Antiviral Therapy

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Worldwide Prevalence of Baseline Resistance-Associated Polymorphisms and Resistance Mutations in HCV against Current Direct-Acting Antivirals
Antiviral Therapy - Tập 23 Số 6 - Trang 485-493 - 2018
Navaneethan Palanisamy, Prabhav Kalaghatgi, Dario Akaberi, Åke Lundkvist, Zhiwei Chen, Peng Hu, Johan Lennerstrand
Background HCV infections can now be completely cured, thanks to the currently marketed direct-acting antivirals (DAAs). It is known that HCV patients carry viral populations with baseline polymorphisms and/or mutations that make them resistant against some of these DAAs, which can negatively impact the patient's treatment outcome. Using complete HCV coding sequences isolated from 1,306 treatment-... hiện toàn bộ
Incidence and Determinants of Severe Morbidity among HIV-Infected Patients from Rio De Janeiro, Brazil, 2000–2010
Antiviral Therapy - Tập 19 Số 4 - Trang 387-397 - 2014
Sayonara Ribeiro, Paula M. Luz, Dayse Pereira Campos, Ronaldo I. Moreira, Lara E. Coelho, André Miguel Japiassú, Fernando A. Bozza, Valdiléa G. Veloso, Geneviève Chêne, Beatriz Grinsztejn
Background Reliable information on severe morbidity is essential for identifying priorities for case management and to guide resource allocation within the health sector. Methods This study describes overall, AIDS- and non-AIDS-related severe morbidity as well as mortality and its determinants in an urban cohort of HIV-infected individuals from a public healthcare institution, the Evandro Chagas R... hiện toàn bộ
HIV-1 Subtypes and Response to Combination Antiretroviral Therapy in Europe
Antiviral Therapy - Tập 11 Số 6 - Trang 707-716 - 2006
Wendy Bannister, Lı́dia Ruiz, Clive Loveday, Stefano Vella, Kai Zilmer, Jesper Kjær, Brygida Knysz, Andrew Carr, Amanda Mocroft, Jens Lundgren
Background Combination antiretroviral therapy (cART) may vary in ability to suppress viral load and increase CD4+ T-cell count in people infected with different HIV-1 subtypes, possibly due to differences in resistance development. Antiretroviral drugs have predominantly been developed in Western Europe/North America on the basis of the most prevalent subtype, B. However, non-B subtypes are increa... hiện toàn bộ
High Incidence of Non-B and Recombinant HIV-1 Strains in Newly Diagnosed Patients in Galicia, Spain: Study of Genotypic Resistance
Antiviral Therapy - Tập 8 Số 4 - Trang 355-360 - 2003
Lucía Pérez-Álvarez, Rocı́o Carmona, Mercedes Muñoz, Elena Delgado, Michael M. Thomson, Gerardo Contreras, J. Pedreira, Rafael Rodríguez Real, Elena Vázquez de Parga, Leandro Medrano, José Antonio Franco Taboada, Rafael Nájera, A Agulla, Ana Mariño, Soledad López‐Calvo, Pedreira Jd, Antonio Aguilera, Elena Losada, Arturo Prieto, Juan Corredoira, MJ López- Alvarez, A. Rodríguez, Matilde Bustillo, Isabel García-Bermejo, Juan Carlos Piñeiro-Fernández, Ronald Rodríguez, Celia Miralles, Antonio Ocampo, R. Rodriguez-Real, Julio Diz-Arén, Rafael Ojea de Castro, LE Morano, R Pérez-Rodríguez, José Manuel Torres
The objectives of this study are to describe the incidence of non-B and recombinant HIV-1 strains in newly diagnosed HIV-1 infections in Galicia, northwest of Spain, during a 2-year period (May 2000 to June 2002), and the frequency of resistance-associated mutations in reverse transcriptase (RT) and protease (PR) genes, analysing the polymorphisms more frequently detected in non-B and recombinant ... hiện toàn bộ
Investigation of Baseline Susceptibility to Protease Inhibitors in HIV-1 Subtypes C, F, G and Crf02_Ag
Antiviral Therapy - Tập 11 Số 5 - Trang 581-589 - 2006
Ana Abecasis, Koen Deforche, Lee T. Bacheler, Paula McKenna, Jonathan Schapiro, Perpétua Gómes, Anne‐Mieke Vandamme, Ricardo Camacho
