Antiviral Therapy
SCIE-ISI SCOPUS (1996-2025)
2040-2058
1359-6535
Anh Quốc
Cơ quản chủ quản: Sage Publications , SAGE Publications Ltd
Lĩnh vực:
Pharmacology (medical)PharmacologyInfectious Diseases
Các bài báo tiêu biểu
Amantadine-Oseltamivir Combination therapy for H5N1 Influenza Virus Infection in Mice
Tập 12 Số 3 - Trang 363-370 - 2007
Background The clinical management of H5N1 influenza virus infection in humans
remains unclear. Combination chemotherapy with drugs that target different viral
proteins might be more effective than monotherapy. Methods BALB/c mice were
treated by oral gavage for 5 days with amantadine (1.5, 15 or 30 mg/kg/day) and
oseltamivir (1 or 10 mg/kg/day) separately or in combination. Mice were
challenged 2...
Rates of Emergence of HIV Drug Resistance in Resource-Limited Settings: A Systematic Review
Tập 18 Số 1 - Trang 115-123 - 2013
BackgroundThe increasing availability of antiretroviral therapy (ART) has
improved survival and quality of life for many infected with HIV, but can also
engender drug resistance. This review summarizes the available information on
drug resistance in adults in resource-limited settings.MethodsThe online
databases PubMed and Google Scholar, pertinent conference abstracts and
references from relevant...
Comprehensive assessment of 2009 Pandemic Influenza a (H1N1) Virus Drug Susceptibility in vitro
Tập 15 Số 8 - Trang 1151-1159 - 2010
Background Antiviral drugs are an important option for managing infections
caused by influenza viruses. This study assessed the drug susceptibility of 2009
pandemic influenza A (H1N1) viruses collected globally between April 2009 and
January 2010. Methods Virus isolates were tested for adamantane susceptibility,
using pyrosequencing to detect the S31N marker of adamantane resistance in the
M2 prot...
Investigation of Baseline Susceptibility to Protease Inhibitors in HIV-1 Subtypes C, F, G and Crf02_Ag
Tập 11 Số 5 - Trang 581-589 - 2006
Objective To compare baseline susceptibility to protease inhibitors among HIV-1
isolates of subtypes C, F, G and CRF02_AG, and to identify polymorphisms that
determine the differences in susceptibility. Methods A total of 42 samples of
drug-naive patients infected with subtypes G ( n=19), CRF02_AG ( n=10), F ( n=6)
and C ( n=7) were phenotyped and genotyped with the Antivirogram and the ViroSeq
2....
HIV-1 Subtypes and Response to Combination Antiretroviral Therapy in Europe
Tập 11 Số 6 - Trang 707-716 - 2006
Background Combination antiretroviral therapy (cART) may vary in ability to
suppress viral load and increase CD4+ T-cell count in people infected with
different HIV-1 subtypes, possibly due to differences in resistance development.
Antiretroviral drugs have predominantly been developed in Western Europe/North
America on the basis of the most prevalent subtype, B. However, non-B subtypes
are increa...
Mitochondrial (Mt)Dna Changes in Tissue May Not be Reflected by Depletion of Mtdna in Peripheral Blood Mononuclear Cells in HIV-Infected Patients
Tập 11 Số 5 - Trang 601-608 - 2006
Objectives Most data on mitochondrial toxicity have been derived from peripheral
blood mononuclear cells (PBMCs). However, whether mitochondrial DNA (mtDNA)
content in PBMCs reflects the mitochondrial state in tissues remains elusive. We
report herein on mitochondrial toxicity in skeletal muscle in HIV-infected
patients naive to antiretroviral treatment (ART [HIV+ART-naive]; n=10) patients
exposed...
Silymarin for HCV infection
Tập 18 Số 2 - Trang 141-147 - 2013
Silymarin, an extract of milk thistle seeds, and silymarin-derived compounds
have been considered hepatoprotective since the plant was first described in
ancient times. Hepatoprotection is defined as several non-mutually exclusive
biological activities including antiviral, antioxidant, anti-inflammatory and
immunomodulatory functions. Despite clear evidence for silymarin-induced
hepatoprotection i...
High Incidence of Non-B and Recombinant HIV-1 Strains in Newly Diagnosed Patients in Galicia, Spain: Study of Genotypic Resistance
Tập 8 Số 4 - Trang 355-360 - 2003
The objectives of this study are to describe the incidence of non-B and
recombinant HIV-1 strains in newly diagnosed HIV-1 infections in Galicia,
northwest of Spain, during a 2-year period (May 2000 to June 2002), and the
frequency of resistance-associated mutations in reverse transcriptase (RT) and
protease (PR) genes, analysing the polymorphisms more frequently detected in
non-B and recombinant ...
Safety and Efficacy of Once-Daily Nevirapine Dosing: A Multicohort Study
Tập 14 Số 7 - Trang 931-938 - 2009
Background Nevirapine (NVP) is often prescribed once daily in clinical practice
in combination with a once daily nucleoside backbone. We investigated the
relationship of NVP dosing with safety and efficacy. Methods Patients from the
Dutch AIDS Therapy Evaluation in the Netherlands (ATHENA) cohort study, Canadian
HAART Observational Medical Evaluation and Research (HOMER) cohort and Swiss HIV
Cohor...
Liver Triglyceride Content in HIV-1-Infected Patients on Combination Antiretroviral Therapy Studied with 1H-MR Spectroscopy
Tập 12 Số 2 - Trang 195-204 - 2007
Objective To carry out an exploratory evaluation of liver triglyceride content
in HIV-1-infected patients receiving highly active antiretroviral therapy
(HAART) using proton magnetic resonance spectroscopy and to study how both the
treatment itself and the biochemical and physiological variables in which the
treatment causes alterations are related to liver fat content. Methods
Intracellular hepat...