoxF gene family that is specifically expressed in primitive endoderm in the late blastocyst, although its function in this cell lineage remains unclear. Here we characterize the function of Sox7 in primitive endoderm differentiation using mo...... hiện toàn bộ
Cold-inducible RNA binding protein (CIRP), a novel XTcf-3 specific target gene regulates neural development in Xenopus
BMC Developmental Biology - - 2008
Stephanie van Venrooy, Dagmar Fichtner, Martin Kunz, Doris Wedlich, Dietmar Gradl
Abstract Background As nuclear mediators of wnt/β-catenin signaling, Lef/Tcf transcription factors play important roles in development and disease. Although it is well established, that the four vertebrate Lef/Tcfs have unique functional properties, most studies unite Lef-1, Tcf-1, Tcf-3 and Tcf-...... hiện toàn bộ
The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model
BMC Developmental Biology - - 2015
Renita C. Polk, Péter Gergics, Jeffrey D. Steimle, Huiqing Li, Ivan P. Moskowitz, Sally A. Camper, Roger H. Reeves
Molecular markers to characterize the hermaphroditic reproductive system of the planarian Schmidtea mediterranea
BMC Developmental Biology - - 2011
Tracy Chong, Joel M Stary, Yuying Wang, Phillip A Newmark
The freshwater planarian Schmidtea mediterranea exhibits two distinct reproductive modes. Individuals of the sexual strain are cross-fertilizing hermaphrodites with reproductive organs that develop post-embryonically. By contrast, individuals of the asexual strain reproduce exclusively by transverse fission and fail to develop reproductive organs. These different reproductive strains are associate...... hiện toàn bộ
14-3-3 epsilon prevents G2/M transition of fertilized mouse eggs by binding with CDC25B
BMC Developmental Biology - Tập 14 - Trang 1-13 - 2014
Cheng Cui, Xiuli Ren, Dajun Liu, Xin Deng, Xin Qin, Xiangyu Zhao, Enhua Wang, Bingzhi Yu
The 14-3-3 (YWHA) proteins are highly conserved in higher eukaryotes, participate in various cellular signaling pathways including cell cycle regulation, development and growth. Our previous studies demonstrated that 14-3-3ε (YWHAE) is responsible for maintaining prophase | arrest in mouse oocyte. However, roles of 14-3-3ε in the mitosis of fertilized mouse eggs have remained unclear. Here, we sho...... hiện toàn bộ
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