Annual Review of Immunology

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The Three-Dimensional Structure of Peptide-MHC Complexes
Annual Review of Immunology - Tập 13 Số Volume 13, 1995 - Trang 587-622 - 1995
Dean R. Madden
The Dynamic Life of Natural Killer Cells
Annual Review of Immunology - Tập 22 Số 1 - Trang 405-429 - 2004
Wayne M. Yokoyama, Sung‐Jin Kim, Anthony R. French
▪ Abstract  Natural killer (NK) cells play important roles in immunological processes, including early defense against viral infections. This review provides an overview of the dynamic in vivo life of NK cells from their development in the bone marrow to their mature peripheral responses and their ultimate demise, with particular emphasis on mouse NK cells and viral infections.
TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties
Annual Review of Immunology - Tập 7 Số 1 - Trang 145-173 - 1989
Tim R. Mosmann, Robert L. Coffman
Chemokine:Receptor Structure, Interactions, and Antagonism
Annual Review of Immunology - Tập 25 Số 1 - Trang 787-820 - 2007
Samantha J. Allen, Susan E. Crown, Tracy M. Handel
Chemokines are critical mediators of cell migration during routine immune surveillance, inflammation, and development. Chemokines bind to G protein–coupled receptors and cause conformational changes that trigger intracellular signaling pathways involved in cell movement and activation. Although chemokines evolved to benefit the host, inappropriate regulation or utilization of these protein...... hiện toàn bộ
Plasmacytoid Dendritic Cells: Recent Progress and Open Questions
Annual Review of Immunology - Tập 29 Số 1 - Trang 163-183 - 2011
Boris Reizis, Anna Bunin, Hiyaa S. Ghosh, Kanako L. Lewis, Vanja Sisirak
Plasmacytoid dendritic cells (pDCs) are specialized in rapid and massive secretion of type I interferon (IFN-α/β) in response to foreign nucleic acids. Combined with their antigen presentation capacity, this powerful functionality enables pDCs to orchestrate innate and adaptive immune responses. pDCs combine features of both lymphocytes and classical dendritic cells and display unique mol...... hiện toàn bộ
Krebs Cycle Reborn in Macrophage Immunometabolism
Annual Review of Immunology - Tập 38 Số 1 - Trang 289-313 - 2020
Dylan G. Ryan, Luke O'neill
A striking change has happened in the field of immunology whereby specific metabolic processes have been shown to be a critical determinant of immune cell activation. Multiple immune receptor types rewire metabolic pathways as a key part of how they promote effector functions. Perhaps surprisingly for immunologists, the Krebs cycle has emerged as the central immunometabolic hub of the mac...... hiện toàn bộ
NK CELL RECOGNITION
Annual Review of Immunology - Tập 23 Số 1 - Trang 225-274 - 2005
Lewis L. Lanier
▪ Abstract  The integrated processing of signals transduced by activating and inhibitory cell surface receptors regulates NK cell effector functions. Here, I review the structure, function, and ligand specificity of the receptors responsible for NK cell recognition.
The Impact of Glycosylation on the Biological Function and Structure of Human Immunoglobulins
Annual Review of Immunology - Tập 25 Số 1 - Trang 21-50 - 2007
James N. Arnold, Mark R. Wormald, Robert B. Sim, Pauline M. Rudd, Raymond A. Dwek
Immunoglobulins are the major secretory products of the adaptive immune system. Each is characterized by a distinctive set of glycoforms that reflects the wide variation in the number, type, and location of their oligosaccharides. In a given physiological state, glycoform populations are reproducible; therefore, disease-associated alterations provide diagnostic biomarkers (e.g., for rheuma...... hiện toàn bộ
The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation
Annual Review of Immunology - Tập 10 Số 1 - Trang 645-674 - 1992
Charles A. Janeway
Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation
Annual Review of Immunology - Tập 19 Số 1 - Trang 225-252 - 2001
Benoı̂t L. Salomon, Jeffrey A. Bluestone
Recent advances in the understanding of T cell activation have led to new therapeutic approaches in the treatment of immunological disorders. One attractive target of intervention has been the blockade of T cell costimulatory pathways, which result in more selective effects on only those T cells that have encountered specific antigen. In fact, in some instances, costimulatory pathway antag...... hiện toàn bộ
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