Evidence for an Elevation in Serum Interleukin‐2 and Tumor Necrosis Factor‐α Levels Before the Clinical Manifestations of Preeclampsia

American Journal of Reproductive Immunology - Tập 38 Số 2 - Trang 89-93 - 1997
Yoko Hamai1, Tomoyuki Fujii1, Takahiro Yamashita1, Hiroshige NISHINA1, Shiro Kōzuma1, Yuji Mikami2, Yuji Taketani1
1Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
2Department of Laboratory, Toyko University Hospital, Tokyo, Japan

Tóm tắt

PROBLEM: The purpose of this study is to clarify whether the disruption of immune regulation occurs in early pregnancy before the clinical manifestations of preeclampsia.METHOD OF STUDY: The serum concentrations of interleukin‐2 (IL‐2) and tumor necrosis factor‐α (TNF‐α) were determined by using enzyme‐linked immunoadsorbent assay (ELISA) in the first trimester of pregnancy in women who had preeclampsia develop after 28 weeks of pregnancy (preeclamptic group) and in women who completed pregnancy uneventfully (control group).RESULTS: Serum concentrations of both IL‐2 and TNF‐α in the first trimester of the preeclamptic group were significantly higher than those of the control group.CONCLUSIONS: That the perturbation of feto‐maternal immune regulation may precede the clinical manifestations of preeclampsia, which may be of relevance in the development of preeclampsia, is suggested.

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Thông tin xuất bản

American Journal of Reproductive Immunology

Tập 38 Số 2

89-93

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