Association between the dopamine receptor D4 (DRD4) gene and obsessive‐compulsive disorder

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 116B Số 1 - Trang 55-59 - 2003
Bruno Millet1, Nadia Chabane2, Richard Delorme3, Marion Leboyer3, Sophie Leroy1, Marie‐France Poirier1, Marie‐Chantal Bourdel1, Marie‐Christine Mouren‐Siméoni2, Frédéric Rouillon3, Henri Lôo1, Marie‐Odile Krebs1
1INSERM E0117 Paris V, University Department of Psychiatry, Sainte‐Anne Hospital, Paris, France
2Psychiatric Department of Child Psychiatry, AP‐HP, Hôpital Robert Debré, Paris, France
3Hôpital Albert Chenevier et Henri Mondor, Department of Psychiatry, AP‐HP, Créteil, France

Tóm tắt

AbstractObsessive‐compulsive disorder (OCD) is a frequent and disabling anxiety disorder. Dopamine (DA) might be involved in its pathophysiology, therefore DA receptors are candidate genes in OCD. A 48‐base pairs (bp) polymorphism located in the third exon of the dopamine receptor type 4 (DRD4) gene has been described. Previous case control studies, however, have reported inconclusive results in OCD. The aim of the study was to study this polymorphism in a family‐based association study of 55 trios. Extended transmission‐disequilibrium test (ETDT) for preferential allele transmission in this group showed an absence of transmission of the allele 2 for the 48 bp repeat polymorphism of the DRD4 gene (P = 0.005). Moreover, in a population‐based association study, we found a significantly lower frequency of the allele 2 in patients suffering from OCD compared to ethnically‐matched controls (P = 0.02). We found no association of DRD4 48 bp polymorphism with OCD in the subgroup of patients with comorbid tics. This study is the first to report on a significant association of variants of the DRD4 gene in OCD, found on both family‐ and population‐based studies. The results suggest that the 2 allele or a nearby genetic variation could have a protective effect against OCD symptoms. © 2003 Wiley‐Liss, Inc.

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American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Tập 116B Số 1

55-59

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