American Journal of Physiology - Regulatory Integrative and Comparative Physiology

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Relationships between aerobic and anaerobic energy production in turtle brain in situ
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 247 Số 4 - Trang R740-R744 - 1984
Peter L. Lutz, P. M. McMahon, Myron Rosenthal, Thomas J. Sick
To define the relationships between brain mitochondrial activity and high-energy intermediates in the turtle, brains were frozen in situ at times determined by the reduction-oxidation status of cytochrome a,a3. Increases in brain lactate indicated that transition to anaerobiosis occurred while oxidative reactions were still ongoing during hypoxia and that the signal for anaerobiosis is no...... hiện toàn bộ
Highly sensitive index of sympathetic activity based on time-frequency spectral analysis of electrodermal activity
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 311 Số 3 - Trang R582-R591 - 2016
Hugo F. Posada-Quintero, John P. Florian, Álvaro D. Orjuela-Cañón, Ki H. Chon
Time-domain indices of electrodermal activity (EDA) have been used as a marker of sympathetic tone. However, they often show high variation between subjects and low consistency, which has precluded their general use as a marker of sympathetic tone. To examine whether power spectral density analysis of EDA can provide more consistent results, we recently performed a variety of sympathetic ...... hiện toàn bộ
The molecular basis of aerobic metabolic remodeling differs between oxidative muscle and liver of threespine sticklebacks in response to cold acclimation
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 299 Số 1 - Trang R352-R364 - 2010
Julieanna I. Orczewska, Götz Hartleben, Kristin M. O’Brien
We sought to determine the molecular basis of elevations in aerobic metabolic capacity in the oxidative muscle and liver of Gasterosteus aculeatus in response to cold acclimation. Fishes were cold- or warm-acclimated for 9 wk and harvested on days 1, 2, and 3 and weeks 1, 4, and 9 of cold acclimation at 8°C, and on day 1 and week 9 of warm acclimation at 20°C. Mitochondrial volume density ...... hiện toàn bộ
Seasonal changes in serum leptin, food intake, and body weight in photoentrained woodchucks
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 281 Số 3 - Trang R951-R959 - 2001
Patrick W. Concannon, K.D. Levac, Richard E. Rawson, Bud C. Tennant, André Bensadoun
Male woodchucks ( Marmota monax) were maintained in northern vs. southern hemisphere photoperiods, provided feed and water ad libitum, and evaluated every 2 wk for 23 mo for body weight, absolute and relative food intake, body temperature, serum testosterone, and serum concentrations of leptin measured using an anti-mouse leptin enzyme-linked immunoassay. During late spring and summer, bod...... hiện toàn bộ
Metabolic control of food intake and estrous cycles in Syrian hamsters. I. Plasma insulin and leptin
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 278 Số 2 - Trang R476-R485 - 2000
Jill E. Schneider, Robert M. Blum, George N. Wade
The “adipostat hypothesis” refers to the idea that circulating hormone concentrations reflect levels of body adiposity and act as signals to control food intake and reproduction. Implicit in the adipostatic hypothesis are the following two assumptions: 1) plasma levels of adipostatic hormones accurately reflect body fat content and 2) decreased plasma concentrations of adipostatic hormones...... hiện toàn bộ
Intradermal administration of ATP does not mitigate tyramine-stimulated vasoconstriction in human skin
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 298 Số 5 - Trang R1417-R1420 - 2010
Jonathan E. Wingo, R. Matthew Brothers, Juan Del Coso, Craig G. Crandall
Cutaneous vasodilation associated with whole-body heat stress occurs via withdrawal of adrenergic vasoconstriction and engagement of cholinergic “active” vasodilation, the latter of which attenuates cutaneous vasoconstrictor responsiveness. However, the precise neurotransmitter(s) responsible for this sympatholytic-like effect remain unknown. In skeletal muscle, ATP inhibits adrenergicall...... hiện toàn bộ
Separate and combined effects of KCa and KATP channel blockade with NOS inhibition on cutaneous vasodilation and sweating in older men during heat stress
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 317 Số 1 - Trang R113-R120 - 2019
Gregory W. McGarr, Naoto Fujii, Caroline M. Muia, Takeshi Nishiyasu, Glen P. Kenny
Our objective in this study was to examine the separate and combined effects of potassium (K+) channels and nitric oxide synthase (NOS) on cutaneous vasodilation and sweating in older men during rest and exercise in the heat. In 13 habitually active men (61 ± 4 yr), cutaneous vascular conductance and local sweat rate were assessed at six dorsal forearm skin sites cont...... hiện toàn bộ
Healthy active older adults have enhanced K+channel-dependent endothelial vasodilatory mechanisms
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 319 Số 1 - Trang R19-R25 - 2020
Corinna Serviente, Craig W. Berry, W. Larry Kenney, Lacy M. Alexander
Microvascular endothelial dysfunction, a precursor to atherosclerotic cardiovascular disease, increases with aging. Endothelium-derived hyperpolarizing factors (EDHFs), which act through K+channels, regulate blood flow and are important to vascular health. It is unclear how EDHFs change with healthy aging. To evaluate microvascular endothelial reliance on K+<...... hiện toàn bộ
Reduced central leptin sensitivity in rats with diet-induced obesity
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 283 Số 4 - Trang R941-R948 - 2002
Barry E. Levin, Ambrose A. Dunn-Meynell
On low-fat chow diet, rats prone to diet-induced obesity (DIO) have increased arcuate nucleus neuropeptide Y (NPY) expression but similar leptin levels compared with diet-resistant (DR) rats (19). Here, body weight and leptin levels rose in DIO rats, and they defended their higher body weight after only 1 wk on a 31% fat high-energy (HE) diet. However, DIO NPY expression did not fall to DR...... hiện toàn bộ
Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 289 Số 5 - Trang R1392-R1399 - 2005
Ana Navarro, Carmen Gómez, María-Jesús Sánchez-Pino, Hipolito J. Gonzalez, Manuel J. Bández, Alberto Boveris, Alberto Boveris
Male mice receiving vitamin E (5.0 g α-tocopherol acetate/kg of food) from 28 wk of age showed a 40% increased median life span, from 61 ± 4 wk to 85 ± 4 wk, and 17% increased maximal life span, whereas female mice equally supplemented exhibited only 14% increased median life span. The α-tocopherol content of brain and liver was 2.5-times and 7-times increased in male mice, respectively. V...... hiện toàn bộ
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