Annual Review of Immunology

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The Regulation and Expression of c-myc in Normal and Malignant Cells
Annual Review of Immunology - Tập 4 Số 1 - Trang 317-338 - 1986
Kathleen Kelly, Ulrich Siebenlist
Making Antibodies by Phage Display Technology
Annual Review of Immunology - Tập 12 Số 1 - Trang 433-455 - 1994
Greg Winter, Andrew D. Griffiths, Robert E. Hawkins, Hennie R. Hoogenboom
Antibody fragments of predetermined binding specificity have recently been constructed from repertoires of antibody V genes, bypassing hybridoma technology and even immunization. The V gene repertoires are harvested from populations of lymphocytes, or assembled in vitro, and cloned for display of associated heavy and light chain variable domains on the surface of filamentous bacteriophage...... hiện toàn bộ
Immunobiology of Dendritic Cells
Annual Review of Immunology - Tập 18 Số 1 - Trang 767-811 - 2000
Jacques Banchereau, Francine Brière, Christophe Caux, Jean Davoust, Serge Lebecque, Yongjun Liu, Bali Pulendran, Karolina Palucka
Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary immune responses. DCs capture and transfer information from the outside world to the cells of the adaptive immune system. DCs are not only critical for the induction of primary immune responses, but may also be important for the induction of immunological tolerance, as well as for the regulation of t...... hiện toàn bộ
The Dendritic Cell System and its Role in Immunogenicity
Annual Review of Immunology - Tập 9 Số 1 - Trang 271-296 - 1991
R M Steinman
Apoptosis and Programmed Cell Death in Immunity
Annual Review of Immunology - Tập 10 Số 1 - Trang 267-293 - 1992
John Cohen, Richard C. Duke, Valerie A. Fadok, Karen S. Sellins
Death of some cells in the mammalian body is clearly programmed. In the immune system there are many examples of programmed cell death, during development of lymphocytes as well as at later stages, after interaction with antigen. Many of these examples display the morphology of apoptosis: They undergo shrinkage and zeiosis, the nucleus collapses, and chromatin is cleaved into nucleosomal ...... hiện toàn bộ
MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING
Annual Review of Immunology - Tập 16 Số 1 - Trang 323-358 - 1998
Eric G. Pamer, Peter Cresswell
▪ Abstract  Classical class I molecules assemble in the endoplasmic reticulum (ER) with peptides mostly generated from cytosolic proteins by the proteasome. The activity of the proteasome can be modulated by a variety of accessory protein complexes. A subset of the proteasome β-subunits (LMP2, LMP7, and MECL-1) and one of the accessory complexes, PA28, are upregulated by γ-interferon and a...... hiện toàn bộ
Immunology of the Maternal-Fetal Interface
Annual Review of Immunology - Tập 31 Số 1 - Trang 387-411 - 2013
Adrian Erlebacher
The immune cells that reside at the interface between the placenta and uterus are thought to play many important roles in pregnancy. Recent work has revealed that the composition and function of these cells are locally controlled by the specialized uterine stroma (the decidua) that surrounds the implanted conceptus. Here, I discuss how key immune cell types (natural killer cells, macrophag...... hiện toàn bộ
Glucocorticoids in T Cell Development and Function
Annual Review of Immunology - Tập 18 Số 1 - Trang 309-345 - 2000
Jonathan D. Ashwell, Frank W. M. Lu, Melanie S. Vacchio
Glucocorticoids are small lipophilic compounds that mediate their many biological effects by binding an intracellular receptor (GR) that, in turn, translocates to the nucleus and directly or indirectly regulates gene transcription. Perhaps the most recognized biologic effect of glucocorticoids on peripheral T cells is immunosuppression, which is due to inhibition of expression of a wide va...... hiện toàn bộ
The Cell Biology of Macrophage Activation
Annual Review of Immunology - Tập 2 Số 1 - Trang 283-318 - 1984
Dolph O. Adams, Thomas A. Hamilton
NITRIC OXIDE AND MACROPHAGE FUNCTION
Annual Review of Immunology - Tập 15 Số 1 - Trang 323-350 - 1997
John D. MacMicking, Q W Xie, Carl Nathan
▪ Abstract  At the interface between the innate and adaptive immune systems lies the high-output isoform of nitric oxide synthase (NOS2 or iNOS). This remarkable molecular machine requires at least 17 binding reactions to assemble a functional dimer. Sustained catalysis results from the ability of NOS2 to attach calmodulin without dependence on elevated Ca2+. Expressio...... hiện toàn bộ
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