Limited Polymorphism in the Dihydropteroate Synthetase Gene ( dhps ) of Plasmodium vivax Isolates from Thailand

Antimicrobial Agents and Chemotherapy - Tập 49 Số 10 - Trang 4393-4395 - 2005
Mallika Imwong1, Sasithon Pukrittayakamee1, Qin Cheng2, Catrin E. Moore3, Arnaud Fontanet1, Georges Snounou4, Nicholas J. White3,1, Nicholas Day3,1
1Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
2Drug Resistance and Diagnostics Department, Australian Army Malaria Institute, Brisbane, Queensland, Australia
3Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom
4Unité de Parasitologie Biomédicale, CNRS URA 2581, Institut Pasteur, Paris, France

Tóm tắt

ABSTRACT The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pv dhps at codons 383 and/or 553 (A → G) in 33 isolates, all from Thailand. Mutations of Pv dhps and Pv dhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance.

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Tài liệu tham khảo

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Thông tin xuất bản

Antimicrobial Agents and Chemotherapy

Tập 49 Số 10

4393-4395

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