Association study of CREB1 with Major Depressive Disorder and related phenotypes

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics - Tập 150B Số 8 - Trang 1128-1132 - 2009
John M. Hettema1, Seon‐Sook An1, Edwin J. C. G. van den Oord2,1, Michael C. Neale3,1, Kenneth S. Kendler3,1, Xiangning Chen1
1Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia
2Department of Pharmacy, Center for Biomarker Research and Personalized Medicine, Virginia Commonwealth University, Richmond, Virginia.
3Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia

Tóm tắt

AbstractCyclic AMP response element binding protein (CREB) has been implicated in behavioral models of anxiety and depression, antidepressant response in humans, and suicide. One group reported a female‐specific association of the CREB1 gene in early‐onset Major Depressive Disorder (MDD), while another found no evidence of association with this phenotype. In this study, we sought to examine the evidence for association of the CREB1 gene to MDD and related phenotypes. We used multivariate structural equation modeling to identify and select twin pairs that scored at the extremes of a latent genetic risk factor shared by MDD, neuroticism, and several anxiety disorders from the Virginia Twin Registry. Using one member from each of these pairs, the resulting sample of 589 cases (including 473 subjects with lifetime MDD) and 539 controls were entered into a 2‐stage association study in which genetic markers were screened in stage 1, the positive results of which were tested for replication in stage 2. Eight SNP markers selected to capture the major allelic variation across the haplotype block containing CREB1 were analyzed for differences between cases and controls. Several markers showed criterion differences between cases and controls in the stage 1 sample with some evidence of sex specific effects. However, none of these markers were significant in stage 2 in either sex individually or combined. Our data suggests that common variations in the CREB1 gene do not appear to increase susceptibility for MDD or related phenotypes. © 2009 Wiley‐Liss, Inc.

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American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Tập 150B Số 8

1128-1132

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