Apoptosis and Programmed Cell Death in Immunity

Annual Review of Immunology - Tập 10 Số 1 - Trang 267-293 - 1992
John Cohen1, Richard C. Duke1, Valerie A. Fadok2, Karen S. Sellins3
1Department of Microbiology and Immunology, University of Colorado Medical School, Denver, Colorado 80262
2National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.
3Barbara Davis Center for Childhood Diabetes, Denver, Colorado 80262

Tóm tắt

Death of some cells in the mammalian body is clearly programmed. In the immune system there are many examples of programmed cell death, during development of lymphocytes as well as at later stages, after interaction with antigen. Many of these examples display the morphology of apoptosis: They undergo shrinkage and zeiosis, the nucleus collapses, and chromatin is cleaved into nucleosomal fragments. The cell is rapidly recognized by phagocytes and disposed of without releasing its contents. In some but not all cases of apoptosis, new macromolecular synthesis is required. Cytotoxic T cells induce changes in their targets that are morphologically apoptotic. The mechanism ofapoptosis is currently under active investigation.

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Annual Review of Immunology

Tập 10 Số 1

267-293

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