Antimicrobial Agents and Chemotherapy

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Human Volunteers Receiving Escherichia coli Phage T4 Orally: a Safety Test of Phage Therapy
Antimicrobial Agents and Chemotherapy - Tập 49 Số 7 - Trang 2874-2878 - 2005
Anne Bruttin, Harald Brüssow
ABSTRACT Fifteen healthy adult volunteers received in their drinking water a lower Escherichia coli phage T4 dose (10 3 PFU/ml), a higher phage dose (10 5 PFU/ml), and placebo. Fecal coliphage was detected in a dose-dependent way in volunteers orally exposed to phage. All volunteers receiving the higher phage dose showed fecal phage 1 day after exposure; this prevalence was only 50% in subjects re... hiện toàn bộ
Slow Release of Nitric Oxide from Charged Catheters and Its Effect on Biofilm Formation by Escherichia coli
Antimicrobial Agents and Chemotherapy - Tập 54 Số 1 - Trang 273-279 - 2010
G. Regev-Shoshani, Mary Ko, Christopher Miller, Yossef Av‐Gay
ABSTRACT Catheter-associated urinary tract infection is the most prevalent cause of nosocomial infections. Bacteria associated with biofilm formation play a key role in the morbidity and pathogenesis of these infections. Nitric oxide (NO) is a naturally produced free radical with proven bactericidal effect. In this study, Foley urinary catheters were impregnated with gaseous NO. The catheters demo... hiện toàn bộ
Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: in vitro comparative studies
Antimicrobial Agents and Chemotherapy - Tập 23 Số 3 - Trang 440-449 - 1983
Marie-Béatrice Carlier, G. Laurent, P. Claes, H. Vanderhaeghe, Paul M. Tulkens
Aminoglycoside antibiotics induce an early and characteristic lysosomal phospholipidosis in cultured fibroblasts and in kidney tubular cells. We have recently demonstrated an inhibition of lysosomal phospholipases A1 and A2 by gentamicin and amikacin in vitro. In vivo, gentamicin decreases the activity of phospholipase A1 (Laurent et al., Biochem. Pharmacol. 31:3861-3870, 1982). In the present stu... hiện toàn bộ
Class D tetracycline resistance determinants of R plasmids from the fish pathogens Aeromonas hydrophila, Edwardsiella tarda, and Pasteurella piscicida
Antimicrobial Agents and Chemotherapy - Tập 31 Số 8 - Trang 1278-1280 - 1987
Takashi Aoki, Akira Takahashi
Tetracycline resistance determinants of R plasmids from the fish pathogens Aeromonas hydrophila, Edwardsiella tarda, and Pasteurella piscicida were classified as class D by their expression of resistance to tetracycline and minocycline and through their DNA structure.
Antibacterial Activity of Ultrashort Cationic Lipo-β-Peptides
Antimicrobial Agents and Chemotherapy - Tập 53 Số 5 - Trang 2215-2217 - 2009
Griselda N. Serrano, George G. Zhanel, Frank Schweizer
ABSTRACT Previously reported d , l -lipo-α-peptides and their lipo-β-peptide counterparts (C16-KGGK, C16-KAAK, C16-KKKK, and C12-KLLK) were studied, and the lipo-β-peptides were found to retain antimicrobial activity. Likewise, no significant changes in antimicrobial activity were found upon activity comparisons with d , l -amino acid-based lipopeptides or any l -amino acid lipopeptides. As a defi... hiện toàn bộ
Cationic Amphiphiles, a New Generation of Antimicrobials Inspired by the Natural Antimicrobial Peptide Scaffold
Antimicrobial Agents and Chemotherapy - Tập 54 Số 10 - Trang 4049-4058 - 2010
Brandon Findlay, George G. Zhanel, Frank Schweizer
