American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
SCIE-ISI SCOPUS (1993,1995-2023)
1552-4841
1552-485X
Mỹ
Cơ quản chủ quản: WILEY , Wiley-Liss Inc.
Lĩnh vực:
Cellular and Molecular NeurosciencePsychiatry and Mental HealthGenetics (clinical)
Các bài báo tiêu biểu
Relationship between dopaminergic neurotransmission, alcoholism, and reward deficiency syndromeAbstract In this review, we described the neural substrates underlying Reward Deficiency syndrome which, in turn, is posited to underlie alcohol dependency. Alcoholism is a complex, multifactorial disorder that results from the interplay between genetic and environmental factors. The D2 dopamine receptor (DRD2 ) has been asso... ...
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Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephalyAbstract Mutations in the PTEN gene are associated with a broad spectrum of disorders, including Cowden syndrome (CS), Bannayan–Riley–Ruvalcaba syndrome, Proteus syndrome, and Lhermitte–Duclos disease. In addition, PTEN mutations have been described in a few patients with autism spectrum disorders (ASDs) and macr... ...
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Assessing the validity of blood‐based gene expression profiles for the classification of schizophrenia and bipolar disorder: A preliminary reportAbstract Recent advances have facilitated the use of blood‐derived RNA to conduct genomic analyses of human diseases. This emerging technology represents a rigorous and convenient alternative to traditional tissue biopsy‐derived RNA, as it allows for larger sample sizes, better standardization of technical procedures, and the ability to non‐invasively profile human ... ...
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Understanding comorbidity: A twin study of reading disability and attention‐deficit/hyperactivity disorderAbstract A community sample of twins in which at least one member of each pair exhibited significant reading difficulties (99 monozygotic and 80 dizygotic pairs) or symptoms of attention‐deficit/hyperactivity disorder (ADHD; 83 monozygotic and 78 dizygotic pairs) was used to test the etiology of comorbidity between reading disability (RD) and ADHD. Univariate analys... ...
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A meta‐analysis of association studies between the 10‐repeat allele of a VNTR polymorphism in the 3′‐UTR of dopamine transporter gene and attention deficit hyperactivity disorderAbstract The association between the 10‐repeat allele of the dopamine transporter gene (DAT ) and attention deficit hyperactivity disorder (ADHD) is uncertain. This study aimed to conduct a meta‐analysis of the association between the 10‐repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3′‐untranslated region (UTR)... ...
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Obsessive‐compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndromeAbstract Obsessive‐compulsive disorder (OCD) is an etiologically heterogeneous disorder. Recent factor analyses have consistently identified several symptom dimensions, two of which are associated with increased familial risk for OCD; aggressive, sexual, and religious obsessions and checking compulsions (FACTOR 1) and symmetry and ordering obsessions and compulsions... ...
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A linkage disequilibrium map of the 1‐Mb 15q12 GABAA receptor subunit cluster and association to autismAbstract Autism is a complex genetic neuropsychiatric condition characterized by deficits in social interaction and language and patterns of repetitive or stereotyped behaviors and restricted interests. Chromosome 15q11.2‐q13 is a candidate region for autism susceptibility based on observations of chromosomal duplications in a small percentage of affected individual... ...
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Confirming RGS4 as a susceptibility gene for schizophreniaAbstract A recent study identified a putative association between variants in the regulator of G‐protein signalling 4 (RGS4) and schizophrenia, Chowdari et al. [2002: Hum Mol Genet 11: 1373–1380]. RGS4 is both a positional and functional candidate gene for schizophrenia. Chowdari and colleagues identified association at this locus in a num... ...
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Morbid risk for psychiatric disorder among the relatives of methamphetamine users with and without psychosis
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