Obsessive‐compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 116B Số 1 - Trang 60-68 - 2003
James F. Leckman1, David L. Pauls2, Heping Zhang3,1, Maria Conceição do Rosário1, Liliya Katsovich1, Kenneth K. Kídd4, A.J. Pakstis4, John P. Alsobrook5, Veit Roessner6, William M. McMahon7, John T. Walkup8, B.J.M. van de Wetering9, Robert A. King1, Donald J. Cohen1
1Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut
2Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts
3Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut
4Department of Genetics, Yale University School of Medicine, New Haven, Connecticut
5CuraGen Corporation, Branford, Connecticut
6Department of Psychiatry and Behavioral Sciences, University College and the National Hospital for Neurology and Neurosurgery, Queen Square, London
7Departments of Human Genetics and Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah
8Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland
9Department of Psychiatry, Erasmus University Rotterdam, The Netherlands

Tóm tắt

AbstractObsessive‐compulsive disorder (OCD) is an etiologically heterogeneous disorder. Recent factor analyses have consistently identified several symptom dimensions, two of which are associated with increased familial risk for OCD; aggressive, sexual, and religious obsessions and checking compulsions (FACTOR 1) and symmetry and ordering obsessions and compulsions (FACTOR 2). Both of these symptom dimensions are also frequently seen in association with Gilles de la Tourette syndrome (GTS). The purpose of this study was to determine whether these obsessive‐compulsive (OC) symptom dimensions are correlated within families (between sibs and between parent‐child pairs). Using data collected by the Tourette Syndrome Association International Consortium for Genetics Affected Sibling Pair Study, the authors selected all available GTS sib pairs and their parents for which these OC symptom dimensions (factor scores) could be generated. This group included 128 full sibs and their mothers (54) and fathers (54). Four OC symptom dimension scores were computed for each family member using an algorithm derived from item endorsements from the Yale‐Brown Obsessive‐Compulsive Scale (Y‐BOCS) symptom checklist. In addition to a series of univariate analyses, complex segregation analyses were also completed using these quantitative OC symptom dimension scores. FACTOR 1 and FACTOR 2 scores were significantly correlated in sib pairs concordant for GTS. The mother–child correlations, but not father–child correlations, were also significant for these two factors. Segregation analyses were consistent with dominant major gene effects for both FACTOR 1 and FACTOR 2. We conclude that familial factors contribute significantly to OC symptom dimension phenotypes in GTS families. This familial contribution could be genetic or environmental. © 2003 Wiley‐Liss, Inc.

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American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Tập 116B Số 1

60-68

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