ABSTRACT Naturally occurring cationic antimicrobial peptides (AMPs) and their mimics form a diverse class of antibacterial agents currently validated in preclinical and clinical settings for the treatment of infections caused by antimicrobial-resistant bacteria. Numerous studies with linear, cyclic, and diastereomeric AMPs have strongly supported the hypothesis that their physicochemical propertie... hiện toàn bộ
Antimicrobial-Resistant Pathogens in Intensive Care Units in Canada: Results of the Canadian National Intensive Care Unit (CAN-ICU) Study, 2005-2006
Antimicrobial Agents and Chemotherapy - Tập 52 Số 4 - Trang 1430-1437 - 2008
George G. Zhanel, Mel DeCorby, Nancy M. Laing, Barb Weshnoweski, Ravi Vashisht, Franil Tailor, Kim Nichol, Aleksandra Wierzbowski, Patricia J. Baudry, James A. Karlowsky, Philippe Lagacé‐Wiens, Andrew Walkty, Melissa McCracken, Michael R. Mulvey, Jack Johnson, Daryl J. Hoban
ABSTRACT Between 1 September 2005 and 30 June 2006, 19 medical centers collected 4,180 isolates recovered from clinical specimens from patients in intensive care units (ICUs) in Canada. The 4,180 isolates were collected from 2,292 respiratory specimens (54.8%), 738 blood specimens (17.7%), 581 wound/tissue specimens (13.9%), and 569 urinary specimens (13.6%). The 10 most common organisms isolated ... hiện toàn bộ
In Vitro Antibacterial Properties of Pexiganan, an Analog of Magainin
Antimicrobial Agents and Chemotherapy - Tập 43 Số 4 - Trang 782-788 - 1999
Yigong Ge, Dorothy L. MacDonald, Kenneth J. Holroyd, Clyde Thornsberry, Hannah M. Wexler, Michael Zasloff
ABSTRACT Pexiganan, a 22-amino-acid antimicrobial peptide, is an analog of the magainin peptides isolated from the skin of the African clawed frog. Pexiganan exhibited in vitro broad-spectrum antibacterial activity when it was tested against 3,109 clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria. The pexiganan MIC at which 90% of isolates are inhibited (MIC 90 )... hiện toàn bộ
Comparative evaluation of the 2-methyl-5-nitroimidazole compounds dimetridazole, metronidazole, secnidazole, ornidazole, tinidazole, carnidazole, and panidazole against Bacteroides fragilis and other bacteria of the Bacteroides fragilis group
Antimicrobial Agents and Chemotherapy - Tập 28 Số 4 - Trang 561-564 - 1985
Liisa Jokipii, A. M. M. Jokipii
Tube-dilution MICs of seven 2-methyl-5-nitroimidazole compounds varying at the 1-substitution were determined against Bacteroides fragilis. Activities on a molar basis were ranked: tinidazole greater than panidazole greater than ornidazole greater than metronidazole greater than or equal to secnidazole greater than carnidazole greater than dimetridazole. Geometric mean MICs varied from 0.5 to 6.6 ... hiện toàn bộ
Candida tropicalis Antifungal Cross-Resistance Is Related to Different Azole Target (Erg11p) Modifications
Antimicrobial Agents and Chemotherapy - Tập 57 Số 10 - Trang 4769-4781 - 2013
Agustina Forastiero, Ana Cecilia Mesa-Arango, Ana Alastruey‐Izquierdo, Laura Alcàzar-Fuoli, Leticia Bernal‐Martínez, Teresa Peláez, Jordi F. López, Joan O. Grimalt, Alicia Gómez‐López, Isabel Cuesta, Óscar Zaragoza, Emilia Mellado
ABSTRACT Candida tropicalis ranks between third and fourth among Candida species most commonly isolated from clinical specimens. Invasive candidiasis and candidemia are treated with amphotericin B or echinocandins as first-line therapy, with extended-spectrum triazoles as acceptable alternatives. Candida tropicalis is usually susceptible to all antifungal agents, although several azole drug-resist... hiện toàn bộ
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