Slow Release of Nitric Oxide from Charged Catheters and Its Effect on Biofilm Formation by Escherichia coliAntimicrobial Agents and Chemotherapy - Tập 54 Số 1 - Trang 273-279 - 2010
G. Regev-Shoshani, Mary Ko, Christopher Miller, Yossef Av‐Gay
ABSTRACT
Catheter-associated urinary tract infection is the most prevalent cause of nosocomial infections. Bacteria associated with biofilm formation play a key role in the morbidity and pathogenesis of these infections. Nitric oxide (NO) is a naturally produced free radical with proven bactericidal effect. In this study, Foley urinary cathet...... hiện toàn bộ
Antibacterial Activity of Ultrashort Cationic Lipo-β-PeptidesAntimicrobial Agents and Chemotherapy - Tập 53 Số 5 - Trang 2215-2217 - 2009
Griselda N. Serrano, George G. Zhanel, Frank Schweizer
ABSTRACT
Previously reported
d
,
l
-lipo-α-peptides and their lipo-β-peptide counterparts (C16-KGGK, C16-KAAK, C16-KKKK, and C12-KLLK) were studied, and the lipo-β-peptides were found to retain antimicrobial activity. Likewise, no significant changes in anti...... hiện toàn bộ
Cationic Amphiphiles, a New Generation of Antimicrobials Inspired by the Natural Antimicrobial Peptide ScaffoldAntimicrobial Agents and Chemotherapy - Tập 54 Số 10 - Trang 4049-4058 - 2010
Brandon Findlay, George G. Zhanel, Frank Schweizer
ABSTRACT
Naturally occurring cationic antimicrobial peptides (AMPs) and their mimics form a diverse class of antibacterial agents currently validated in preclinical and clinical settings for the treatment of infections caused by antimicrobial-resistant bacteria. Numerous studies with linear, cyclic, and diastereomeric AMPs have strongly suppo...... hiện toàn bộ
In Vitro Antibacterial Properties of Pexiganan, an Analog of MagaininAntimicrobial Agents and Chemotherapy - Tập 43 Số 4 - Trang 782-788 - 1999
Yigong Ge, Dorothy L. MacDonald, Kenneth J. Holroyd, Clyde Thornsberry, Hannah M. Wexler, Michael Zasloff
ABSTRACT
Pexiganan, a 22-amino-acid antimicrobial peptide, is an analog of the magainin peptides isolated from the skin of the African clawed frog. Pexiganan exhibited in vitro broad-spectrum antibacterial activity when it was tested against 3,109 clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria. The pexiga...... hiện toàn bộ
Candida tropicalis Antifungal Cross-Resistance Is Related to Different Azole Target (Erg11p) ModificationsAntimicrobial Agents and Chemotherapy - Tập 57 Số 10 - Trang 4769-4781 - 2013
Agustina Forastiero, Ana Cecilia Mesa-Arango, Ana Alastruey‐Izquierdo, Laura Alcàzar-Fuoli, Leticia Bernal‐Martínez, Teresa Peláez, Jordi F. López, Joan O. Grimalt, Alicia Gómez‐López, Isabel Cuesta, Óscar Zaragoza, Emilia Mellado
ABSTRACT
Candida tropicalis
ranks between third and fourth among
Candida
species most commonly isolated from clinical specimens. Invasive candidiasis and candidemia are treated with amphotericin B or echinocandins as first-line therapy, with extended-spectrum triazoles as acceptable alternatives.
Candida tropicalis
is usually susceptible to all antifungal agents, although several azole drug-resistant clinical isolates are being reported. However,
C. tropicalis
resistant to amphotericin B is uncommon, and only a few strains have reliably demonstrated a high level of resistance to this agent. The resistance mechanisms operating in
C. tropicalis
strains isolated from clinical samples showing resistance to azole drugs alone or with amphotericin B cross-resistance were elucidated. Antifungal drug resistance was related to mutations of the azole target (Erg11p) with or without alterations of the ergosterol biosynthesis pathway. The antifungal drug resistance shown
in vitro
correlated very well with the results obtained
in vivo
using the model host
Galleria mellonella
. Using this panel of strains, the
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Substantial Targeting Advantage Achieved by Pulmonary Administration of Colistin Methanesulfonate in a Large-Animal ModelAntimicrobial Agents and Chemotherapy - Tập 61 Số 1 - 2017
Cornelia B. Landersdorfer, Tri‐Hung Nguyen, Linh Thuy Lieu, Gary Nguyen, Robert J. Bischof, Els Meeusen, Jian Li, Roger L. Nation, Michelle P. McIntosh
ABSTRACT
Colistin, administered as its inactive prodrug colistin methanesulfonate (CMS), is often used in multidrug-resistant Gram-negative pulmonary infections. The CMS and colistin pharmacokinetics in plasma and epithelial lining fluid (ELF) following intravenous and pulmonary dosing have not been evaluated in a large-animal model with pulmonary archite...... hiện toàn bộ
The Bioactive Lipid 4-Hydroxyphenyl Retinamide Inhibits Flavivirus ReplicationAntimicrobial Agents and Chemotherapy - Tập 59 Số 1 - Trang 85-95 - 2015
Margot Carocci, Stephen M. Hinshaw, Mary A. Rodgers, Valerie A. Villareal, Dominique J. Burri, Rajendra Pilankatta, Natalya P. Maharaj, Michaela U. Gack, Eric Stavale, Kelly L. Warfield, Priscilla L. Yang
ABSTRACT
Dengue virus (DENV), a member of the
Flaviviridae
family, is a mosquito-borne pathogen and the cause of dengue fever. The increasing prevalence of DENV worldwide heightens the need for an effective vaccine and specific antivirals. Due to the dependence of DENV upon the lipid biosynthetic machinery of the host cell, lipid signaling and metabolism present unique opportunities for inhibiting viral replication. We screened a library of bioactive lipids and modulators of lipid metabolism and identified 4-hydroxyphenyl retinamide (4-HPR) (fenretinide) as an inhibitor of DENV in cell culture. 4-HPR inhibits the steady-state accumulation of viral genomic RNA and reduces viremia when orally administered in a murine model of DENV infection. The molecular target responsible for this antiviral activity is distinct from other known inhibitors of DENV but appears to affect other members of the
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