Antiviral Therapy

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* Dữ liệu chỉ mang tính chất tham khảo

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Worldwide Prevalence of Baseline Resistance-Associated Polymorphisms and Resistance Mutations in HCV against Current Direct-Acting Antivirals
Antiviral Therapy - Tập 23 Số 6 - Trang 485-493 - 2018
Navaneethan Palanisamy, Prabhav Kalaghatgi, Dario Akaberi, Åke Lundkvist, Zhiwei Chen, Peng Hu, Johan Lennerstrand
Background HCV infections can now be completely cured, thanks to the currently marketed direct-acting antivirals (DAAs). It is known that HCV patients carry viral populations with baseline polymorphisms and/or mutations that make them resistant against some of these DAAs, which can negatively impact the patient's treatment outcome. Using complete HCV codi...... hiện toàn bộ
Amantadine-Oseltamivir Combination therapy for H5N1 Influenza Virus Infection in Mice
Antiviral Therapy - Tập 12 Số 3 - Trang 363-370 - 2007
Natalia A. Ilyushina, Erich Hoffmann, Rachelle Salomon, Robert G. Webster, Elena A. Govorkova
Background The clinical management of H5N1 influenza virus infection in humans remains unclear. Combination chemotherapy with drugs that target different viral proteins might be more effective than monotherapy. Methods BALB/c mice were treated by oral gavage for 5 days with amantadine (1.5, 15...... hiện toàn bộ
Comprehensive assessment of 2009 Pandemic Influenza a (H1N1) Virus Drug Susceptibility in vitro
Antiviral Therapy - Tập 15 Số 8 - Trang 1151-1159 - 2010
Larisa V. Gubareva, A. Angelica Trujillo, Margaret Okomo‐Adhiambo, Vasiliy P. Mishin, Varough Deyde, Katrina Sleeman, Ha Nguyen, Tiffany G. Sheu, Rebecca Garten, Michael W. Shaw, Alicia M. Fry, Alexander Klimov
Background Antiviral drugs are an important option for managing infections caused by influenza viruses. This study assessed the drug susceptibility of 2009 pandemic influenza A (H1N1) viruses collected globally between April 2009 and January 2010. Methods Virus isolates were tested for adamant...... hiện toàn bộ
Liver Triglyceride Content in HIV-1-Infected Patients on Combination Antiretroviral Therapy Studied with 1H-MR Spectroscopy
Antiviral Therapy - Tập 12 Số 2 - Trang 195-204 - 2007
Àngel Moreno‐Torres, Peré Domingo, Jesús Pujol Salud, Francisco Blanco‐Vaca, Juan Antonio Arroyo, M. A. Sambeat
Objective To carry out an exploratory evaluation of liver triglyceride content in HIV-1-infected patients receiving highly active antiretroviral therapy (HAART) using proton magnetic resonance spectroscopy and to study how both the treatment itself and the biochemical and physiological variables in which the treatment causes alterations are related to liv...... hiện toàn bộ
Silymarin for HCV infection
Antiviral Therapy - Tập 18 Số 2 - Trang 141-147 - 2013
Stephen J. Polyak, Nicholas H. Oberlies, Eve‐Isabelle Pécheur, Harel Dahari, Peter Ferenci, Jean‐Michel Pawlotsky
Silymarin, an extract of milk thistle seeds, and silymarin-derived compounds have been considered hepatoprotective since the plant was first described in ancient times. Hepatoprotection is defined as several non-mutually exclusive biological activities including antiviral, antioxidant, anti-inflammatory and immunomodulatory functions. Despite clear evidence for silymarin-induced hepatopro...... hiện toàn bộ
Exploiting Information Inherent in Binding Sites of Virus-Specific Antibodies: Design of An HCV Vaccine Candidate Cross-Reactive with Multiple Genotypes
Antiviral Therapy - Tập 11 Số 8 - Trang 1005-1014 - 2006
