American Journal of Reproductive Immunology
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Role of Endothelin and Inflammatory Cytokines in Pre-eclampsia - A Pilot North Indian Study
American Journal of Reproductive Immunology - Tập 65 Số 4 - Trang 428-432 - 2011
REVIEW ARTICLE: Immunology of Pre‐Eclampsia
American Journal of Reproductive Immunology - Tập 63 Số 6 - Trang 534-543 - 2010
Citation Redman CWG, Sargent IL. Immunology of Pre‐eclampsia. Am J Reprod
Immunol 2010Pre‐eclampsia develops in stages, only the last being the clinical
illness. This is generated by a non‐specific, systemic (vascular), inflammatory
response, secondary to placental oxidative stress and not by reactivity to fetal
alloantigens. However, maternal adaptation to fetal (paternal alloantigens) is
crucial...
Physiologic Adaptations of Pregnancy
American Journal of Reproductive Immunology - Tập 28 Số 3-4 - Trang 120-122 - 1992
ABSTRACT: Normal pregnancy changes include physiologic anemia, leukocytosis, and
thrombocytopenia. Cardiac rate and stroke volume increase, vascular resistance
falls, and creatinine clearance markedly rises. Thyroid binding globulin and
Cortisol binding globulin both increase, as do complement proteins and
fibrinogen, the latter resulting in a normally high erythrocyte sedimentation
rate. Estrogen...
Pregnancy Is Associated With a Reduction in the Pattern of the Cytotoxic Activity Displayed by Lymphokine‐Activated Killer Cells
American Journal of Reproductive Immunology - Tập 26 Số 4 - Trang 150-155 - 1991
ABSTRACT: Several modifications in the homeostasis of the maternal immune system
have been implicated in the survival of the fetoplacental graft. We have
investigated the adaptive response of the cytotoxic nonmajor histocompatibility
complex (MHC) ‐restricted effector lymphocytes in pregnancy, and have found that
the spontaneous lytic activity against both natural killer (NK)‐sensitive and
NK‐resi...
Mastitis and Fertility in Cattle – Possible Involvement of Inflammation or Immune Activation in Embryonic Mortality*
American Journal of Reproductive Immunology - Tập 51 Số 4 - Trang 294-301 - 2004
Causes for pre‐implantation embryo loss, which can be as high as 50% or more of
fertilized embryos, are multifactorial and largely undescribed. Studies in
cattle using mastitis as a model indicate that one cause of early embryonic loss
is infectious disease or activation of immune responses at sites outside the
reproductive tract. Infection of the mammary gland in dairy cattle is associated
with a...
Changes in T, B, and NK Lymphocyte Subsets During and After Normal Pregnancy
American Journal of Reproductive Immunology - Tập 37 Số 5 - Trang 368-377 - 1997
PROBLEM: Pregnancy affects the maternal immune system and the clinical course of
maternal diseases. Here we report the changes in the detailed lymphocyte subsets
of helper T cells, suppressor T cells, CD5+ B cells, T cell receptor (TCR)
αβ‐positive T cells (Tαβ cells), TCRαβ‐negative T cell (Tγδ cells), and others
during and after pregnancy through to one year postpartum, and discuss the
significa...
Review: Immunobiology of Preeclampsia
American Journal of Reproductive Immunology - Tập 37 Số 1 - Trang 79-86 - 1997
Preeclampsia has been recognized clinically since the time of Hippocrates:
however its etiology and pathophysiology remain enigmatic. This
pregnancy‐specific syndrome typically presents in late pregnancy as
hypertension, edema, and proteinuria. Investigations over the past 15 years have
revealed that preeclampsia is associated with abnormal placentation, reduced
placental perfusion, endothelial ce...
Evidence for an Elevation in Serum Interleukin‐2 and Tumor Necrosis Factor‐α Levels Before the Clinical Manifestations of Preeclampsia
American Journal of Reproductive Immunology - Tập 38 Số 2 - Trang 89-93 - 1997
PROBLEM: The purpose of this study is to clarify whether the disruption of
immune regulation occurs in early pregnancy before the clinical manifestations
of preeclampsia.METHOD OF STUDY: The serum concentrations of interleukin‐2
(IL‐2) and tumor necrosis factor‐α (TNF‐α) were determined by using
enzyme‐linked immunoadsorbent assay (ELISA) in the first trimester of pregnancy
in women who had preecl...
Effects of Tumor Necrosis Factor‐Alpha on Human Trophoblast Cell Adhesion and Motility
American Journal of Reproductive Immunology - Tập 36 Số 2 - Trang 65-71 - 1996
PROBLEM: Adhesive interaction between trophoblast cells and uterine endometrial
basement membrane is one of the critical processes in embryo implantation. This
interaction is directly or indirectly regulated by hormones, growth factors, and
cytokines. Since tumor necrosis factor‐alpha (TNF‐α) is synthesized by both
decidual and trophoblast cells, we hypothesized that TNF‐α may play a regulatory
ro...
Circulating Levels of Immunoreactive Cytokines in Women with Preeclampsia
American Journal of Reproductive Immunology - Tập 40 Số 2 - Trang 102-111 - 1998
PROBLEM: Circulating inflammatory cytokines have been implicated in the
pathogenesis of preeclampsia. To test this hypothesis, we measured plasma levels
of immunoreactive tumor necrosis factor (TNF)‐α and ‐β, interleukin (IL)−1α and
‐β, and IL‐6 and −10 in women with preeclampsia, in women with transient
gestational hypertension, and throughout normal pregnancy.METHOD OF STUDY:
Enzyme‐linked immun...
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