Antibacterial Activity of Ultrashort Cationic Lipo-β-Peptides

Antimicrobial Agents and Chemotherapy - Tập 53 Số 5 - Trang 2215-2217 - 2009
Griselda N. Serrano1, George G. Zhanel2, Frank Schweizer2,1
1and Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3A 1R9, Canada
2Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3A 1R9, Canada

Tóm tắt

ABSTRACT Previously reported d , l -lipo-α-peptides and their lipo-β-peptide counterparts (C16-KGGK, C16-KAAK, C16-KKKK, and C12-KLLK) were studied, and the lipo-β-peptides were found to retain antimicrobial activity. Likewise, no significant changes in antimicrobial activity were found upon activity comparisons with d , l -amino acid-based lipopeptides or any l -amino acid lipopeptides. As a defined amphipathic structure is unlikely to form with such short molecules and as similar activities were obtained from all lipopeptides, we suspect that the action of membrane permeation is retained.

Từ khóa


Tài liệu tham khảo

10.1042/BJ20041270

10.1021/bi035142v

10.1074/jbc.M312260200

10.1021/ja067419v

Jerala, R. 2007. Synthetic lipopeptides: a novel class of anti-infectives. Expert Opin. Investig. Drugs16:1159-1169.

10.1093/jac/dkg219

10.1073/pnas.0606129103

Papo, N., and Y. Shai. 2004. Effect of drastic sequence alteration and D-amino acid incorporation on the membrane binding behavior of lytic peptides. Biochemistry43:6393-6403.

Seebach, D., A. K. Beck, and D. J. Bierbaum. 2004. The world of β- and γ-peptides comprised of homologated proteinogenic amino acids and other components. Chem. Biodivers.1:1111-1239.

Shai, Y., A. Makovitzky, and D. Avrahami. 2006. Host defense peptides and lipopeptides: modes of action and potential candidates for the treatment of bacterial and fungal infections. Curr. Protein Pept. Sci.7:479-486.

Steer, D. L., R. A. Lew, P. Perlmutter, A. I. Smith, and M.-I. Aguilar. 2002. β-Amino acids: versatile peptidomimetics. Curr. Med. Chem.9:811-822.

10.1016/j.bbamem.2006.02.009

10.1128/AAC.01538-07

Thông tin
Thông tin xuất bản

Antimicrobial Agents and Chemotherapy

Tập 53 Số 5

2215-2217

Thông tin tác giả