Dynamic resetting of the human circadian pacemaker by intermittent bright light

American Journal of Physiology - Regulatory Integrative and Comparative Physiology - Tập 279 Số 5 - Trang R1574-R1579 - 2000
David W. Rimmer1, Diane B. Boivin1, Theresa L. Shanahan1, Richard E. Kronauer2, Jeanne F. Duffy1, Charles A. Czeisler1
1Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston 02115; and
2Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachussets 02138

Tóm tắt

In humans, experimental studies of circadian resetting typically have been limited to lengthy episodes of exposure to continuous bright light. To evaluate the time course of the human endogenous circadian pacemaker's resetting response to brief episodes of intermittent bright light, we studied 16 subjects assigned to one of two intermittent lighting conditions in which the subjects were presented with intermittent episodes of bright-light exposure at 25- or 90-min intervals. The effective duration of bright-light exposure was 31% or 63% compared with a continuous 5-h bright-light stimulus. Exposure to intermittent bright light elicited almost as great a resetting response compared with 5 h of continuous bright light. We conclude that exposure to intermittent bright light produces robust phase shifts of the endogenous circadian pacemaker. Furthermore, these results demonstrate that humans, like other species, exhibit an enhanced sensitivity to the initial minutes of bright-light exposure.

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American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Tập 279 Số 5

R1574-R1579

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