Innate Immune Recognition

Annual Review of Immunology - Tập 20 Số 1 - Trang 197-216 - 2002
Charles A. Janeway1, Ruslan Medzhitov1
1Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520-8011;,

Tóm tắt

The innate immune system is a universal and ancient form of host defense against infection. Innate immune recognition relies on a limited number of germline-encoded receptors. These receptors evolved to recognize conserved products of microbial metabolism produced by microbial pathogens, but not by the host. Recognition of these molecular structures allows the immune system to distinguish infectious nonself from noninfectious self. Toll-like receptors play a major role in pathogen recognition and initiation of inflammatory and immune responses. Stimulation of Toll-like receptors by microbial products leads to the activation of signaling pathways that result in the induction of antimicrobial genes and inflammatory cytokines. In addition, stimulation of Toll-like receptors triggers dendritic cell maturation and results in the induction of costimulatory molecules and increased antigen-presenting capacity. Thus, microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens.

Từ khóa


Tài liệu tham khảo

10.1101/SQB.1989.054.01.003

10.1126/science.284.5418.1313

10.1126/science.272.5258.50

10.1038/32588

10.1146/annurev.immunol.16.1.225

10.1016/0167-5699(92)90198-G

10.1016/1074-7613(95)90124-8

10.1038/29457

10.1016/S0092-8674(00)81587-1

10.1016/0092-8674(91)90165-U

10.1073/pnas.160027697

10.1016/S0952-7915(97)80152-5

10.1021/bi00135a023

Gewurz H, 1982, Adv. Intern. Med., 27, 345

10.1006/smim.1998.0141

10.4049/jimmunol.166.6.3998

Holmskov UL, 2000, APMIS Suppl., 100, 1

10.1016/S0952-7915(96)80101-4

10.1016/S0952-7915(96)80100-2

10.1084/jem.191.1.147

10.1038/386292a0

10.1146/annurev.bi.63.070194.003125

10.1016/0092-8674(95)90514-6

10.1089/jir.1997.17.503

10.1038/sj.onc.1203127

Kumar M, 1998, Microbiol. Mol. Biol. Rev., 62, 1415, 10.1128/MMBR.62.4.1415-1434.1998

10.1074/jbc.274.19.12955

10.1074/jbc.274.21.14560

10.1146/annurev.arplant.48.1.575

10.1074/jbc.M008072200

10.1074/jbc.M009728200

10.1038/35079107

10.1038/35079114

10.1146/annurev.cellbio.12.1.393

10.1016/0092-8674(88)90516-8

10.1016/S0952-7915(99)00045-X

10.1006/jmbi.1993.1392

10.1016/S0092-8674(00)80172-5

10.1073/pnas.94.26.14614

10.1016/0092-8674(93)90495-C

10.1101/gad.13.7.792

10.1016/S1074-7613(00)80208-3

10.1126/science.285.5435.1917

10.1016/S1369-5274(99)00045-4

10.1073/pnas.92.21.9465

10.1016/S1097-2765(00)80392-5

10.1101/gad.856901

10.1101/gad.817800

10.1016/S0960-9822(00)00569-8

10.1093/embo-reports/kvd073

10.1038/79801

10.1006/dbio.1998.9000

10.1016/S0092-8674(00)81466-X

10.1073/pnas.93.19.10343

10.1073/pnas.180130797

10.1093/emboj/16.20.6120

10.1038/41131

10.1126/science.282.5396.2085

10.1084/jem.189.4.615

Hoshino K, 1999, J. Immunol., 162, 3749, 10.4049/jimmunol.162.7.3749

10.1146/annurev.iy.13.040195.002253

10.4049/jimmunol.165.8.4272

10.1016/S1074-7613(00)80254-X

10.1084/jem.189.11.1777

10.1084/jem.194.1.79

10.1172/JCI8541

10.1074/jbc.M009164200

10.1073/pnas.040565397

Miyake K, 1995, J. Immunol., 154, 3333, 10.4049/jimmunol.154.7.3333

10.1182/blood.V92.8.2815

Miyake K, 1998, J. Immunol., 161, 1348, 10.4049/jimmunol.161.3.1348

10.1084/jem.192.1.23

10.1016/S1074-7613(00)80119-3

Vabulas RM, 2001, J. Biol. Chem., 11, 11

10.4049/jimmunol.164.2.558

10.1038/80833

10.1074/jbc.274.25.17406

10.1126/science.285.5428.736

10.1126/science.285.5428.732

10.4049/jimmunol.164.2.554

10.4049/jimmunol.166.1.15

10.1128/IAI.69.3.1477-1482.2001

10.1038/86354

10.4049/jimmunol.167.1.416

10.1038/44605

10.1073/pnas.250476497

10.1093/intimm/13.7.933

10.1038/35074106

10.1038/374546a0

10.1016/S0952-7915(99)00048-5

10.1038/35047123

10.1093/emboj/17.21.6230

10.1016/S0952-7915(99)80003-X

10.1016/S1097-2765(00)80136-7

10.1084/jem.187.12.2097

10.1016/S1074-7613(00)80402-1

10.1038/35014038

10.1038/383443a0

10.1016/S0092-8674(00)00126-4

10.1038/82797

10.1016/S1074-7613(00)80086-2

10.4049/jimmunol.166.9.5688

10.1016/S1074-7613(00)80596-8

10.1016/S0960-9822(00)00700-4

10.1038/ni0901-835

Schnare M, 2001, Nat. Immunol.

Means TK, 1999, J. Immunol., 163, 3920, 10.4049/jimmunol.163.7.3920

10.1073/pnas.96.25.14459

Thông tin
Thông tin xuất bản

Annual Review of Immunology

Tập 20 Số 1

197-216

Thông tin tác giả