Slow Release of Nitric Oxide from Charged Catheters and Its Effect on Biofilm Formation by Escherichia coli

Antimicrobial Agents and Chemotherapy - Tập 54 Số 1 - Trang 273-279 - 2010
G. Regev-Shoshani1, Mary Ko1, Christopher Miller1,2, Yossef Av‐Gay1,3,4
1Department of Medicine, Division of Infectious Diseases
2Department of Medicine, Division of Respiratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
3Department of Microbiology and Immunology
4Enox Biopharma Inc., 3849 13th Avenue West, Vancouver, British Columbia, Canada

Tóm tắt

ABSTRACT Catheter-associated urinary tract infection is the most prevalent cause of nosocomial infections. Bacteria associated with biofilm formation play a key role in the morbidity and pathogenesis of these infections. Nitric oxide (NO) is a naturally produced free radical with proven bactericidal effect. In this study, Foley urinary catheters were impregnated with gaseous NO. The catheters demonstrated slow release of nitric oxide over a 14-day period. The charged catheters were rendered antiseptic, and as such, were able to prevent bacterial colonization and biofilm formation on their luminal and exterior surfaces. In addition, we observed that NO-impregnated catheters were able to inhibit the growth of Escherichia coli within the surrounding media, demonstrating the ability to eradicate a bacterial concentration of up to 10 4 CFU/ml.

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Tài liệu tham khảo

10.1016/S0140-6736(94)92405-8

Biofilm inhibiting catheters and tubings. 2009

10.1034/j.1600-065X.2000.917307.x

10.1128/AAC.49.6.2352-2355.2005

10.1128/JB.186.24.8161-8163.2004

10.1126/science.284.5418.1318

10.1128/IAI.71.5.2341-2349.2003

10.1093/jac/dkn006

10.1093/clinids/21.Supplement_2.S162

10.1172/JCI119473

10.1016/j.niox.2005.08.003

10.1016/j.niox.2005.01.006

10.1016/0003-2697(82)90118-X

10.1016/j.ijantimicag.2006.08.020

Hatt, J. K., and P. N. Rather. 2008. Role of bacterial biofilms in urinary tract infections. Curr. Top. Microbiol. Immunol.322:163-192.

10.1016/j.biomaterials.2007.01.006

10.7326/0003-4819-144-2-200601170-00009

10.1016/0002-9343(55)90190-X

10.1016/0167-5699(91)90107-5

McMullin, B. B., D. R. Chittock, D. L. Roscoe, H. Garcha, L. Wang, and C. C. Miller. 2005. The antimicrobial effect of nitric oxide on the bacteria that cause nosocomial pneumonia in mechanically ventilated patients in the intensive care unit. Respir. Care50:1451-1456.

10.1016/j.niox.2008.08.002

10.1128/AAC.00347-07

Moncada, S., R. M. Palmer, and E. A. Higgs. 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev.43:109-142.

10.1016/j.biomaterials.2005.05.017

10.1046/j.1365-2958.1998.01062.x

10.1097/01.WON.0000345173.05376.3e

10.1056/NEJM198209093071101

10.1016/j.ajic.2007.02.012

10.1007/s00268-003-7396-7

10.1016/S0039-6109(05)70572-7

10.1128/am.10.3.185-189.1962

10.1016/0002-9343(91)90345-X

10.18388/abp.2000_3983

10.1016/j.ijantimicag.2004.02.008

10.1016/j.mib.2003.10.014

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Thông tin xuất bản

Antimicrobial Agents and Chemotherapy

Tập 54 Số 1

273-279

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