American Journal of Reproductive Immunology

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Role of Endothelin and Inflammatory Cytokines in Pre-eclampsia - A Pilot North Indian Study
American Journal of Reproductive Immunology - Tập 65 Số 4 - Trang 428-432 - 2011
Deepika Sharma, Archana Singh, Sagar Trivedi, Jayashree Bhattacharjee
REVIEW ARTICLE: Immunology of Pre‐Eclampsia
American Journal of Reproductive Immunology - Tập 63 Số 6 - Trang 534-543 - 2010
Christopher W.G. Redman, Ian L. Sargent
Citation Redman CWG, Sargent IL. Immunology of Pre‐eclampsia. Am J Reprod Immunol 2010Pre‐eclampsia develops in stages, only the last being the clinical illness. This is generated by a non‐specific, systemic (vascular), inflammatory response, secondary to placental oxidative stress and not by reactivity to fetal alloantigens. However, maternal adapt...... hiện toàn bộ
Physiologic Adaptations of Pregnancy
American Journal of Reproductive Immunology - Tập 28 Số 3-4 - Trang 120-122 - 1992
D. Ware Branch
ABSTRACT: Normal pregnancy changes include physiologic anemia, leukocytosis, and thrombocytopenia. Cardiac rate and stroke volume increase, vascular resistance falls, and creatinine clearance markedly rises. Thyroid binding globulin and Cortisol binding globulin both increase, as do complement proteins and fibrinogen, the latter resulting in a normally high erythroc...... hiện toàn bộ
Pregnancy Is Associated With a Reduction in the Pattern of the Cytotoxic Activity Displayed by Lymphokine‐Activated Killer Cells
American Journal of Reproductive Immunology - Tập 26 Số 4 - Trang 150-155 - 1991
O. Salmerón Béliz, S Vaquer, I Salmerón, Luis Moltó, P Lapeña, Luís Manzano, JUAN IGNACIO ALVAREZ DE LAS HEROS, Melchor Álvarez‐Mon
ABSTRACT: Several modifications in the homeostasis of the maternal immune system have been implicated in the survival of the fetoplacental graft. We have investigated the adaptive response of the cytotoxic nonmajor histocompatibility complex (MHC) ‐restricted effector lymphocytes in pregnancy, and have found that the spontaneous lytic activity against both natural k...... hiện toàn bộ
Mastitis and Fertility in Cattle – Possible Involvement of Inflammation or Immune Activation in Embryonic Mortality*
American Journal of Reproductive Immunology - Tập 51 Số 4 - Trang 294-301 - 2004
Peter J. Hansen, Paolete Soto, R.P. Natzke
Causes for pre‐implantation embryo loss, which can be as high as 50% or more of fertilized embryos, are multifactorial and largely undescribed. Studies in cattle using mastitis as a model indicate that one cause of early embryonic loss is infectious disease or activation of immune responses at sites outside the reproductive tract. Infection of the mammary gland in dairy cattle is associate...... hiện toàn bộ
Changes in T, B, and NK Lymphocyte Subsets During and After Normal Pregnancy
American Journal of Reproductive Immunology - Tập 37 Số 5 - Trang 368-377 - 1997
Mikio Watanabe, Yoshinori Iwatani, T Kaneda, Yoh Hidaka, Nobuaki Mitsuda, Yasuhiko Morimoto, Nobuyuki Amino
PROBLEM: Pregnancy affects the maternal immune system and the clinical course of maternal diseases. Here we report the changes in the detailed lymphocyte subsets of helper T cells, suppressor T cells, CD5+ B cells, T cell receptor (TCR) αβ‐positive T cells (Tαβ cells), TCRαβ‐negative T cell (Tγδ cells), and others during and after pregnancy through to one year postpart...... hiện toàn bộ
Review: Immunobiology of Preeclampsia
American Journal of Reproductive Immunology - Tập 37 Số 1 - Trang 79-86 - 1997
Robert N. Taylor
Preeclampsia has been recognized clinically since the time of Hippocrates: however its etiology and pathophysiology remain enigmatic. This pregnancy‐specific syndrome typically presents in late pregnancy as hypertension, edema, and proteinuria. Investigations over the past 15 years have revealed that preeclampsia is associated with abnormal placentation, reduced placental perfusion, endoth...... hiện toàn bộ
Evidence for an Elevation in Serum Interleukin‐2 and Tumor Necrosis Factor‐α Levels Before the Clinical Manifestations of Preeclampsia
American Journal of Reproductive Immunology - Tập 38 Số 2 - Trang 89-93 - 1997
Yoko Hamai, Tomoyuki Fujii, Takahiro Yamashita, Hiroshige NISHINA, Shiro Kōzuma, Yuji Mikami, Yuji Taketani
PROBLEM: The purpose of this study is to clarify whether the disruption of immune regulation occurs in early pregnancy before the clinical manifestations of preeclampsia.METHOD OF STUDY: The serum concentrations of interleukin‐2 (IL‐2) and tumor necrosis factor‐α (TNF‐α) were determined by using enzyme‐linked immunoadsorbent assay (ELISA) in the first trimester of pregnanc...... hiện toàn bộ
Circulating Levels of Immunoreactive Cytokines in Women with Preeclampsia
American Journal of Reproductive Immunology - Tập 40 Số 2 - Trang 102-111 - 1998
Kirk P. Conrad, Theresa M. Miles, Deborah Fairchild Benyo
PROBLEM: Circulating inflammatory cytokines have been implicated in the pathogenesis of preeclampsia. To test this hypothesis, we measured plasma levels of immunoreactive tumor necrosis factor (TNF)‐α and ‐β, interleukin (IL)−1α and ‐β, and IL‐6 and −10 in women with preeclampsia, in women with transient gestational hypertension, and throughout normal pregnancy.METHOD OF S...... hiện toàn bộ
Effects of Tumor Necrosis Factor‐Alpha on Human Trophoblast Cell Adhesion and Motility
American Journal of Reproductive Immunology - Tập 36 Số 2 - Trang 65-71 - 1996
Jill C. Todt, Yan Yang, Jun Lei, Michele R. Lauria, Yoram Sorokin, David B. Cotton, Frank D. Yelian
PROBLEM: Adhesive interaction between trophoblast cells and uterine endometrial basement membrane is one of the critical processes in embryo implantation. This interaction is directly or indirectly regulated by hormones, growth factors, and cytokines. Since tumor necrosis factor‐alpha (TNF‐α) is synthesized by both decidual and trophoblast cells, we hypothesized that TNF‐α may play a regul...... hiện toàn bộ
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