BMC Developmental Biology
SCOPUS (2001-2021)
1471-213X
Cơ quản chủ quản: BioMed Central Ltd.
Lĩnh vực:
Developmental Biology
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Các bài báo tiêu biểu
Dynamics of muscle fibre growth during postnatal mouse development
- 2010
Abstract Background Postnatal growth in mouse is rapid, with total skeletal
muscle mass increasing several-fold in the first few weeks. Muscle growth can be
achieved by either an increase in muscle fibre number or an increase in the size
of individual myofibres, or a combination of both. Where myofibre hypertrophy
during growth requires the addition of new myonuclei, these are supplied by
muscle s...
Assisted Reproductive Technology affects developmental kinetics, H19 Imprinting Control Region methylation and H19gene expression in individual mouse embryos
Abstract Background In the last few years, an increase in imprinting anomalies
has been reported in children born from Assisted Reproductive Technology (ART).
Various clinical and experimental studies also suggest alterations of embryo
development after ART. Therefore, there is a need for studying early epigenetic
anomalies which could result from ART manipulations, especially on single
embryos. I...
A genome-wide in situhybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain
Tập 5 Số 1 - 2005
AbstractBackgroundIn eukaryotic cells, RNA-binding proteins (RBPs) contribute to
gene expression by regulating the form, abundance, and stability of both coding
and non-coding RNA. In the vertebrate brain, RBPs account for many distinctive
features of RNA processing such as activity-dependent transcript localization
and localized protein synthesis. Several RBPs with activities that are important
f...
Two-color fluorescent in situ hybridization in the embryonic zebrafish brain using differential detection systems
- 2011
Abstract Background Whole-mount in situ hybridization (WISH) is extensively used
to characterize gene expression patterns in developing and adult brain and other
tissues. To obtain an idea whether a novel gene might be involved in
specification of a distinct brain subdivision, nucleus or neuronal lineage, it
is often useful to correlate its expression with that of a known regional or
neuronal mark...
Expression of miR-1, miR-133a, miR-133b and miR-206 increases during development of human skeletal muscle
- 2011
Abstract Background MicroRNAs (miRNAs) are small RNA molecules that
post-transcriptionally regulate gene expression and have been shown to play an
important role during development. miR-1, miR-133a, miR-133b and miR-206 are
expressed in muscle tissue and induced during muscle cell differentiation, a
process that directs myoblasts to differentiate into mature myotubes, which are
organized into myof...
Differential dynamics of histone H3 methylation at positions K4 and K9 in the mouse zygote
Tập 4 Số 1
Validation of reference genes for quantitative RT-PCR studies in porcine oocytes and preimplantation embryos
Tập 7 Số 1 - 2007
Abstract Background In the developing embryo, total RNA abundance fluctuates
caused by functional RNA degradation and zygotic genome activation. These
variations in the transcriptome in early development complicate the choice of
good reference genes for gene expression studies by quantitative real time
polymerase chain reaction. Results In order to identify stably expressed genes
for normalisation...
Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation
Tập 10 Số 1 - 2010
AbstractBackgroundPax2;5;8transcription factors play diverse roles in vertebrate
and invertebrate organogenesis, including the development of the inner ear. Past
research has suggested various cochlear defects and some vestibular defects
inPax2null mice but the details of the cochlear defects and the interaction with
otherPaxfamily members in ear development remain unclear.ResultsWe show
thatPax2;...
Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells
Tập 6 Số 1 - 2006
AbstractBackgroundWe previously identified a set of genes called ECATs (ES
cell-associated transcripts) that are expressed at high levels in mouse ES
cells. Here, we examine the expression and DNA methylation of ECATs in somatic
cells and germ cells.ResultsIn all ECATs examined, the promoter region had low
methylation levels in ES cells, but higher levels in somatic cells. In contrast,
in spite of...