Annual Review of Immunology
SCIE-ISI SCOPUS (1983-2023)
1545-3278
0732-0582
Mỹ
Cơ quản chủ quản: Annual Reviews Inc. , ANNUAL REVIEWS
Lĩnh vực:
Immunology and AllergyImmunology
Các bài báo tiêu biểu
TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties
Tập 7 Số 1 - Trang 145-173 - 1989
Innate Immune RecognitionThe innate immune system is a universal and ancient form of host defense against infection. Innate immune recognition relies on a limited number of germline-encoded receptors. These receptors evolved to recognize conserved products of microbial metabolism produced by microbial pathogens, but not by the host. Recognition of these molecular structures allows the immune system to distinguish ... ... hiện toàn bộ
Tập 20 Số 1 - Trang 197-216 - 2002
Immunobiology of Dendritic CellsDendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary immune responses. DCs capture and transfer information from the outside world to the cells of the adaptive immune system. DCs are not only critical for the induction of primary immune responses, but may also be important for the induction of immunological tolerance, as well as for the regulation of t... ... hiện toàn bộ
Tập 18 Số 1 - Trang 767-811 - 2000
Interleukin-10 and the Interleukin-10 ReceptorInterleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types. The principal routine function of IL-10 appears to be to limit and ultimately terminate inflammatory responses. In addition to these activities, IL-10 regulates growth ... ... hiện toàn bộ
Tập 19 Số 1 - Trang 683-765 - 2001
Toll-Like ReceptorsThe innate immune system in drosophila and mammals senses the invasion of microorganisms using the family of Toll receptors, stimulation of which initiates a range of host defense mechanisms. In drosophila antimicrobial responses rely on two signaling pathways: the Toll pathway and the IMD pathway. In mammals there are at least 10 members of the Toll-like receptor (TLR) family that recogni... ... hiện toàn bộ
Tập 21 Số 1 - Trang 335-376 - 2003
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights▪ Abstract The transcription factor NF-κB has attracted widespread attention among researchers in many fields based on the following: its unusual and rapid regulation, the wide range of genes that it controls, its central role in immunological processes, the complexity of its subunits, and its apparent involvement in several diseases. A primary level of control for NF-κB is through intera... ... hiện toàn bộ
Tập 14 Số 1 - Trang 649-681 - 1996
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses▪ Abstract The transcription factor NF-κB, more than a decade after its discovery, remains an exciting and active area of study. The involvement of NF-κB in the expression of numerous cytokines and adhesion molecules has supported its role as an evolutionarily conserved coordinating element in the organism's response to situations of infection, stress, and injury. Recently, significant ad... ... hiện toàn bộ
Tập 16 Số 1 - Trang 225-260 - 1998
PD-1 and Its Ligands in Tolerance and ImmunityProgrammed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, deliver inhibitory signals that regulate the balance between T cell activation, tolerance, and immunopathology. Immune responses to foreign and self-antigens require specific and balanced responses to clear pathogens and tumors and yet maintain tolerance. Induction and maintenance of T cell tolerance requires PD-1, and its ligand ... ... hiện toàn bộ
Tập 26 Số 1 - Trang 677-704 - 2008