Association between serotonin transporter gene polymorphism and eating disorders outcome: A 6‐year follow‐up study

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 159B Số 5 - Trang 491-500 - 2012
Giovanni Castellini1, Valdo Ricca1, Lorenzo Lelli1, Silvia Bagnoli1, Ersilia Lucenteforte2, Carlo Faravelli3, Sandro Sorbi1, Benedetta Nacmias1
1Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla, Florence, Italy
2Department of Preclinical and Clinical Pharmacology "M. Aiazzi Mancini", Centre for Molecular Medicine (CIMMBA), University of Florence, Viale G. Pieraccini, Florence, Italy
3Department of Psychology, University of Florence, Via San Niccolò, Florence, Italy

Tóm tắt

AbstractEating disorder patients show different long‐term outcomes, and trait‐related alterations of serotonergic function, which might be related with the serotonin transporter (5‐HTT) gene. We studied the relationships between 5‐HTTLPR polymorphism, eating specific and general psychopathology and the long‐term outcome of anorexia nervosa (AN) and bulimia nervosa (BN) patients. We evaluated the distribution of the functional 5‐HTTLPR polymorphism in a series of 201 Italian, Caucasian, eating disorder patients (113 with AN and 88 with BN binge/purging (BP subtype) and in 150 Caucasian unrelated controls. Prior to starting an individual cognitive behavior therapy, a clinical assessment was performed by means of the structured clinical interview for DSM‐IV axis I disorders and several self‐report questionnaires. This assessment was repeated at the end of treatment, 3 years after the end of treatment and 3 years after the first follow‐up. Diagnostic changes between AN and BN were frequent (28.3%), and the presence of depressive disorders was associated with a higher rate of diagnostic crossover during the follow‐up period. The S‐allele of the 5‐HTTLPR genotype increases the risk susceptibility for both depressive comorbidity (OR = 4.23; 95% CI, 1.45–12.37) and diagnostic crossover during the follow‐up period in AN patients (OR = 5.04; 95% CI, 1.69–14.98). Logistic regression analyses confirmed these findings, when the interaction between genotype and psychiatric comorbidity as predictors of diagnostic instability in AN patients were taken into account. No significant association was found between 5‐HTTLPR genotype and recovery. The S‐allele of the 5‐HTTLPR genotype increases the risk for depressive disorders comorbidity, and moderates the long‐term outcome of anorectic patients. © 2012 Wiley Periodicals, Inc.

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American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Tập 159B Số 5

491-500

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