Slow Release of Nitric Oxide from Charged Catheters and Its Effect on Biofilm Formation by Escherichia coliAntimicrobial Agents and Chemotherapy - Tập 54 Số 1 - Trang 273-279 - 2010
G. Regev-Shoshani, Mary Ko, Christopher Miller, Yossef Av‐Gay
ABSTRACT
Catheter-associated urinary tract infection is the most prevalent cause of nosocomial infections. Bacteria associated with biofilm formation play a key role in the morbidity and pathogenesis of these infections. Nitric oxide (NO) is a naturally produced free radical with proven bactericidal effect. In this study, Foley urinary cathet...... hiện toàn bộ
Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: in vitro comparative studiesAntimicrobial Agents and Chemotherapy - Tập 23 Số 3 - Trang 440-449 - 1983
Marie-Béatrice Carlier, G. Laurent, P. Claes, H. Vanderhaeghe, Paul M. Tulkens
Aminoglycoside antibiotics induce an early and characteristic lysosomal phospholipidosis in cultured fibroblasts and in kidney tubular cells. We have recently demonstrated an inhibition of lysosomal phospholipases A1 and A2 by gentamicin and amikacin in vitro. In vivo, gentamicin decreases the activity of phospholipase A1 (Laurent et al., Biochem. Pharmacol. 31:3861-3870, 1982). In the pre...... hiện toàn bộ
Antibacterial Activity of Ultrashort Cationic Lipo-β-PeptidesAntimicrobial Agents and Chemotherapy - Tập 53 Số 5 - Trang 2215-2217 - 2009
Griselda N. Serrano, George G. Zhanel, Frank Schweizer
ABSTRACT
Previously reported
d
,
l
-lipo-α-peptides and their lipo-β-peptide counterparts (C16-KGGK, C16-KAAK, C16-KKKK, and C12-KLLK) were studied, and the lipo-β-peptides were found to retain antimicrobial activity. Likewise, no significant changes in anti...... hiện toàn bộ
Cationic Amphiphiles, a New Generation of Antimicrobials Inspired by the Natural Antimicrobial Peptide ScaffoldAntimicrobial Agents and Chemotherapy - Tập 54 Số 10 - Trang 4049-4058 - 2010
Brandon Findlay, George G. Zhanel, Frank Schweizer
ABSTRACT
Naturally occurring cationic antimicrobial peptides (AMPs) and their mimics form a diverse class of antibacterial agents currently validated in preclinical and clinical settings for the treatment of infections caused by antimicrobial-resistant bacteria. Numerous studies with linear, cyclic, and diastereomeric AMPs have strongly suppo...... hiện toàn bộ
Antimicrobial-Resistant Pathogens in Intensive Care Units in Canada: Results of the Canadian National Intensive Care Unit (CAN-ICU) Study, 2005-2006Antimicrobial Agents and Chemotherapy - Tập 52 Số 4 - Trang 1430-1437 - 2008
George G. Zhanel, Mel DeCorby, Nancy M. Laing, Barb Weshnoweski, Ravi Vashisht, Franil Tailor, Kim Nichol, Aleksandra Wierzbowski, Patricia J. Baudry, James A. Karlowsky, Philippe Lagacé‐Wiens, Andrew Walkty, Melissa McCracken, Michael R. Mulvey, Jack Johnson, Daryl J. Hoban
ABSTRACT
Between 1 September 2005 and 30 June 2006, 19 medical centers collected 4,180 isolates recovered from clinical specimens from patients in intensive care units (ICUs) in Canada. The 4,180 isolates were collected from 2,292 respiratory specimens (54.8%), 738 blood specimens (17.7%), 581 wound/tissue specimens (13.9%), and 569 urinary s...... hiện toàn bộ
In Vitro Antibacterial Properties of Pexiganan, an Analog of MagaininAntimicrobial Agents and Chemotherapy - Tập 43 Số 4 - Trang 782-788 - 1999
Yigong Ge, Dorothy L. MacDonald, Kenneth J. Holroyd, Clyde Thornsberry, Hannah M. Wexler, Michael Zasloff
ABSTRACT
Pexiganan, a 22-amino-acid antimicrobial peptide, is an analog of the magainin peptides isolated from the skin of the African clawed frog. Pexiganan exhibited in vitro broad-spectrum antibacterial activity when it was tested against 3,109 clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria. The pexiga...... hiện toàn bộ
Candida tropicalis Antifungal Cross-Resistance Is Related to Different Azole Target (Erg11p) ModificationsAntimicrobial Agents and Chemotherapy - Tập 57 Số 10 - Trang 4769-4781 - 2013
Agustina Forastiero, Ana Cecilia Mesa-Arango, Ana Alastruey‐Izquierdo, Laura Alcàzar-Fuoli, Leticia Bernal‐Martínez, Teresa Peláez, Jordi F. López, Joan O. Grimalt, Alicia Gómez‐López, Isabel Cuesta, Óscar Zaragoza, Emilia Mellado
ABSTRACT
Candida tropicalis
ranks between third and fourth among
Candida
species most commonly isolated from clinical specimens. Invasive candidiasis and candidemia are treated with amphotericin B or echinocandins as first-line therapy, with extended-spectrum triazoles as acceptable alternatives.
Candida tropicalis
is usually susceptible to all antifungal agents, although several azole drug-resistant clinical isolates are being reported. However,
C. tropicalis
resistant to amphotericin B is uncommon, and only a few strains have reliably demonstrated a high level of resistance to this agent. The resistance mechanisms operating in
C. tropicalis
strains isolated from clinical samples showing resistance to azole drugs alone or with amphotericin B cross-resistance were elucidated. Antifungal drug resistance was related to mutations of the azole target (Erg11p) with or without alterations of the ergosterol biosynthesis pathway. The antifungal drug resistance shown
in vitro
correlated very well with the results obtained
in vivo
using the model host
Galleria mellonella
. Using this panel of strains, the
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