Substance P in the nucleus of the solitary tract augments bronchopulmonary C fiber reflex output

American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 279 Số 4 - Trang R1215-R1223 - 2000
Tatsushi Mutoh1,2, Ann C. Bonham2, Jesse P. Joad1
1Department of Pediatrics, University of California, Davis, Sacramento, California 95616
2Departments of Internal Medicine and Pharmacology and

Tóm tắt

Bronchopulmonary C fibers defend the lungs against injury from inhaled agents by a central nervous system reflex consisting of apnea, cough, bronchoconstriction, hypotension, and bradycardia. Glutamate is the putative neurotransmitter at the first central synapses in the nucleus of the solitary tract (NTS), but substance P, also released in the NTS, may modulate the transmission. To test the hypothesis that substance P in the NTS augments bronchopulmonary C fiber input and hence reflex output, we stimulated the C fibers with left atrial capsaicin (LA CAP) injections and compared the changes in phrenic nerve discharge, tracheal pressure (TP), arterial blood pressure (ABP), and heart rate (HR) in guinea pigs before and after substance P injections (200 μM, 25 nl) in the NTS. Substance P significantly augmented LA CAP-evoked increases in expiratory time by 10-fold and increases in TP and decreases in ABP and HR by threefold, effects prevented by neurokinin-1 (NK1) receptor antagonism. Thus substance P acting at NTS NK1 receptors can exaggerate bronchopulmonary C fiber reflex output. Because substance P synthesis in vagal airway C fibers may be enhanced in pathological conditions such as allergic asthma, the findings may help explain some of the associated respiratory symptoms including cough and bronchoconstriction.

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American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Tập 279 Số 4

R1215-R1223

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