Objective To compare baseline susceptibility to protease inhibitors among HIV-1 isolates of subtypes C, F, G and CRF02_AG, and to identify polymorphisms that determine the differences in susceptibility. Methods A total of 42 samples of drug-naive patients infected with subtypes G ( n=19), CRF02_AG ( n=10), F ( n=6) and C ( n=7) were phenotyped and genotyped with the Antivirogram and the ViroSeq 2.... hiện toàn bộ
Amantadine-Oseltamivir Combination therapy for H5N1 Influenza Virus Infection in Mice
Antiviral Therapy - Tập 12 Số 3 - Trang 363-370 - 2007
Natalia A. Ilyushina, Erich Hoffmann, Rachelle Salomon, Robert G. Webster, Elena A. Govorkova
Background The clinical management of H5N1 influenza virus infection in humans remains unclear. Combination chemotherapy with drugs that target different viral proteins might be more effective than monotherapy. Methods BALB/c mice were treated by oral gavage for 5 days with amantadine (1.5, 15 or 30 mg/kg/day) and oseltamivir (1 or 10 mg/kg/day) separately or in combination. Mice were challenged 2... hiện toàn bộ
Comprehensive assessment of 2009 Pandemic Influenza a (H1N1) Virus Drug Susceptibility in vitro
Antiviral Therapy - Tập 15 Số 8 - Trang 1151-1159 - 2010
Larisa V. Gubareva, A. Angelica Trujillo, Margaret Okomo‐Adhiambo, Vasiliy P. Mishin, Varough Deyde, Katrina Sleeman, Ha Nguyen, Tiffany G. Sheu, Rebecca Garten, Michael W. Shaw, Alicia M. Fry, Alexander Klimov
Background Antiviral drugs are an important option for managing infections caused by influenza viruses. This study assessed the drug susceptibility of 2009 pandemic influenza A (H1N1) viruses collected globally between April 2009 and January 2010. Methods Virus isolates were tested for adamantane susceptibility, using pyrosequencing to detect the S31N marker of adamantane resistance in the M2 prot... hiện toàn bộ
Safety and Efficacy of Once-Daily Nevirapine Dosing: A Multicohort Study
Antiviral Therapy - Tập 14 Số 7 - Trang 931-938 - 2009
Alexandra Calmy, N Vallier, Alain Nguyen, Joep MA Lange, Manuel Battegay, Frank de Wolf, Peter Reiss, Viviane D. Lima, Bernard Hirschel, Robert S. Hogg, Benita Yip, Julio Montaner, Ferdinand W.N.M. Wit
Background Nevirapine (NVP) is often prescribed once daily in clinical practice in combination with a once daily nucleoside backbone. We investigated the relationship of NVP dosing with safety and efficacy. Methods Patients from the Dutch AIDS Therapy Evaluation in the Netherlands (ATHENA) cohort study, Canadian HAART Observational Medical Evaluation and Research (HOMER) cohort and Swiss HIV Cohor... hiện toàn bộ
Exploiting Information Inherent in Binding Sites of Virus-Specific Antibodies: Design of An HCV Vaccine Candidate Cross-Reactive with Multiple Genotypes
Antiviral Therapy - Tập 11 Số 8 - Trang 1005-1014 - 2006
Lara Grollo, Joseph Torresi, Heidi E. Drummer, Weiguang Zeng, Nicholas A. Williamson, David C. Jackson
Background/AimsThe role of antibody in hepatitis C virus (HCV) infection remains unclear although many reports attest to its role in viral clearance. Here we describe epitopes that are recognized by antibody present in the serum of infected patients and show that such epitopes can induce neutralizing antibodies.MethodsHuman serum containing hyperimmune anti-HCV IgG was used to extract epitopes fro... hiện toàn bộ
Mitochondrial (Mt)Dna Changes in Tissue May Not be Reflected by Depletion of Mtdna in Peripheral Blood Mononuclear Cells in HIV-Infected Patients
Antiviral Therapy - Tập 11 Số 5 - Trang 601-608 - 2006
Anne Maagaard, Mona Holberg‐Petersen, Gittan Kollberg, Anders Oldfors, Leiv Sandvik, Johan N. Bruun
Objectives Most data on mitochondrial toxicity have been derived from peripheral blood mononuclear cells (PBMCs). However, whether mitochondrial DNA (mtDNA) content in PBMCs reflects the mitochondrial state in tissues remains elusive. We report herein on mitochondrial toxicity in skeletal muscle in HIV-infected patients naive to antiretroviral treatment (ART [HIV+ART-naive]; n=10) patients exposed... hiện toàn bộ
Tổng số: 13   
  • 1
  • 2