Annual Review of Immunology

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Pathways of Antigen Processing
Annual Review of Immunology - Tập 31 Số 1 - Trang 443-473 - 2013
Janice S. Blum, Pamela A. Wearsch, Peter Cresswell
T cell recognition of antigen-presenting cells depends on their expression of a spectrum of peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules. Conversion of antigens from pathogens or transformed cells into MHC-I- and MHC-II-bound peptides is critical for mounting protective T cell responses, and similar processing of self proteins is necess...... hiện toàn bộ
Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link
Annual Review of Immunology - Tập 8 Số 1 - Trang 421-452 - 1990
Katharine S. Ullman, Jeffrey P. Northrop, C L Verweij, Robert H. Crabtree
Microglial Physiology: Unique Stimuli, Specialized Responses
Annual Review of Immunology - Tập 27 Số 1 - Trang 119-145 - 2009
Richard M. Ransohoff, V. Hugh Perry
Microglia, the macrophages of the central nervous system parenchyma, have in the normal healthy brain a distinct phenotype induced by molecules expressed on or secreted by adjacent neurons and astrocytes, and this phenotype is maintained in part by virtue of the blood-brain barrier's exclusion of serum components. Microglia are continually active, their processes palpating and surveying t...... hiện toàn bộ
IgE-Binding Factors and Regulation of the IgE Antibody Response
Annual Review of Immunology - Tập 6 Số 1 - Trang 513-534 - 1988
K Ishizaka
NaturallyArisingCD4+RegulatoryT Cells forImmunologicSelf-Tolerance andNegativeControl ofImmuneResponses
Annual Review of Immunology - Tập 22 Số 1 - Trang 531-562 - 2004
Shimon Sakaguchi
▪ Abstract  Naturally occurring CD4+regulatory T cells, the majority of which express CD25, are engaged in dominant control of self-reactive T cells, contributing to the maintenance of immunologic self-tolerance. Their depletion or functional alteration leads to the development of autoimmune disease in otherwise normal animals. The majority, if not all, of such CD25... hiện toàn bộ
The Regulation and Expression of c-myc in Normal and Malignant Cells
Annual Review of Immunology - Tập 4 Số 1 - Trang 317-338 - 1986
Kathleen Kelly, Ulrich Siebenlist
Making Antibodies by Phage Display Technology
Annual Review of Immunology - Tập 12 Số 1 - Trang 433-455 - 1994
Greg Winter, Andrew D. Griffiths, Robert E. Hawkins, Hennie R. Hoogenboom
Antibody fragments of predetermined binding specificity have recently been constructed from repertoires of antibody V genes, bypassing hybridoma technology and even immunization. The V gene repertoires are harvested from populations of lymphocytes, or assembled in vitro, and cloned for display of associated heavy and light chain variable domains on the surface of filamentous bacteriophage...... hiện toàn bộ
Immunobiology of Dendritic Cells
Annual Review of Immunology - Tập 18 Số 1 - Trang 767-811 - 2000
Jacques Banchereau, Francine Brière, Christophe Caux, Jean Davoust, Serge Lebecque, Yongjun Liu, Bali Pulendran, Karolina Palucka
Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary immune responses. DCs capture and transfer information from the outside world to the cells of the adaptive immune system. DCs are not only critical for the induction of primary immune responses, but may also be important for the induction of immunological tolerance, as well as for the regulation of t...... hiện toàn bộ
The Dendritic Cell System and its Role in Immunogenicity
Annual Review of Immunology - Tập 9 Số 1 - Trang 271-296 - 1991
R M Steinman
Apoptosis and Programmed Cell Death in Immunity
Annual Review of Immunology - Tập 10 Số 1 - Trang 267-293 - 1992
John Cohen, Richard C. Duke, Valerie A. Fadok, Karen S. Sellins
Death of some cells in the mammalian body is clearly programmed. In the immune system there are many examples of programmed cell death, during development of lymphocytes as well as at later stages, after interaction with antigen. Many of these examples display the morphology of apoptosis: They undergo shrinkage and zeiosis, the nucleus collapses, and chromatin is cleaved into nucleosomal ...... hiện toàn bộ
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