American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

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Association study of the adrenergic receptors and childhood‐onset mood disorders in Hungarian families
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 141B Số 3 - Trang 227-233 - 2006
Irina Burcescu, Karen G. Wigg, Lissette Gomez, Nicole King, Ágnes Vetró, É Kiss, Krisztina Kapornai, Júlia Gádoros, James L. Kennedy, Mária Kovács, Cathy L. Barr
AbstractThe adrenergic system has been implicated in the etiology of depression based on a number of lines of evidence, particularly, the mechanism of some classes of antidepressants which increase the synaptic levels of norepinephrine. Further, several genome scans for mood disorders, both unipolar and bipolar, have indicated linkage to the chromosomal regions of 5q23–q33.3, 8p12–p11.2, 4p16, and... hiện toàn bộ
An examination of the behavioral and neuropsychological correlates of three ADHD candidate gene polymorphisms (DRD4 7+, DBH TaqI A2, and DAT1 40 bp VNTR) in hyperactive and normal children followed to adulthood
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 141B Số 5 - Trang 487-498 - 2006
Russell A. Barkley, Karen Smith, Mariellen Fischer, Bradford Navia
AbstractSeveral candidate gene polymorphisms have been implicated in attention deficit hyperactivity disorder (ADHD), including DAT1 40bp VNTR, DRD4 7+, and DBH TaqI A2 alleles. We used the Milwaukee longitudinal study of hyperactive (n = 122) and normal (n = 67) children to compare participants with and without these respective polymorphisms on ADHD‐related behavioral ratings at childhood, 8 year... hiện toàn bộ
Association between the dopamine receptor D4 (DRD4) gene and obsessive‐compulsive disorder
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 116B Số 1 - Trang 55-59 - 2003
Bruno Millet, Nadia Chabane, Richard Delorme, Marion Leboyer, Sophie Leroy, Marie‐France Poirier, Marie‐Chantal Bourdel, Marie‐Christine Mouren‐Siméoni, Frédéric Rouillon, Henri Lôo, Marie‐Odile Krebs
AbstractObsessive‐compulsive disorder (OCD) is a frequent and disabling anxiety disorder. Dopamine (DA) might be involved in its pathophysiology, therefore DA receptors are candidate genes in OCD. A 48‐base pairs (bp) polymorphism located in the third exon of the dopamine receptor type 4 (DRD4) gene has been described. Previous case control studies, however, have reported inconclusive results in O... hiện toàn bộ
Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 144B Số 3 - Trang 271-278 - 2007
Xiangdong Deng, Hiroki Shibata, Naoko Takeuchi, Shinako Rachi, Mayumi Sakai, Hideaki Ninomiya, Nakao Iwata, Norio Ozaki, Yasuyuki Fukumaki
AbstractBased on the glutamatergic dysfunction hypothesis for schizophrenia pathogenesis, we have been performing systematic association studies of schizophrenia with the glutamate receptor and transporter genes. We report here association studies of schizophrenia with three glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 encoding the glutamate transporters EAAT3, EAAT1, and EAAT4, respecti... hiện toàn bộ
Dopaminergic mutations: Within‐family association and linkage in multiplex alcohol dependence families
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 147B Số 4 - Trang 517-526 - 2008
Shirley Y. Hill, Eric K. Hoffman, Nicholas Zezza, Anbupalam Thalamuthu, Daniel E. Weeks, Abigail Matthews, Indranil Mukhopadhyay
AbstractAnimal and human studies of addiction indicate that the D2 dopamine receptor (DRD2) plays a critical role in the mechanism of drug reward. D2 receptor density in the brains of alcoholics has been shown to be reduced relative to controls. Previous studies of DRD2 in association with alcohol dependence using variation in the TaqI A locus were highly controversial. Recently, a synonymous muta... hiện toàn bộ
Association study of CREB1 with Major Depressive Disorder and related phenotypes
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 150B Số 8 - Trang 1128-1132 - 2009
John M. Hettema, Seon‐Sook An, Edwin J. C. G. van den Oord, Michael C. Neale, Kenneth S. Kendler, Xiangning Chen
AbstractCyclic AMP response element binding protein (CREB) has been implicated in behavioral models of anxiety and depression, antidepressant response in humans, and suicide. One group reported a female‐specific association of the CREB1 gene in early‐onset Major Depressive Disorder (MDD), while another found no evidence of association with this phenotype. In this study, we sought to examine the ev... hiện toàn bộ
A meta‐analysis of association studies between the 10‐repeat allele of a VNTR polymorphism in the 3′‐UTR of dopamine transporter gene and attention deficit hyperactivity disorder
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 144B Số 4 - Trang 541-550 - 2007
Binrang Yang, Raymond C. K. Chan, Jing Jin, Tao Li, Pak C. Sham, Ronald Y.L. Chen
AbstractThe association between the 10‐repeat allele of the dopamine transporter gene (DAT) and attention deficit hyperactivity disorder (ADHD) is uncertain. This study aimed to conduct a meta‐analysis of the association between the 10‐repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3′‐untranslated region (UTR) of the DAT1 gene and ADHD. We pooled up 18 published transm... hiện toàn bộ
Study of MECP2 gene in Rett syndrome variants and autistic girls
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 119B Số 1 - Trang 102-107 - 2003
Michele Zappella, Ilaria Meloni, Ilaria Longo, Roberto Canitano, Joussef Hayek, Lucia Rosaia, Francesca Mari, Alessandra Renieri
AbstractMutations in MECP2 gene account for approximately 80% of cases of Rett syndrome (RTT), an X‐linked severe developmental disorder affecting young girls, as well as for most cases of Preserved Speech Variant (PSV), a mild RTT variant in which autistic behavior is common. The aim of this study is to determine whether MECP2 mutations are responsible for PSV only or may cause other forms of aut... hiện toàn bộ
Relationship between dopaminergic neurotransmission, alcoholism, and reward deficiency syndrome
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 132B Số 1 - Trang 29-37 - 2005
Abdalla Bowirrat, Marlene Oscar‐Berman
AbstractIn this review, we described the neural substrates underlying Reward Deficiency syndrome which, in turn, is posited to underlie alcohol dependency. Alcoholism is a complex, multifactorial disorder that results from the interplay between genetic and environmental factors. The D2 dopamine receptor (DRD2) has been associated with pleasure, and the DRD2 A1 allele has been referred to as a rewa... hiện toàn bộ
Association between serotonin transporter gene polymorphism and eating disorders outcome: A 6‐year follow‐up study
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 159B Số 5 - Trang 491-500 - 2012
Giovanni Castellini, Valdo Ricca, Lorenzo Lelli, Silvia Bagnoli, Ersilia Lucenteforte, Carlo Faravelli, Sandro Sorbi, Benedetta Nacmias
AbstractEating disorder patients show different long‐term outcomes, and trait‐related alterations of serotonergic function, which might be related with the serotonin transporter (5‐HTT) gene. We studied the relationships between 5‐HTTLPR polymorphism, eating specific and general psychopathology and the long‐term outcome of anorexia nervosa (AN) and bulimia nervosa (BN) patients. We evaluated the d... hiện toàn bộ
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