Silymarin for HCV infection

Antiviral Therapy - Tập 18 Số 2 - Trang 141-147 - 2013
Stephen J. Polyak1,2,3, Nicholas H. Oberlies4, Eve‐Isabelle Pécheur5, Harel Dahari6,7,8, Peter Ferenci9, Jean‐Michel Pawlotsky10,11
1Department of Global Health, University of Washington, Seattle, WA USA
2Department of Laboratory Medicine, University of Washington, Seattle, WA, USA
3Department of Microbiology, University of Washington, Seattle, WA, USA
4Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA
5UMR INSERM 1052/CNRS 5286, Lyon, France
6Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
7Present address: Department of Medicine, Division of Hepatology, Loyola University Chicago, Maywood, IL, USA
8Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, USA
9Internal Medicine 3, Medical University of Vienna, Vienna, Austria
10Inserm U955, Créteil, France
11National Reference Center for Viral Hepatitis B, C and Delta, Department of Virology, Henri Mondor Hospital, University of Paris-Est, Créteil, France

Tóm tắt

Silymarin, an extract of milk thistle seeds, and silymarin-derived compounds have been considered hepatoprotective since the plant was first described in ancient times. Hepatoprotection is defined as several non-mutually exclusive biological activities including antiviral, antioxidant, anti-inflammatory and immunomodulatory functions. Despite clear evidence for silymarin-induced hepatoprotection in cell culture and animal models, evidence for benefcial effects in humans has been equivocal. This review will summarize the current state of knowledge on silymarin in the context of HCV infection. The information was collated from a recent workshop on silibinin in Germany.

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Antiviral Therapy

Tập 18 Số 2

141-147

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