Antiviral Therapy
SCIE-ISI SCOPUS (1996-2023)
2040-2058
1359-6535
Anh Quốc
Cơ quản chủ quản: Sage Publications , SAGE Publications Ltd
Lĩnh vực:
Pharmacology (medical)PharmacologyInfectious Diseases
Các bài báo tiêu biểu
Amantadine-Oseltamivir Combination therapy for H5N1 Influenza Virus Infection in MiceBackground The clinical management of H5N1 influenza virus infection in humans remains unclear. Combination chemotherapy with drugs that target different viral proteins might be more effective than monotherapy. Methods BALB/c mice were treated by oral gavage for 5 days with amantadine (1.5, 15...
Tập 12 Số 3 - Trang 363-370 - 2007
Rates of Emergence of HIV Drug Resistance in Resource-Limited Settings: A Systematic ReviewBackground The increasing availability of antiretroviral therapy (ART) has improved survival and quality of life for many infected with HIV, but can also engender drug resistance. This review summarizes the available information on drug resistance in adults in resource-limited settings. Methods T...
Tập 18 Số 1 - Trang 115-123 - 2013
Comprehensive assessment of 2009 Pandemic Influenza a (H1N1) Virus Drug Susceptibility in vitroBackground Antiviral drugs are an important option for managing infections caused by influenza viruses. This study assessed the drug susceptibility of 2009 pandemic influenza A (H1N1) viruses collected globally between April 2009 and January 2010. Methods Virus isolates were tested for adamant...
Tập 15 Số 8 - Trang 1151-1159 - 2010
Investigation of Baseline Susceptibility to Protease Inhibitors in HIV-1 Subtypes C, F, G and Crf02_AgObjective To compare baseline susceptibility to protease inhibitors among HIV-1 isolates of subtypes C, F, G and CRF02_AG, and to identify polymorphisms that determine the differences in susceptibility. Methods A total of 42 samples of drug-naive patients infected with subtypes G ( n=19), CRF0...
Tập 11 Số 5 - Trang 581-589 - 2006
HIV-1 Subtypes and Response to Combination Antiretroviral Therapy in EuropeBackground Combination antiretroviral therapy (cART) may vary in ability to suppress viral load and increase CD4+ T-cell count in people infected with different HIV-1 subtypes, possibly due to differences in resistance development. Antiretroviral drugs have predominantly been developed in Western Europe/North America on the basis of t...
Tập 11 Số 6 - Trang 707-716 - 2006
Silymarin for HCV infection Silymarin, an extract of milk thistle seeds, and silymarin-derived compounds have been considered hepatoprotective since the plant was first described in ancient times. Hepatoprotection is defined as several non-mutually exclusive biological activities including antiviral, antioxidant, anti-inflammatory and immunomodulatory functions. Despite clear evidence for silymarin-induced hepatopro... ... hiện toàn bộ
Tập 18 Số 2 - Trang 141-147 - 2013
Mitochondrial (Mt)Dna Changes in Tissue May Not be Reflected by Depletion of Mtdna in Peripheral Blood Mononuclear Cells in HIV-Infected PatientsObjectives Most data on mitochondrial toxicity have been derived from peripheral blood mononuclear cells (PBMCs). However, whether mitochondrial DNA (mtDNA) content in PBMCs reflects the mitochondrial state in tissues remains elusive. We report herein on mitochondrial toxicity in skeletal muscle in HIV-infected patients naive to antiretroviral treatment (...
Tập 11 Số 5 - Trang 601-608 - 2006
High Incidence of Non-B and Recombinant HIV-1 Strains in Newly Diagnosed Patients in Galicia, Spain: Study of Genotypic ResistanceThe objectives of this study are to describe the incidence of non-B and recombinant HIV-1 strains in newly diagnosed HIV-1 infections in Galicia, northwest of Spain, during a 2-year period (May 2000 to June 2002), and the frequency of resistance-associated mutations in reverse transcriptase (RT) and protease (PR) genes, analysing the polymorphisms more frequently detected in non-B and reco... ... hiện toàn bộ
Tập 8 Số 4 - Trang 355-360 - 2003
Safety and Efficacy of Once-Daily Nevirapine Dosing: A Multicohort StudyBackground Nevirapine (NVP) is often prescribed once daily in clinical practice in combination with a once daily nucleoside backbone. We investigated the relationship of NVP dosing with safety and efficacy. Methods Patients from the Dutch AIDS Therapy Evaluation in the Netherlands (ATHENA) coh...
Tập 14 Số 7 - Trang 931-938 - 2009
Liver Triglyceride Content in HIV-1-Infected Patients on Combination Antiretroviral Therapy Studied with 1H-MR SpectroscopyObjective To carry out an exploratory evaluation of liver triglyceride content in HIV-1-infected patients receiving highly active antiretroviral therapy (HAART) using proton magnetic resonance spectroscopy and to study how both the treatment itself and the biochemical and physiological variables in which the treatment causes alterations are related to liv...
Tập 12 Số 2 - Trang 195-204 - 2007