American Association for the Advancement of Science (AAAS)

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Total-body imaging: Transforming the role of positron emission tomography
American Association for the Advancement of Science (AAAS) - Tập 9 Số 381 - 2017
Simon R. Cherry, Ramsey D. Badawi, Joel S. Karp, W.W. Moses, Pat Price, Terry Jones
The first total-body positron emission tomography (TB-PET) scanner represents a radical change for experimental medicine and diagnostic health care.
Predicting functional effects of missense variants in voltage-gated sodium and calcium channels
American Association for the Advancement of Science (AAAS) - Tập 12 Số 556 - 2020
Henrike Heyne, David Báez-Nieto, Sumaiya Iqbal, Duncan S. Palmer, Andreas Brunklaus, Patrick May, Katrine M. Johannesen, Stephan Lauxmann, Johannes R. Lemke, Rikke S. Møller, Eduardo Pérez‐Palma, Ute I. Scholl, Steffen Syrbe, Holger Lerche, Dennis Lal, Arthur J. Campbell, Hao-Ran Wang, Jen Q. Pan, Mark J. Daly
A machine learning method can predict loss- versus gain-of-function effects of human genetic variants in disease-associated ion channels.
PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function
American Association for the Advancement of Science (AAAS) - Tập 4 Số 142 - 2012
Taiji Tsunemi, Travis D. Ashe, Brad E. Morrison, Kathryn Soriano, Jonathan Au, Rubén Antonio Vázquez‐Roque, Eduardo R. Lazarowski, Vincent A. Damian, Eliezer Masliah, Albert R. La Spada
PGC-1α rescues Huntington’s disease neurodegeneration by reducing reactive oxygen species and inducing a master regulator of autophagy.
Rapamycin and Alzheimer’s disease: Time for a clinical trial?
American Association for the Advancement of Science (AAAS) - Tập 11 Số 476 - 2019
Matt Kaeberlein, Verónica Galván
In this Perspective, the authors propose that clinical testing of rapamycin in patients with Alzheimer’s disease is long overdue.
Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys
American Association for the Advancement of Science (AAAS) - Tập 9 Số 412 - 2017
Yumei Xiong, Kenneth W. Walker, Xiaoshan Min, Clarence Hale, Thanhvien Tran, Renée Komorowski, Jerry Yang, Jasmine Davda, Noi Nuanmanee, Dao Kemp, Xiaozhen Wang, Hantao Liu, Silke Miller, Ki Jeong Lee, Zhulun Wang, Murielle M. Véniant
Engineered long-acting GDF15-Fc fusion molecules reduce food intake and body weight and improve metabolic profiles in animal models of obesity.
Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
American Association for the Advancement of Science (AAAS) - Tập 6 Số 224 - 2014
Marco L. Davila, Isabelle Rivière, Xiuyan Wang, Shirley Bartido, Jae H. Park, Kevin J. Curran, Stephen S. Chung, Jolanta Stefanski, Oriana Bórquez-Ojeda, Malgorzata Olszewska, Jinrong Qu, Teresa Wasielewska, Qing He, Mitsú J. Fink, Himaly Shinglot, Maher Youssif, Mark Satter, Yongzeng Wang, James Hosey, Hilda Quintanilla, Elizabeth Halton, Yvette Bernal, Diana Bouhassira, Maria E. Arcila, Mithat Gönen, Gail J. Roboz, P. Maslak, Dan Douer, Mark A. Schroeder, Sergio Giralt, Michel Sadelain, Renier J. Brentjens
CD19 CAR T cell therapy induces complete remissions in 88% of 16 adult patients with relapsed or refractory acute lymphoblastic leukemia.
Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells
American Association for the Advancement of Science (AAAS) - Tập 4 Số 132 - 2012
John Scholler, Troy Brady, Gwendolyn Binder-Scholl, Wei‐Ting Hwang, Gabriela Plesa, Kristen Hege, Ashley N. Vogel, Michael Kalos, James L. Riley, Steven G. Deeks, Ronald T. Mitsuyasu, Wendy B. Bernstein, Naomi Aronson, Bruce L. Levine, Frederic D. Bushman, Carl H. June
Adoptively transferred chimeric antigen receptor T cells have stable stem cell–like persistence for at least a decade and more than 500 years of patient safety.
Identification of a Titin-Derived HLA-A1–Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3–Directed T Cells
American Association for the Advancement of Science (AAAS) - Tập 5 Số 197 - 2013
Brian Cameron, Andrew B. Gerry, Joseph Dukes, Jane Harper, Vivekanandan Kannan, Frayne Bianchi, Francis Grand, Joanna E. Brewer, Minnal Gupta, Gabriela Plesa, Giovanna Bossi, Annelise Vuidepot, Alex S. Powlesland, Alison Legg, Katherine J. Adams, Alan Bennett, Nicholas J. Pumphrey, Daniel Williams, Gwendolyn Binder-Scholl, Irina Kulikovskaya, Bruce L. Levine, James L. Riley, Angel Varela‐Rohena, Edward A. Stadtmauer, Aaron P. Rapoport, Gerald P. Linette, Carl H. June, Namir J. Hassan, Michael Kalos, Bent K. Jakobsen
T cells engineered to express affinity-enhanced TCRs directed to a MAGE A3 peptide cross-react with a similar, but unrelated, self-peptide.
Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients
American Association for the Advancement of Science (AAAS) - Tập 7 Số 285 - 2015
R. J. Morrison, Scott J. Hollister, Matthew Niedner, Maryam Ghadimi Mahani, Albert H. Park, Deepak Mehta, Richard G. Ohye, Glenn E. Green
Patient-specific, image-based design coupled with 3D biomaterial printing produced personalized implants for treatment of collapsed airways in patients with tracheobronchomalacia.
Testing the Right Target and Right Drug at the Right Stage
American Association for the Advancement of Science (AAAS) - Tập 3 Số 111 - 2011
Reisa A. Sperling, Clifford R. Jack, Paul M. Thompson
Drugs aimed at the initial stages of the Alzheimer’s disease pathology should be tested a decade before the onset of dementia.
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