American Journal of Physiology - Regulatory Integrative and Comparative Physiology

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Dynamic resetting of the human circadian pacemaker by intermittent bright light
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 279 Số 5 - Trang R1574-R1579 - 2000
David W. Rimmer, Diane B. Boivin, Theresa L. Shanahan, Richard E. Kronauer, Jeanne F. Duffy, Charles A. Czeisler
In humans, experimental studies of circadian resetting typically have been limited to lengthy episodes of exposure to continuous bright light. To evaluate the time course of the human endogenous circadian pacemaker's resetting response to brief episodes of intermittent bright light, we studied 16 subjects assigned to one of two intermittent lighting conditions in which the subjects were presented ... hiện toàn bộ
Simulations of light effects on the human circadian pacemaker: implications for assessment of intrinsic period
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 270 Số 1 - Trang R271-R282 - 1996
Elizabeth B. Klerman, Derk‐Jan Dijk, Richard E. Kronauer, Charles A. Czeisler
The sensitivity of the human circadian system to light has been the subject of considerable debate. Using computer simulations of a recent quantitative model for the effects of light on the human circadian system, we investigated these effects of light during different experimental protocols. The results of the simulations indicate that the nonuniform distribution over the circadian cycle of expos... hiện toàn bộ
Comparative analysis of expression and secretion of placental leptin in mammals
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 285 Số 2 - Trang R438-R446 - 2003
Jing Zhao, Thomas Kunz, Nancy Tumba, Laura C. Schulz, Chris Li, Monica Reeves, Eric P. Widmaier
Increased plasma level of leptin appears to be a ubiquitous feature of pregnant mammals. The mechanisms by which leptin levels are increased may be species specific, however, with some species upregulating adipose leptin production and others expressing leptin in the placenta. Placental leptin expression was examined in representative species of the two most abundant mammalian orders, Rodentia and... hiện toàn bộ
Inflammatory processes in muscle injury and repair
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 288 Số 2 - Trang R345-R353 - 2005
James G. Tidball
Modified muscle use or injury can produce a stereotypic inflammatory response in which neutrophils rapidly invade, followed by macrophages. This inflammatory response coincides with muscle repair, regeneration, and growth, which involve activation and proliferation of satellite cells, followed by their terminal differentiation. Recent investigations have begun to explore the relationship between i... hiện toàn bộ
Sex differences in the developmental origins of hypertension and cardiorenal disease
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 295 Số 6 - Trang R1941-R1952 - 2008
Jeffrey S. Gilbert, Mark J. Nijland
The “developmental origins of health and disease” (DOHAD) hypothesis derives from clinical observations, indicating long-term health consequences for persons of low birth weight. There is growing evidence, primarily from animal studies, that supports the idea that processes put in motion during development that contribute to DOHAD do not necessarily reflect as significantly compromised growth and ... hiện toàn bộ
Quercetin tăng cường sinh tổng hợp ty thể não và cơ bắp cũng như khả năng chịu đựng trong tập luyện Dịch bởi AI
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 296 Số 4 - Trang R1071-R1077 - 2009
John M. Davis, E. Angela Murphy, Martin D. Carmichael, Ben Davis
Quercetin là một trong những nhóm lớn các hợp chất flavonoid polyphenolic tự nhiên đang được nghiên cứu vì những lợi ích sức khỏe rộng rãi của chúng. Những lợi ích này thường được cho là do sự kết hợp của hoạt động chống oxy hóa và kháng viêm, nhưng các bằng chứng in vitro gần đây cho thấy rằng sự cải thiện sinh tổng hợp ty thể có thể đóng một vai trò quan trọng. Hơn nữa, các tác động in vivo của ... hiện toàn bộ
Relationships between aerobic and anaerobic energy production in turtle brain in situ
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 247 Số 4 - Trang R740-R744 - 1984
Peter L. Lutz, P. M. McMahon, Myron Rosenthal, Thomas J. Sick
To define the relationships between brain mitochondrial activity and high-energy intermediates in the turtle, brains were frozen in situ at times determined by the reduction-oxidation status of cytochrome a,a3. Increases in brain lactate indicated that transition to anaerobiosis occurred while oxidative reactions were still ongoing during hypoxia and that the signal for anaerobiosis is not the com... hiện toàn bộ
Highly sensitive index of sympathetic activity based on time-frequency spectral analysis of electrodermal activity
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 311 Số 3 - Trang R582-R591 - 2016
Hugo F. Posada-Quintero, John P. Florian, Álvaro D. Orjuela-Cañón, Ki H. Chon
Time-domain indices of electrodermal activity (EDA) have been used as a marker of sympathetic tone. However, they often show high variation between subjects and low consistency, which has precluded their general use as a marker of sympathetic tone. To examine whether power spectral density analysis of EDA can provide more consistent results, we recently performed a variety of sympathetic tone-evok... hiện toàn bộ
The molecular basis of aerobic metabolic remodeling differs between oxidative muscle and liver of threespine sticklebacks in response to cold acclimation
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 299 Số 1 - Trang R352-R364 - 2010
Julieanna I. Orczewska, Götz Hartleben, Kristin M. O’Brien
We sought to determine the molecular basis of elevations in aerobic metabolic capacity in the oxidative muscle and liver of Gasterosteus aculeatus in response to cold acclimation. Fishes were cold- or warm-acclimated for 9 wk and harvested on days 1, 2, and 3 and weeks 1, 4, and 9 of cold acclimation at 8°C, and on day 1 and week 9 of warm acclimation at 20°C. Mitochondrial volume density was quan... hiện toàn bộ
Substance P in the nucleus of the solitary tract augments bronchopulmonary C fiber reflex output
American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 279 Số 4 - Trang R1215-R1223 - 2000
Tatsushi Mutoh, Ann C. Bonham, Jesse P. Joad
Bronchopulmonary C fibers defend the lungs against injury from inhaled agents by a central nervous system reflex consisting of apnea, cough, bronchoconstriction, hypotension, and bradycardia. Glutamate is the putative neurotransmitter at the first central synapses in the nucleus of the solitary tract (NTS), but substance P, also released in the NTS, may modulate the transmission. To test the hypot... hiện toàn bộ
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