Lara Grollo, Joseph Torresi, Heidi E. Drummer, Weiguang Zeng, Nicholas A. Williamson, David C. Jackson
Background/AimsThe role of antibody in hepatitis C virus (HCV) infection remains unclear although many reports attest to its role in viral clearance. Here we describe epitopes that are recognized by antibody present in the serum of infected patients and show that such epitopes can induce neutralizing antibodies.Me...... hiện toàn bộ
Incidence and Determinants of Severe Morbidity among HIV-Infected Patients from Rio De Janeiro, Brazil, 2000–2010
Antiviral Therapy - Tập 19 Số 4 - Trang 387-397 - 2014
Sayonara Ribeiro, Paula M. Luz, Dayse Pereira Campos, Ronaldo I. Moreira, Lara E. Coelho, André Miguel Japiassú, Fernando A. Bozza, Valdiléa G. Veloso, Geneviève Chêne, Beatriz Grinsztejn
Background Reliable information on severe morbidity is essential for identifying priorities for case management and to guide resource allocation within the health sector. Methods This study describes overall, AIDS- and non-AIDS-related severe morbidity as well as mortality and its determinants...... hiện toàn bộ
HIV-1 Subtypes and Response to Combination Antiretroviral Therapy in Europe
Antiviral Therapy - Tập 11 Số 6 - Trang 707-716 - 2006
Wendy Bannister, Lı́dia Ruiz, Clive Loveday, Stefano Vella, Kai Zilmer, Jesper Kjær, Brygida Knysz, Andrew Carr, Amanda Mocroft, Jens Lundgren
Background Combination antiretroviral therapy (cART) may vary in ability to suppress viral load and increase CD4+ T-cell count in people infected with different HIV-1 subtypes, possibly due to differences in resistance development. Antiretroviral drugs have predominantly been developed in Western Europe/North America on the basis of t...... hiện toàn bộ
High Incidence of Non-B and Recombinant HIV-1 Strains in Newly Diagnosed Patients in Galicia, Spain: Study of Genotypic Resistance
Antiviral Therapy - Tập 8 Số 4 - Trang 355-360 - 2003
Lucía Pérez-Álvarez, Rocı́o Carmona, Mercedes Muñoz, Elena Delgado, Michael M. Thomson, Gerardo Contreras, J. Pedreira, Rafael Rodríguez Real, Elena Vázquez de Parga, Leandro Medrano, José Antonio Franco Taboada, Rafael Nájera, A Agulla, Ana Mariño, Soledad López‐Calvo, Pedreira Jd, Antonio Aguilera, Elena Losada, Arturo Prieto, Juan Corredoira, MJ López- Alvarez, A. Rodríguez, Matilde Bustillo, Isabel García-Bermejo, Juan Carlos Piñeiro-Fernández, Ronald Rodríguez, Celia Miralles, Antonio Ocampo, R. Rodriguez-Real, Julio Diz-Arén, Rafael Ojea de Castro, LE Morano, R Pérez-Rodríguez, José Manuel Torres
The objectives of this study are to describe the incidence of non-B and recombinant HIV-1 strains in newly diagnosed HIV-1 infections in Galicia, northwest of Spain, during a 2-year period (May 2000 to June 2002), and the frequency of resistance-associated mutations in reverse transcriptase (RT) and protease (PR) genes, analysing the polymorphisms more frequently detected in non-B and reco...... hiện toàn bộ
Investigation of Baseline Susceptibility to Protease Inhibitors in HIV-1 Subtypes C, F, G and Crf02_Ag
Antiviral Therapy - Tập 11 Số 5 - Trang 581-589 - 2006
Ana Abecasis, Koen Deforche, Lee T. Bacheler, Paula McKenna, Jonathan Schapiro, Perpétua Gómes, Anne‐Mieke Vandamme, Ricardo Camacho
Objective To compare baseline susceptibility to protease inhibitors among HIV-1 isolates of subtypes C, F, G and CRF02_AG, and to identify polymorphisms that determine the differences in susceptibility. Methods A total of 42 samples of drug-naive patients infected with subtypes G ( n=19), CRF0...... hiện toàn bộ
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